{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T06:19:16Z","timestamp":1776925156552,"version":"3.51.2"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,8,30]],"date-time":"2013-08-30T00:00:00Z","timestamp":1377820800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["beva.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Equine Veterinary Journal"],"published-print":{"date-parts":[[2014,3]]},"abstract":"Summary<\/jats:title>\n \n Reasons for performing study<\/jats:title>\n \n H<\/jats:styled-content>\n ereditary equine regional dermal asthenia (\n HERDA<\/jats:styled-content>\n ) is an autosomal recessive disorder of\n Q<\/jats:styled-content>\n uarter\n H<\/jats:styled-content>\n orses characterised by skin fragility. Horses with\n HERDA<\/jats:styled-content>\n have a missense mutation in peptidyl\u2010prolyl\n cis\u2010trans<\/jats:italic>\n isomerase\u2009\n B<\/jats:styled-content>\n (\n \n PPIB<\/jats:styled-content>\n <\/jats:italic>\n ), which encodes cyclophilin\u2009\n B<\/jats:styled-content>\n and alters folding and post translational modifications of fibrillar collagen.\n <\/jats:p>\n <\/jats:sec>\n \n Objectives<\/jats:title>\n \n The study aimed to test the hypothesis that tendons, ligaments and great vessels, which, like skin, are rich in fibrillar collagen, will also have abnormal biomechanical properties in horses with\n HERDA<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Study design<\/jats:title>\n \n Ex vivo<\/jats:italic>\n biomechanical study comparing horses with and without a diagnosis of\n HERDA<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Forelimb suspensory ligament, superficial and deep digital flexor tendons; withers, forelimb and abdominal skin; the main pulmonary artery and the aortic arch were harvested from 6 horses with\n HERDA<\/jats:styled-content>\n and 6 control horses without the\n HERDA<\/jats:styled-content>\n allele. Tissues were distracted to failure. Tensile strength (\n TS<\/jats:styled-content>\n ), elastic modulus (\n EM<\/jats:styled-content>\n ) and energy to failure (\n ETF<\/jats:styled-content>\n ) were compared.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Horses with\n HERDA<\/jats:styled-content>\n had significantly lower\n TS<\/jats:styled-content>\n and\n EM<\/jats:styled-content>\n in tendinoligamentous tissues and great vessels, respectively. The\n TS<\/jats:styled-content>\n ,\n EM<\/jats:styled-content>\n and\n ETF<\/jats:styled-content>\n were significantly lower in skin from horses with\n HERDA<\/jats:styled-content>\n . Differences in\n TS<\/jats:styled-content>\n and\n ETF<\/jats:styled-content>\n were more extreme at the withers than at the forelimb or abdomen.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Tendinoligamentous tissue, great vessels and skin are significantly weaker in horses with\n HERDA<\/jats:styled-content>\n than in horses lacking the\n \n PPIB<\/jats:styled-content>\n <\/jats:italic>\n mutation, substantiating that diverse tissues with high fibrillar collagen content are abnormal in\n HERDA<\/jats:styled-content>\n and that the\n HERDA<\/jats:styled-content>\n phenotype is not limited to the integument.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/evj.12110","type":"journal-article","created":{"date-parts":[[2013,6,6]],"date-time":"2013-06-06T05:47:03Z","timestamp":1370497623000},"page":"216-222","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Tensile properties in collagen\u2010rich tissues of\n Q<\/scp>\n uarter\n H<\/scp>\n orses with hereditary equine regional dermal asthenia (\n HERDA<\/scp>\n )"],"prefix":"10.1111","volume":"46","author":[{"given":"J. E.","family":"Bowser","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences College of Veterinary Medicine Mississippi State University USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. H.","family":"Elder","sequence":"additional","affiliation":[{"name":"Department of Agricultural & Biological Engineering Mississippi State University USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Pasquali","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Utah School of Medicine and ARUP Laboratories Inc. USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. G.","family":"Grady","sequence":"additional","affiliation":[{"name":"Dilworth Small Animal Hospital Tupelo Mississippi USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. M.","family":"Rashmir\u2010Raven","sequence":"additional","affiliation":[{"name":"Department of Large Animal Clinical Sciences College of Veterinary Medicine Michigan State University USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Wills","sequence":"additional","affiliation":[{"name":"Department of Pathobiology and Population Medicine College of Veterinary Medicine Mississippi State University USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. E.","family":"Swiderski","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences College of Veterinary Medicine Mississippi State University USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,8,30]]},"reference":[{"key":"e_1_2_11_2_1","first-page":"350","article-title":"Hyperelastosis cutis in two horses","volume":"2","author":"Lerner D.J.","year":"1978","journal-title":"J. Am. Anim. Hosp. 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