{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T06:30:25Z","timestamp":1761892225735,"version":"build-2065373602"},"reference-count":16,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,2,15]],"date-time":"2018-02-15T00:00:00Z","timestamp":1518652800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Center for Equine Health"},{"name":"State of California pari-mutuel fund"}],"content-domain":{"domain":["beva.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Equine Veterinary Education"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Silicate associated osteoporosis (\n                    <jats:styled-content style=\"fixed-case\">SAO<\/jats:styled-content>\n                    ) was diagnosed post\u2010mortem in an adult horse with the shortest documented exposure to cytotoxic silicates of 2\u00a0years. The horse was evaluated for a 6\u2010month history of progressive back tenderness and acute onset of lameness. The horse had a marked (4\/5) (American Association of Equine Practitioners scale) left forelimb lameness, moderate (2\/5) hindlimb ataxia and weakness, and cervical pain upon palpation. Physical examination did not reveal clinical skeletal deformities or respiratory compromise. Radiographs revealed widespread, discrete, sharply delineated, osteolytic lesions in the skull, vertebral column, ribs, scapulae and middle phalanx (P2) of the left forelimb and a diffuse bronchointerstitial lung pattern. The presumptive clinical diagnosis was widespread, metastatic osteolytic neoplasia. Due to the poor quality of life and grave prognosis, the horse was humanely euthanised. Post\u2010mortem examination revealed pulmonary silicosis in the lungs and hilar lymph nodes and osteolytic lesions with numerous, large osteoclasts and disorganised bone remodelling both consistent with\n                    <jats:styled-content style=\"fixed-case\">SAO<\/jats:styled-content>\n                    .\n                    <jats:styled-content style=\"fixed-case\">SAO<\/jats:styled-content>\n                    should be included as a differential diagnosis for horses with widespread, multifocal, discrete osteolysis and history of exposure to endemic regions with possible cytotoxic silicate inhalation. Exposure time of 2\u00a0years is potentially sufficient to develop\n                    <jats:styled-content style=\"fixed-case\">SAO<\/jats:styled-content>\n                    .\n                  <\/jats:p>","DOI":"10.1111\/eve.12899","type":"journal-article","created":{"date-parts":[[2018,2,15]],"date-time":"2018-02-15T00:24:17Z","timestamp":1518654257000},"page":"517-522","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Multifocal discrete osteolysis in a horse with silicate associated osteoporosis"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8433-3042","authenticated-orcid":false,"given":"R.","family":"Zavodovskaya","sequence":"first","affiliation":[{"name":"Department of Anatomy, Physiology and Cell Biology School of Veterinary Medicine University of California\u2010Davis Davis California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Eckert","sequence":"additional","affiliation":[{"name":"One on One Integrative Equine LLC Modesto California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B. G.","family":"Murphy","sequence":"additional","affiliation":[{"name":"Department Pathology, Microbiology and Immunology School of Veterinary Medicine University of California\u2010Davis Davis California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. M.","family":"Stover","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Physiology and Cell Biology School of Veterinary Medicine University of California\u2010Davis Davis California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Kol","sequence":"additional","affiliation":[{"name":"Department Pathology, Microbiology and Immunology School of Veterinary Medicine University of California\u2010Davis Davis California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Diab","sequence":"additional","affiliation":[{"name":"California Animal Health and Food Safety Laboratory School of Veterinary Medicine University of California\u2010Davis Davis California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,2,15]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.232.11.1694"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300985810385151"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.242.1.76"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2015.04.027"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcv012"},{"key":"e_1_2_9_7_1","unstructured":"Durham M.andArmstrong C.M.(2006)Fractures and bone deformities in 18 horses with silicosis. 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