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There is also evidence that exercise\u2010induced pulmonary haemorrhage and infectious diseases of the respiratory tract in horses have a genetic component. The clinical expression of equine respiratory diseases with a genetic basis results from complex interactions between the environment and the genetic make\u2010up of each individual horse. The genetic effects are likely to be due to variations in several genes, i.e. they are polygenic. It is therefore unlikely that single gene tests will be diagnostically useful in these disorders. Genetic profiling panels, combining several genetic factors with an assessment of environmental risk factors, may have greater value, but much work is still needed to uncover diagnostically useful genetic markers or even causative variants for equine respiratory diseases. Nonetheless, chromosomal regions associated with guttural pouch tympany, recurrent laryngeal neuropathy and\n                    <jats:styled-content style=\"fixed-case\">RAO<\/jats:styled-content>\n                    have been identified. The association of\n                    <jats:styled-content style=\"fixed-case\">RAO<\/jats:styled-content>\n                    with other hypersensitivities and with resistance to intestinal parasites requires further study. This review aims to provide an overview of the available data and current thoughts on the genetics of equine airway diseases.\n                  <\/jats:p>","DOI":"10.1111\/evj.12289","type":"journal-article","created":{"date-parts":[[2014,4,28]],"date-time":"2014-04-28T07:22:48Z","timestamp":1398669768000},"page":"390-397","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Genetics of upper and lower airway diseases in the horse"],"prefix":"10.1111","volume":"47","author":[{"given":"V.","family":"Gerber","sequence":"first","affiliation":[{"name":"Swiss Institute of Equine Medicine (ISME) DKV Vetsuisse Faculty University of Berne and ALP\u2010Haras Avenches  Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Tessier","sequence":"additional","affiliation":[{"name":"ONIRIS Ecole Nationale V\u00e9t\u00e9rinaire Agro\u2010Alimentaire et de l'Alimentation Nantes\u2010Atlantique Equine Surgery  Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Marti","sequence":"additional","affiliation":[{"name":"Division of Clinical Immunology DCR\u2010VPH University of Berne  Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,5,26]]},"reference":[{"key":"e_1_2_25_2_1","first-page":"595","article-title":"Untersuchungen \u00fcber die Erblichkeit und das Wesen des Lungendampfes beim Pferd","volume":"31","author":"Schaeper W.","year":"1939","journal-title":"Tieraerztl. 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