{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T02:44:19Z","timestamp":1792291459798,"version":"4.4.0"},"reference-count":39,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,1,10]],"date-time":"2018-01-10T00:00:00Z","timestamp":1515542400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"publisher","award":["U01\/DD001033"],"award-info":[{"award-number":["U01\/DD001033"]}],"id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evolutionary Applications"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We argue that reproductive suppression has clinical implications beyond its contribution to the burden of spontaneous abortion. We theorize that the incidence of births before the 28th week of gestation, which contribute disproportionately to infant morbidity and mortality, varies over time in part due to reproductive suppression in the form of selection in utero. We further theorize that the prevalence of structural birth defects among survivors to birth from conception cohorts gauges selection in utero. We based these theories on literature positing that natural selection conserved mechanisms that spontaneously abort \u201crisky\u201d pregnancies including those otherwise likely to yield infants with structural birth defects or small\u2010for\u2010gestational age males. We test our theory using high\u2010quality birth defect surveillance data. We identify 479,885 male infants exposed to strong selection defined as membership in conception cohorts ranked in the lowest quartile of odds of a birth defect among live\u2010born females. We estimate the risk of periviable birth among these infants as a function of selective pressure as well as of mother's race\/ethnicity and age. We find that male infants from exposed conception cohorts exhibited 10% lower odds of periviable birth than males from other conception cohorts. Our findings support the argument that selection in utero has implications beyond its contribution to the burden of spontaneous abortion.<\/jats:p>","DOI":"10.1111\/eva.12585","type":"journal-article","created":{"date-parts":[[2017,12,6]],"date-time":"2017-12-06T16:38:38Z","timestamp":1512578318000},"page":"762-767","source":"Crossref","is-referenced-by-count":4,"title":["Reproductive suppression, birth defects, and periviable birth"],"prefix":"10.1111","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7240-415X","authenticated-orcid":false,"given":"Ralph","family":"Catalano","sequence":"first","affiliation":[{"name":"School of Public Health University of California  Berkeley CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6927-964X","authenticated-orcid":false,"given":"Tim A.","family":"Bruckner","sequence":"additional","affiliation":[{"name":"Program in Public Health University of California  Irvine CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5909-5441","authenticated-orcid":false,"given":"Deborah","family":"Karasek","sequence":"additional","affiliation":[{"name":"School of Public Health University of California  Berkeley CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4613-7523","authenticated-orcid":false,"given":"Wei","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Neonatology Stanford University School of Medicine  Stanford CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7438-4914","authenticated-orcid":false,"given":"Gary M.","family":"Shaw","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Neonatology Stanford University School of Medicine  Stanford CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,1,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2014.3351"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2015-4434"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/evan.21369"},{"key":"e_1_2_7_5_1","volume-title":"Time series analysis, control, and forecasting","author":"Box G. 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