{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T22:28:44Z","timestamp":1778279324679,"version":"3.51.4"},"reference-count":34,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,2,18]],"date-time":"2014-02-18T00:00:00Z","timestamp":1392681600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Faculty of Veterinary Science Research Fund"},{"name":"Department of Companion Animal Clinical Studies, University of Pretoria"},{"name":"Abe Bailey Trust"}],"content-domain":{"domain":["beva.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Equine Veterinary Journal"],"published-print":{"date-parts":[[2014,11]]},"abstract":"Summary<\/jats:title>\n \n Reasons for performing study<\/jats:title>\n \n Clinical indications for hydroxyethyl starches (\n HES<\/jats:styled-content>\n ) in horses include rapid plasma volume expansion and oncotic support during periods of hypoproteinaemia. Side effects such as coagulopathies associated with\n HES<\/jats:styled-content>\n administration pose limitations to their use in veterinary medicine. In man, tetrastarch (130\/0.4) has demonstrated less profound effects on coagulation compared with first\u2010 and second\u2010generation\n HES<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Objectives<\/jats:title>\n To evaluate the haemostatic and oncotic effects of tetrastarch (130\/0.4) administered at 10, 20 and 40\u2009ml\/kg bwt in healthy horses.<\/jats:p>\n <\/jats:sec>\n \n Study design<\/jats:title>\n Randomised crossover experiment.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Tetrastarch (130\/0.4) was administered to 6 healthy pony mares at 10, 20 and 40\u2009ml\/kg bwt with a 2\u2010week washout period. Packed cell volume, plasma total solids, colloid osmotic pressure (\n COP<\/jats:styled-content>\n ), platelet count and thromboelastography (\n TEG<\/jats:styled-content>\n ) were measured at baseline, immediately after infusion (0\u2009h), and 1, 6, 12, 24, 48 and 96\u2009h after tetrastarch infusion.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n All\n TEG<\/jats:styled-content>\n variables remained within normal reference ranges in all 3 treatment groups. Administration of tetrastarch at 40\u2009ml\/kg bwt resulted in a prolonged\n K<\/jats:styled-content>\n \u2010time (P = 0.049) at 6\u2009h post infusion, and decreased maximum amplitude at 0 (P<0.001), 1 (P = 0.022), 6 (P = 0.006), 24 (P<0.001) and 48\u2009h (P = 0.013) post infusion compared with baseline. Administration of tetrastarch increased mean\n COP<\/jats:styled-content>\n values above baseline in all 3 treatment groups, persisting to 24, 6 and 48\u2009h for the 10, 20 and 40\u2009ml\/kg bwt doses, respectively.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Although still within established reference ranges, compared with lower dosages, the administration of 40\u2009ml\/kg bwt tetrastarch (130\/0.4) is more likely to induce changes in coagulation as measured by\n TEG<\/jats:styled-content>\n . Tetrastarch increased\n COP<\/jats:styled-content>\n at all dosages evaluated in healthy horses. Tetrastarch (130\/0.4) at 10 and 20\u2009ml\/kg bwt has potential as a synthetic colloid for resuscitation and provision of oncotic support in horses.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/evj.12223","type":"journal-article","created":{"date-parts":[[2013,12,24]],"date-time":"2013-12-24T04:20:41Z","timestamp":1387858841000},"page":"739-744","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Coagulation, oncotic and haemodilutional effects of a third\u2010generation hydroxyethyl starch (130\/0.4) solution in horses"],"prefix":"10.1111","volume":"46","author":[{"given":"A.","family":"Viljoen","sequence":"first","affiliation":[{"name":"Department of Companion Animal Clinical Studies Faculty of Veterinary Science University of Pretoria Onderstepoort South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. C.","family":"Page","sequence":"additional","affiliation":[{"name":"Department of Companion Animal Clinical Studies Faculty of Veterinary Science University of Pretoria Onderstepoort South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. T.","family":"Fosgate","sequence":"additional","affiliation":[{"name":"Department of Production Animal Studies Faculty of Veterinary Science University of Pretoria Onderstepoort South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8078-1748","authenticated-orcid":false,"given":"M. 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