{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T18:18:23Z","timestamp":1792433903543,"version":"4.5.0"},"reference-count":37,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,12,14]],"date-time":"2014-12-14T00:00:00Z","timestamp":1418515200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100001250","name":"Morris Animal Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001250","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["beva.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Equine Veterinary Journal"],"published-print":{"date-parts":[[2015,11]]},"abstract":"Summary<\/jats:title>\n \n Reasons for performing study<\/jats:title>\n \n Disruptions in the gastrointestinal microbiota may trigger development of\n post partum<\/jats:italic>\n colic.\n <\/jats:p>\n <\/jats:sec>\n \n Objectives<\/jats:title>\n \n To determine the effects of the periparturient period on the faecal microbiome and identify associations between the faecal microbiota and\n post partum<\/jats:italic>\n colic.\n <\/jats:p>\n <\/jats:sec>\n \n Study design<\/jats:title>\n Longitudinal case\u2013control study.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Pre\u2010<\/jats:italic>\n and\n post partum<\/jats:italic>\n faecal samples were collected from mares on 3 farms in central\n K<\/jats:styled-content>\n entucky. Next generation sequencing of the\n V4<\/jats:styled-content>\n region of the\n 16S rRNA<\/jats:styled-content>\n gene was performed on samples from 13 mares that developed colic, 13 mares that did not display colic and 5 nonpregnant controls.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n There were 4,523,727 sequences from 85 samples evaluated (mean \u00b1 s.d. 53,220 \u00b1 29,160, range 8442\u2013122,535). Twenty\u2010five phyla were identified, although only Firmicutes, Verrucomicrobia, Actinobacteria and Proteobacteria were present at a relative abundance of 1% or greater. The faecal microbiota of late\u2010term mares differed from nonpregnant mares, with differences in microbial community membership and structure but not the relative abundance of major phyla. There was limited impact of foaling and the\n post partum<\/jats:italic>\n period on the faecal microbiome. Faecal samples obtained from mares prior to episodes of colic had significantly higher relative abundance of Proteobacteria (8.2%, P = 0.0006) compared with samples from mares that did not display colic (3.7%). All samples with a relative abundance of Firmicutes of \u226450% preceded colic, as did 6\/7 (86%) samples with >4% Proteobacteria. Differences in microbiota membership and structure were also present between mares that developed large colon volvulus and matched controls that did not have colic. Sixty\u2010one indicator operational taxon units were identified for the control (vs. volvulus) samples, and these were dominated by Lachnospiraceae (n = 38) and Ruminococcaceae (n = 8).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Foaling had minimal effects on the mares' faecal microbiota. Numerous differences in the faecal microbiota preceded colic. Associations between Firmicutes (particularly Lachnospiraceae and Ruminococcaceae) and Proteobacteria and development of colic could lead to measures to predict and prevent colic.<\/jats:p>\n \n The Summary is available in Chinese \u2013 see Supporting information.<\/jats:bold>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/evj.12361","type":"journal-article","created":{"date-parts":[[2014,9,25]],"date-time":"2014-09-25T07:21:58Z","timestamp":1411629718000},"page":"641-649","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":141,"title":["Changes in the faecal microbiota of mares precede the development of\n post partum<\/i>\n colic"],"prefix":"10.1111","volume":"47","author":[{"given":"J. S.","family":"Weese","sequence":"first","affiliation":[{"name":"Department of Pathobiology Ontario Veterinary College University of Guelph Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. 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E.","family":"Wismer","sequence":"additional","affiliation":[{"name":"Rood and Riddle Equine Hospital Lexington Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,12,14]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1111\/j.1532-950X.1990.tb01232.x","article-title":"Vascular injury associated with naturally occurring strangulating obstructions of the equine large colon","volume":"19","author":"Snyder J.R.","year":"1990","journal-title":"Vet. Surg."},{"key":"e_1_2_11_3_1","doi-asserted-by":"crossref","first-page":"757","DOI":"10.2460\/javma.1989.195.06.757","article-title":"Strangulating volvulus of the ascending colon in horses","volume":"195","author":"Snyder J.R.","year":"1989","journal-title":"J. Am. Vet. Med. 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Notes"}],"container-title":["Equine Veterinary Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fevj.12361","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/beva.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/evj.12361","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T13:18:23Z","timestamp":1762089503000},"score":1,"resource":{"primary":{"URL":"https:\/\/beva.onlinelibrary.wiley.com\/doi\/10.1111\/evj.12361"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12,14]]},"references-count":37,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,11]]}},"alternative-id":["10.1111\/evj.12361"],"URL":"https:\/\/doi.org\/10.1111\/evj.12361","archive":["Portico"],"relation":{},"ISSN":["0425-1644","2042-3306"],"issn-type":[{"value":"0425-1644","type":"print"},{"value":"2042-3306","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12,14]]},"assertion":[{"value":"2014-04-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-09-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-12-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}