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Drug resistance traits are often associated with life\u2010history costs in the absence of treatment. Schistosomiasis control programmes rely on mass drug administration to reduce human morbidity and mortality. Although hotspots of reduced drug efficacy have been reported, resistance is not widespread. Using Bayesian state\u2010space models (<jats:styled-content style=\"fixed-case\">SSM<\/jats:styled-content>s) fitted to data from an<jats:italic>in vivo<\/jats:italic>laboratory system, we tested the hypothesis that the spread of resistant<jats:italic>Schistosoma mansoni<\/jats:italic>may be limited by life\u2010history costs not present in susceptible counterparts.<jats:italic>S. mansoni<\/jats:italic>parasites from a praziquantel\u2010susceptible (S), a praziquantel\u2010resistant (R) or a mixed line of originally resistant and susceptible parasites (<jats:styled-content style=\"fixed-case\">RS<\/jats:styled-content>) were exposed to a range of praziquantel doses. Parasite numbers at each life stage were quantified in their molluscan intermediate and murine definitive hosts across four generations, and<jats:styled-content style=\"fixed-case\">SSM<\/jats:styled-content>s were used to estimate key life\u2010history parameters for each experimental group over time. Model outputs illustrated that parasite adult survival and fecundity in the murine host decreased across all lines, including R, with increasing drug pressure. Trade\u2010offs between adult survival and fecundity were observed in all untreated lines, and these remained strong in S with praziquantel pressure. In contrast, trade\u2010offs between adult survival and fecundity were lost under praziquantel pressure in R. As expected, parasite life\u2010history traits within the molluscan host were complex, but trade\u2010offs were demonstrated between parasite establishment and cercarial output. The observed trade\u2010offs between generations within hosts, which were modified by praziquantel treatment in the R line, could limit the spread of R parasites under praziquantel pressure. Whilst such complex life\u2010history costs may be difficult to detect using standard empirical methods, we demonstrate that<jats:styled-content style=\"fixed-case\">SSM<\/jats:styled-content>s provide robust estimates of life\u2010history parameters, aiding our understanding of costs and trade\u2010offs of resistant parasites within this system and beyond.<\/jats:p>","DOI":"10.1111\/eva.12558","type":"journal-article","created":{"date-parts":[[2017,9,25]],"date-time":"2017-09-25T15:15:53Z","timestamp":1506352553000},"page":"488-500","source":"Crossref","is-referenced-by-count":23,"title":["The effects of subcurative praziquantel treatment on life\u2010history traits and trade\u2010offs in drug\u2010resistant<i>Schistosoma mansoni<\/i>"],"prefix":"10.1111","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5975-6505","authenticated-orcid":false,"given":"Mafalda","family":"Viana","sequence":"first","affiliation":[{"name":"Institute for Biodiversity, Animal Health and Comparative Medicine University of Glasgow Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8824-7424","authenticated-orcid":false,"given":"Christina L.","family":"Faust","sequence":"additional","affiliation":[{"name":"Institute for Biodiversity, Animal Health and Comparative Medicine University of Glasgow Glasgow UK"},{"name":"Wellcome Centre for Molecular Parasitology University of Glasgow Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel T.","family":"Haydon","sequence":"additional","affiliation":[{"name":"Institute for Biodiversity, Animal Health and Comparative Medicine University of Glasgow Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne P.","family":"Webster","sequence":"additional","affiliation":[{"name":"London Centre for Neglected Tropical Disease Research Department of Infectious Disease Epidemiology School of Public Health Imperial College London London UK"},{"name":"Centre for Endemic, Emerging and Exotic Diseases The Royal Veterinary College University of London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1048-6318","authenticated-orcid":false,"given":"Poppy H. 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