{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T23:04:59Z","timestamp":1770505499015,"version":"3.49.0"},"reference-count":13,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,7,4]],"date-time":"2013-07-04T00:00:00Z","timestamp":1372896000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["beva.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Equine Veterinary Journal"],"published-print":{"date-parts":[[2014,3]]},"abstract":"Summary<\/jats:title>\n \n Reasons for performing study<\/jats:title>\n \n Plasma fructosamine concentration ([fructosamine]) is believed to reflect medium term, average blood glucose concentration and in a previous study was higher in horses with active laminitis than in normal horses. Pituitary\n pars intermedia<\/jats:italic>\n dysfunction (\n PPID<\/jats:styled-content>\n ) is associated with hyperglycaemia and laminitis.\n <\/jats:p>\n <\/jats:sec>\n \n Objectives<\/jats:title>\n \n To test the hypotheses that: [fructosamine] is higher in\n PPID<\/jats:styled-content>\n cases than normal animals; furthermore, that within cases of\n PPID<\/jats:styled-content>\n [fructosamine] is higher in those with active laminitis than nonlaminitic cases and in cases that have been affected by active laminitis in the preceding year than those that have not.\n <\/jats:p>\n <\/jats:sec>\n \n Study design<\/jats:title>\n Observational, case\u2013control\/cross\u2010sectional study.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n [Fructosamine] was measured in cases of\n PPID<\/jats:styled-content>\n (n = 46) and normal animals (n = 139). A normal range was calculated; values were compared between the 2 groups and within the\n PPID<\/jats:styled-content>\n group, between cases with and without active laminitis and between cases that had and had not been affected by active laminitis in the preceding year.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n In normal animals mean [fructosamine] was 248.7\u2009\u03bcmol\/l; the normal range (mean \u00b1 2\u2009s.d.) was 195.5\u2013301.9\u2009\u03bcmol\/l. Plasma [fructosamine] was not higher in\n PPID<\/jats:styled-content>\n cases than in normal animals. In\n PPID<\/jats:styled-content>\n cases, [fructosamine] was significantly (P = 0.006) higher in cases with active laminitis (mean \u00b1 s.d. 261.2 \u00b1 39.2\u2009\u03bcmol\/l) compared with those without active laminitis (234.5 \u00b1 32.9\u2009\u03bcmol\/), but [fructosamine] was not higher in cases that had been affected by active laminitis in the preceding year than those that had not.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n In horses affected by\n PPID<\/jats:styled-content>\n , [fructosamine] is higher in cases with active laminitis than in cases without active laminitis.\n <\/jats:p>\n <\/jats:sec>\n \n Potential relevance<\/jats:title>\n \n Clinical use of [fructosamine] is limited due to overlap with the normal range. Further studies into glucose and protein metabolism in cases of\n PPID<\/jats:styled-content>\n are warranted.\n <\/jats:p>\n \n \n The\n S<\/jats:styled-content>\n ummary is available in\n C<\/jats:styled-content>\n hinese \u2013 see\n S<\/jats:styled-content>\n upporting information.\n <\/jats:bold>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/evj.12090","type":"journal-article","created":{"date-parts":[[2013,4,15]],"date-time":"2013-04-15T21:54:42Z","timestamp":1366062882000},"page":"249-251","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Plasma fructosamine concentrations in horses with pituitary\n pars intermedia<\/i>\n dysfunction with and without laminitis"],"prefix":"10.1111","volume":"46","author":[{"given":"E. J.","family":"Knowles","sequence":"first","affiliation":[{"name":"Bell Equine Veterinary Clinic Maidstone UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. J.","family":"Menzies\u2010Gow","sequence":"additional","affiliation":[{"name":"The Royal Veterinary College North Mymms UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. S.","family":"Mair","sequence":"additional","affiliation":[{"name":"Bell Equine Veterinary Clinic Maidstone UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,7,4]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.1993.tb03183.x"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.27.7.1761"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3306.2011.00419.x"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cveq.2010.12.007"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.2746\/0425164044877215"},{"key":"e_1_2_11_7_1","first-page":"40","article-title":") Hematologic and biochemical parameters in three high performance horse breeds from Southern Brazil","volume":"11","author":"Lacerda L.","year":"2006","journal-title":"Arch. Vet. Sci."},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0034-5288(97)90002-3"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3306.2011.00444.x"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.2746\/042516402776250333"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(83)90078-5"},{"key":"e_1_2_11_12_1","volume-title":"Studies on the Histopathology of Acute Laminitis","author":"Obel N.","year":"1948"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3292.1992.tb01595.x"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0739-7240(94)00006-M"}],"container-title":["Equine Veterinary Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fevj.12090","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/beva.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/evj.12090","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T08:31:25Z","timestamp":1762072285000},"score":1,"resource":{"primary":{"URL":"https:\/\/beva.onlinelibrary.wiley.com\/doi\/10.1111\/evj.12090"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7,4]]},"references-count":13,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["10.1111\/evj.12090"],"URL":"https:\/\/doi.org\/10.1111\/evj.12090","archive":["Portico"],"relation":{},"ISSN":["0425-1644","2042-3306"],"issn-type":[{"value":"0425-1644","type":"print"},{"value":"2042-3306","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,7,4]]},"assertion":[{"value":"2012-08-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-04-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-07-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}