{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T19:40:38Z","timestamp":1784749238885,"version":"3.55.0"},"reference-count":58,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,5,15]],"date-time":"2013-05-15T00:00:00Z","timestamp":1368576000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["beva.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Equine Veterinary Journal"],"published-print":{"date-parts":[[2014,1]]},"abstract":"Summary<\/jats:title>\n \n Reasons for performing study<\/jats:title>\n Cyathostomins comprise 50 helminth species, considered the most problematic equine endoparasites. Three classes of anthelmintic are currently licensed for their control, namely the benzimidazoles (fenbendazole), tetrahydropyrimidines (pyrantel) and macrocyclic lactones (ivermectin and moxidectin). Anthelmintic resistance in cyathostomins is common. With no new classes expected in the near future, it is essential to determine the efficacy of the available anthelmintics to inform future control programmes.<\/jats:p>\n <\/jats:sec>\n \n Objectives<\/jats:title>\n \n To determine the efficacy of all 3 anthelmintic classes against strongyles in equids on livery yards in east and central\n S<\/jats:styled-content>\n cotland.\n <\/jats:p>\n <\/jats:sec>\n \n Study design<\/jats:title>\n Anthelmintic efficacy testing using the faecal egg count reduction test (FECRT).<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n FECRT<\/jats:styled-content>\n s were performed on equids with initial strongyle faecal egg counts (\n FEC<\/jats:styled-content>\n s) of \u226550 eggs per gram. Efficacy was determined by comparing pretreatment (Day 0) and 14 days post treatment (Day 14)\n FEC<\/jats:styled-content>\n s. The following chemicals were tested: fenbendazole, pyrantel, ivermectin and moxidectin. Group arithmetic mean\n FECR<\/jats:styled-content>\n of >90% for fenbendazole and pyrantel, and >95% for ivermectin and moxidectin, represented efficacy, whereas lower mean\n FECR<\/jats:styled-content>\n indicated potential resistance.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n A total of 447\n FECRT<\/jats:styled-content>\n s were performed on 15 yards, as follows (the numbers in parentheses represent the number of yards each anthelmintic was tested on): 55 equids (7 yards) fenbendazole, 111 (8 yards) pyrantel, 163 (13 yards) ivermectin and 118 (10 yards) moxidectin. Fenbendazole resistance was documented on all yards (range of mean\n FECR<\/jats:styled-content>\n , 15.8\u201383.4%), whereas pyrantel (90.4\u201399.6%), ivermectin (99.5\u2013100%) and moxidectin (99.4\u2013100%) treatment had acceptable efficacy.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Reduced efficacy of fenbendazole was widespread, whereas >90% efficacy was found after pyrantel, and >95% efficacy after ivermectin and moxidectin. Overall, efficacies were higher than reported previously in\n E<\/jats:styled-content>\n urope and the\n USA<\/jats:styled-content>\n , potentially reflecting differences in management and anthelmintic use on the yards surveyed.\n <\/jats:p>\n <\/jats:sec>\n \n Potential relevance<\/jats:title>\n \n The use of fenbendazole for strongyle control in\n S<\/jats:styled-content>\n cotland should be questioned. Targeted use of pyrantel should be encouraged to reduce reliance on macrocyclic lactones. Further work to correlate management practices with the presence of anthelmintic resistance is warranted.\n <\/jats:p>\n \n \n The\n S<\/jats:styled-content>\n ummary is available in\n C<\/jats:styled-content>\n hinese \u2013 see\n S<\/jats:styled-content>\n upporting information.\n <\/jats:bold>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/evj.12079","type":"journal-article","created":{"date-parts":[[2013,3,13]],"date-time":"2013-03-13T04:01:56Z","timestamp":1363147316000},"page":"17-24","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["An investigation of anthelmintic efficacy against strongyles on equine yards in\n S<\/scp>\n cotland"],"prefix":"10.1111","volume":"46","author":[{"given":"C. H.","family":"Stratford","sequence":"first","affiliation":[{"name":"Royal (Dick) School of Veterinary Studies and Roslin Institute University of Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. E.","family":"Lester","sequence":"additional","affiliation":[{"name":"Disease Control Moredun Research Institute Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. J.","family":"Pickles","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine and Epidemiology University of California, Davis USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. C.","family":"McGorum","sequence":"additional","affiliation":[{"name":"Royal (Dick) School of Veterinary Studies and Roslin Institute University of Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. B.","family":"Matthews","sequence":"additional","affiliation":[{"name":"Disease Control Moredun Research Institute Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,5,15]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-4017(99)00092-8"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0749-0739(17)30092-5"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3292.2010.00084.x"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-4017(99)00091-6"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11259-006-3402-5"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2004.08.001"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2001.218.1957"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2006.03.019"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.158.17.596"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prevetmed.2007.07.006"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/01652176.1993.9694363"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2006.09.036"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-008-0959-7"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.162.12.384"},{"key":"e_1_2_11_16_1","unstructured":"Trawford A.F. 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