{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T12:53:30Z","timestamp":1762606410926,"version":"build-2065373602"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,5,29]],"date-time":"2014-05-29T00:00:00Z","timestamp":1401321600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"North Carolina Horse Council"},{"name":"NIH T32 NIH\/NCSU Comparative Medicine and Translational Research Training Program (CMTRTP)","award":["T32OD011130"],"award-info":[{"award-number":["T32OD011130"]}]}],"content-domain":{"domain":["beva.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Equine Veterinary Journal"],"published-print":{"date-parts":[[2015,5]]},"abstract":"Summary<\/jats:title>\n \n Reasons for performing study<\/jats:title>\n There is an important need for objective parameters that accurately predict the outcome of horses with large colon volvulus.<\/jats:p>\n <\/jats:sec>\n \n Objectives<\/jats:title>\n To evaluate the predictive value of a series of histomorphometric parameters on short\u2010term outcome, as well as the impact of colonic resection on horses with large colon volvulus.<\/jats:p>\n <\/jats:sec>\n \n Study design<\/jats:title>\n Retrospective cohort study.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Adult horses admitted to the\n E<\/jats:styled-content>\n quine and\n F<\/jats:styled-content>\n arm\n A<\/jats:styled-content>\n nimal\n V<\/jats:styled-content>\n eterinary\n C<\/jats:styled-content>\n enter at\n N<\/jats:styled-content>\n orth\n C<\/jats:styled-content>\n arolina\n S<\/jats:styled-content>\n tate\n U<\/jats:styled-content>\n niversity,\n P<\/jats:styled-content>\n eterson and\n S<\/jats:styled-content>\n mith and\n C<\/jats:styled-content>\n hino\n V<\/jats:styled-content>\n alley\n E<\/jats:styled-content>\n quine\n H<\/jats:styled-content>\n ospitals between 2006 and 2013 that underwent an exploratory coeliotomy, diagnosed with large colon volvulus of \u2265360\u2009degrees, where a pelvic flexure biopsy was obtained, and that recovered from general anaesthesia, were selected for inclusion in the study. Logistic regression was used to determine associations between signalment, histomorphometric measurements of interstitium\u2010to\u2010crypt ratio, degree of haemorrhage, percentage loss of luminal and glandular epithelium, as well as colonic resection with short\u2010term outcome (discharge from the hospital).\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Pelvic flexure biopsies from 47 horses with large colon volvulus were evaluated. Factors that were significantly associated with short\u2010term outcome on univariate logistic regression were Thoroughbred breed (P = 0.04), interstitium\u2010to\u2010crypt ratio >1 (P = 0.02) and haemorrhage score \u22653 (P = 0.005). Resection (P = 0.92) was not found to be associated significantly with short\u2010term outcome. No combined factors increased the likelihood of death in forward stepwise logistic regression modelling. A digitally quantified measurement of haemorrhage area strengthened the association of haemorrhage with nonsurvival in cases of large colon volvulus.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Histomorphometric measurements of interstitium\u2010to\u2010crypt ratio and degree of haemorrhage predict short\u2010term outcome in cases of large colon volvulus. Resection was not associated with short\u2010term outcome in horses selected for this study. Accurate quantification of mucosal haemorrhage at the time of surgery may improve veterinary surgeons\u2019 prognostic capabilities in horses with large colon volvulus.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/evj.12273","type":"journal-article","created":{"date-parts":[[2014,4,15]],"date-time":"2014-04-15T08:26:52Z","timestamp":1397550412000},"page":"279-284","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Operative factors associated with short\u2010term outcome in horses with large colon volvulus: 47 cases from 2006 to 2013"],"prefix":"10.1111","volume":"47","author":[{"given":"L. M.","family":"Gonzalez","sequence":"first","affiliation":[{"name":"College of Veterinary Medicine North Carolina State University Raleigh USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. A.","family":"Fogle","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine North Carolina State University Raleigh USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. T.","family":"Baker","sequence":"additional","affiliation":[{"name":"Woodford Equine Hospital Versailles Kentucky USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F. E.","family":"Hughes","sequence":"additional","affiliation":[{"name":"Peterson and Smith Equine Hospital Ocala Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. M.","family":"Law","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine North Carolina State University Raleigh USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. A.","family":"Motsinger\u2010Reif","sequence":"additional","affiliation":[{"name":"Statistics Department North Carolina State University Raleigh USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. T.","family":"Blikslager","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine North Carolina State University Raleigh USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,5,29]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.2746\/042516408X293529"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-950X.2008.00449.x"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0749-0739(17)30243-2"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-950X.2012.00994.x"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-950X.2012.01081.x"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-950X.2007.00305.x"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3306.2012.00620.x"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1053\/jvet.2000.17836"},{"key":"e_1_2_11_10_1","first-page":"254","article-title":"Large colon volvulus: surgical treatment of 204 horses (1986\u20131995)","volume":"42","author":"Embertson R.M.","year":"1996","journal-title":"Proc. Am. Ass. Equine Practnrs"},{"key":"e_1_2_11_11_1","first-page":"273","volume-title":"Current Techniques in Equine Surgery and Lameness","author":"Van Hoogmoed L.","year":"1998"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-950X.2006.00157.x"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.1986.47.12.2530"},{"key":"e_1_2_11_14_1","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.2460\/javma.1994.204.11.1786","article-title":"Surface oximetry for intraoperative assessment of colonic viability in horses","volume":"204","author":"Snyder J.R.","year":"1994","journal-title":"J. Am. Vet. Med. Ass."},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cveq.2003.12.004"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.1988.49.06.801"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031-3203(94)E0043-K"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3306.2000.tb05343.x"},{"key":"e_1_2_11_19_1","first-page":"E6","article-title":"Mechanisms of oxidative injury in equine disease","volume":"34","author":"Wong D.M.","year":"2012","journal-title":"Comp. Cont. Educ. Pract. Vet."},{"key":"e_1_2_11_20_1","first-page":"E5","article-title":"Intestinal ischemia\u2010reperfusion injury in horses: pathogenesis and therapeutics","volume":"34","author":"Wong D.M.","year":"2012","journal-title":"Comp. Cont. Educ. Pract. Vet."},{"key":"e_1_2_11_21_1","doi-asserted-by":"crossref","first-page":"757","DOI":"10.2460\/javma.1989.195.06.757","article-title":"Strangulating volvulus of the ascending colon in horses","volume":"195","author":"Snyder J.R.","year":"1989","journal-title":"J. Am. Vet. Med. Ass."},{"key":"e_1_2_11_22_1","doi-asserted-by":"crossref","first-page":"454","DOI":"10.2460\/javma.1992.201.03.454","article-title":"Resection and anastomosis for treatment of strangulating volvulus of the large colon of horses","volume":"201","author":"Rose P.L.","year":"1992","journal-title":"J. Am. Vet. Med. Ass."},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-950X.1990.tb01232.x"},{"key":"e_1_2_11_24_1","first-page":"87","volume-title":"Proceedings 9th International Equine Colic Research Symposium","author":"Southwood L.","year":"2008"}],"container-title":["Equine Veterinary Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fevj.12273","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/beva.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/evj.12273","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T11:06:31Z","timestamp":1762081591000},"score":1,"resource":{"primary":{"URL":"https:\/\/beva.onlinelibrary.wiley.com\/doi\/10.1111\/evj.12273"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5,29]]},"references-count":23,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,5]]}},"alternative-id":["10.1111\/evj.12273"],"URL":"https:\/\/doi.org\/10.1111\/evj.12273","archive":["Portico"],"relation":{},"ISSN":["0425-1644","2042-3306"],"issn-type":[{"type":"print","value":"0425-1644"},{"type":"electronic","value":"2042-3306"}],"subject":[],"published":{"date-parts":[[2014,5,29]]},"assertion":[{"value":"2013-08-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-04-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-05-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}