{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T15:47:03Z","timestamp":1770220023713,"version":"3.49.0"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,11,24]],"date-time":"2014-11-24T00:00:00Z","timestamp":1416787200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004385","name":"Universiteit Gent","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004385","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["beva.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Equine Veterinary Journal"],"published-print":{"date-parts":[[2016,1]]},"abstract":"Summary<\/jats:title>\n \n Reasons for performing study<\/jats:title>\n \n Shortening of atrial fibrillation cycle length (\n AFCL<\/jats:styled-content>\n ) is a marker of atrial electrical remodelling due to atrial fibrillation (\n AF<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Objectives<\/jats:title>\n \n To investigate the effect of administration of detomidine on\n AFCL<\/jats:styled-content>\n measured invasively from an intra\u2010atrial electrogram (\n \n AFCL\n EGM<\/jats:sub>\n <\/jats:styled-content>\n ) and noninvasively by tissue\n D<\/jats:styled-content>\n oppler imaging (\n \n AFCL\n TDI<\/jats:sub>\n <\/jats:styled-content>\n ). We hypothesised that detomidine would have no effect on\n AFCL<\/jats:styled-content>\n but would improve the ease of\n TDI<\/jats:styled-content>\n measurements and facilitate noninvasive\n AFCL<\/jats:styled-content>\n determination.\n <\/jats:p>\n <\/jats:sec>\n \n Study design<\/jats:title>\n Prospective clinical study.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Measurements were performed before and after i.v. administration of 7.5\u2009\u03bcg\/kg bwt detomidine in 33 episodes of\n AF<\/jats:styled-content>\n in 32 horses (582 \u00b1 64\u2009kg bwt, 10 \u00b1 3 years old) referred for electrical cardioversion. The\n \n AFCL\n EGM<\/jats:sub>\n <\/jats:styled-content>\n was measured from a right atrial intracardiac electrogram. The\n \n AFCL\n TDI<\/jats:sub>\n <\/jats:styled-content>\n was measured from atrial colour tissue velocity curves in 5 atrial wall regions. Mean\n \n AFCL\n EGM<\/jats:sub>\n <\/jats:styled-content>\n and\n \n AFCL\n TDI<\/jats:sub>\n <\/jats:styled-content>\n without and with sedation were compared using a repeated\u2010measures linear mixed model with\n B<\/jats:styled-content>\n onferroni correction for multiple comparisons and calculation of the\n B<\/jats:styled-content>\n land\u2013\n A<\/jats:styled-content>\n ltman mean bias and limits of agreement between\n \n AFCL\n EGM<\/jats:sub>\n <\/jats:styled-content>\n and\n \n AFCL\n TDI<\/jats:sub>\n <\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The mean\n AFCL<\/jats:styled-content>\n was significantly increased after sedation, but this increase was very small (mean difference +4\u2009ms). For\n \n AFCL\n TDI<\/jats:sub>\n <\/jats:styled-content>\n measurements, sedation significantly improved the quality of the atrial myocardial velocity curves and the number of\n AF<\/jats:styled-content>\n cycles that could be measured per cardiac cycle. The\n B<\/jats:styled-content>\n land\u2013\n A<\/jats:styled-content>\n ltman bias between\n \n AFCL\n EGM<\/jats:sub>\n <\/jats:styled-content>\n without sedation and\n \n AFCL\n TDI<\/jats:sub>\n <\/jats:styled-content>\n with sedation ranged from \u201018 to +15\u2009ms depending on wall region.\n B<\/jats:styled-content>\n land\u2013\n A<\/jats:styled-content>\n ltman limits of agreement were similar between\n \n AFCL\n EGM<\/jats:sub>\n <\/jats:styled-content>\n without sedation and\n \n AFCL\n TDI<\/jats:sub>\n <\/jats:styled-content>\n without and with sedation. Therefore, noninvasive\n \n AFCL\n TDI<\/jats:sub>\n <\/jats:styled-content>\n measurements with sedation can be used to estimate the atrial fibrillatory rate.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Sedation facilitates noninvasive\n AFCL<\/jats:styled-content>\n measurements but causes a slight increase in\n AFCL<\/jats:styled-content>\n . Noninvasive\n AFCL<\/jats:styled-content>\n measurements can be used as an indicator of atrial electrical remodelling, to study\n AF<\/jats:styled-content>\n pathophysiology and to investigate the effect of anti\u2010arrhythmic drugs.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/evj.12366","type":"journal-article","created":{"date-parts":[[2014,9,30]],"date-time":"2014-09-30T06:17:06Z","timestamp":1412057826000},"page":"21-26","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Influence of detomidine on atrial fibrillation cycle length measured by intracardiac electrogram recording and by colour tissue\n D<\/scp>\n oppler imaging in horses"],"prefix":"10.1111","volume":"48","author":[{"given":"A.","family":"Decloedt","sequence":"first","affiliation":[{"name":"Department of Large Animal Internal Medicine Faculty of Veterinary Medicine Ghent University Merelbeke Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"de Clercq","sequence":"additional","affiliation":[{"name":"Department of Large Animal Internal Medicine Faculty of Veterinary Medicine Ghent University Merelbeke Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"van der Vekens","sequence":"additional","affiliation":[{"name":"Department of Large Animal Internal Medicine Faculty of Veterinary Medicine Ghent University Merelbeke Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Verheyen","sequence":"additional","affiliation":[{"name":"Department of Large Animal Internal Medicine Faculty of Veterinary Medicine Ghent University Merelbeke Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Ven","sequence":"additional","affiliation":[{"name":"Department of Large Animal Internal Medicine Faculty of Veterinary Medicine Ghent University Merelbeke Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"van Loon","sequence":"additional","affiliation":[{"name":"Department of Large Animal Internal Medicine Faculty of Veterinary Medicine Ghent University Merelbeke Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,11,24]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00031.2009"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(02)00258-4"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.85.5.428"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.110.945279"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.12322"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/tvjl.2001.0668"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2008.0202.x"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.92.7.1954"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/hc3401.093156"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/evj.12108"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0007-1935(96)80118-7"},{"key":"e_1_2_11_13_1","first-page":"139","article-title":"Cardiovascular and pulmonary function studies of a new sedative\/analgetic (detomidine\/Domosedan) for use alone in horses or as a preanesthetic","volume":"82","author":"Short C.E.","year":"1986","journal-title":"Acta Vet. 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