{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T10:52:43Z","timestamp":1778583163007,"version":"3.51.4"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,5,19]],"date-time":"2014-05-19T00:00:00Z","timestamp":1400457600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100001250","name":"Morris Animal Foundation","doi-asserted-by":"publisher","award":["D09EQ-605"],"award-info":[{"award-number":["D09EQ-605"]}],"id":[{"id":"10.13039\/100001250","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Oregon State University Department of Biomedical Sciences (intramural grant)"}],"content-domain":{"domain":["beva.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Equine Veterinary Journal"],"published-print":{"date-parts":[[2015,3]]},"abstract":"Summary<\/jats:title>\n \n Reasons for performing study<\/jats:title>\n \n Exertional rhabdomyolysis (\n ER<\/jats:styled-content>\n ) is a reported syndrome in competing endurance horses; however, the prevalence and cause of\n ER<\/jats:styled-content>\n in this population have not been defined.\n <\/jats:p>\n <\/jats:sec>\n \n Objectives<\/jats:title>\n \n To determine the prevalence of\n ER<\/jats:styled-content>\n in a sample of endurance racing horses and investigate factors, including relevant genetic defects, contributing to the occurrence of rhabdomyolysis in this group.\n <\/jats:p>\n <\/jats:sec>\n \n Study design<\/jats:title>\n Prospective clinical study.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Riders of 101 horses participating in one of four 50\u2010mile (80.5\u2009km) distance races completed a comprehensive questionnaire regarding the medical history, management and performance of their horse. Serum creatine kinase activity (\n CK<\/jats:styled-content>\n ) was measured before and 4\u2009h after completion of exercise. Hair samples were analysed by\n PCR<\/jats:styled-content>\n for the\n R309H<\/jats:styled-content>\n mutation in the glycogen synthase gene (\n \n GYS<\/jats:styled-content>\n 1\n <\/jats:italic>\n ) responsible for\n type 1<\/jats:italic>\n polysaccharide storage myopathy (\n PSSM<\/jats:styled-content>\n ) and the\n C7360G<\/jats:styled-content>\n mutation in the ryanodine receptor 1 (\n \n RYR<\/jats:styled-content>\n 1\n <\/jats:italic>\n ) gene causing malignant hyperthermia (\n MH<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Samples were obtained from 68\n A<\/jats:styled-content>\n rabians, 20 half\u2010\n A<\/jats:styled-content>\n rabians and 13 horses of other breeds. Serum\n CK<\/jats:styled-content>\n was above the resting reference interval (145\u2013633 u\/l) in 38 horses after racing (median 883 u\/l, range 658\u20133739) but was compatible with values previously reported in apparently healthy endurance horses. Pathological\n ER<\/jats:styled-content>\n was suspected to occur in 4 horses with serum\n CK<\/jats:styled-content>\n activities exceeding 10,000 u\/l 4\u2009h after racing (median 84,825 u\/l; range 10,846\u2013381,790) including 3\n A<\/jats:styled-content>\n rabians and one half\u2010\n A<\/jats:styled-content>\n rabian horse.\n \n GYS<\/jats:styled-content>\n 1\n <\/jats:italic>\n and\n \n RYR<\/jats:styled-content>\n 1\n <\/jats:italic>\n mutations were not present in hair samples from any horses.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Exertional rhabdomyolysis occurred at a prevalence of 4.0% in a sample of horses participating in 50 mile distance events and all affected horses were\n A<\/jats:styled-content>\n rabian or half\u2010\n A<\/jats:styled-content>\n rabian. The cause of\n ER<\/jats:styled-content>\n in the endurance horse population remains unknown; however,\n ER<\/jats:styled-content>\n in competing\n A<\/jats:styled-content>\n rabian endurance horses is unlikely to be due to\n type 1<\/jats:italic>\n \u2005\n PSSM<\/jats:styled-content>\n or\n MH<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/evj.12255","type":"journal-article","created":{"date-parts":[[2014,3,3]],"date-time":"2014-03-03T03:54:44Z","timestamp":1393818884000},"page":"165-170","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Prevalence of exertional rhabdomyolysis in endurance horses in the\n P<\/scp>\n acific\n N<\/scp>\n orthwestern\n U<\/scp>\n nited\n S<\/scp>\n tates"],"prefix":"10.1111","volume":"47","author":[{"given":"M. S.","family":"Wilberger","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences College of Veterinary Medicine Oregon State University Corvallis Oregon USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. C.","family":"McKenzie","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences College of Veterinary Medicine Oregon State University Corvallis Oregon USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. E.","family":"Payton","sequence":"additional","affiliation":[{"name":"Department of Statistics College of Arts and Sciences Oklahoma State University Stillwater Oklahoma USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. D.","family":"Rigas","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences College of Veterinary Medicine Oregon State University Corvallis Oregon USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. J.","family":"Valberg","sequence":"additional","affiliation":[{"name":"Department of Veterinary Population Medicine College of Veterinary Medicine University of Minnesota St. Paul Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,5,19]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2000.216.554"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3306.1993.tb02893.x"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygeno.2008.01.011"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2005.227.762"},{"issue":"30","key":"e_1_2_11_6_1","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1111\/j.2042-3306.1999.tb05279.x","article-title":"Exertional rhabdomyolysis in quarter horses and Thoroughbreds: one syndrome, multiple aetiologies","volume":"31","author":"Valberg S.J.","year":"1999","journal-title":"Equine Vet. 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