{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T12:28:00Z","timestamp":1762086480650,"version":"build-2065373602"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,1,30]],"date-time":"2015-01-30T00:00:00Z","timestamp":1422576000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Swedish Norwegian Foundation for Equine research","award":["H0847237"],"award-info":[{"award-number":["H0847237"]}]},{"DOI":"10.13039\/501100009069","name":"Royal Swedish Academy of Agriculture and Forestry","doi-asserted-by":"crossref","award":["H10-0265-CFH"],"award-info":[{"award-number":["H10-0265-CFH"]}],"id":[{"id":"10.13039\/501100009069","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["beva.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Equine Veterinary Journal"],"published-print":{"date-parts":[[2016,1]]},"abstract":"Summary<\/jats:title>\n \n Reasons for performing study<\/jats:title>\n \n Validated noninvasive detection methods for early osteoarthritis (\n OA<\/jats:styled-content>\n ) are required for\n OA<\/jats:styled-content>\n prevention and early intervention treatment strategies.\n <\/jats:p>\n <\/jats:sec>\n \n Objectives<\/jats:title>\n \n To evaluate radiography and low\u2010field magnetic resonance imaging (\n MRI<\/jats:styled-content>\n ) for the detection of early stage\n OA<\/jats:styled-content>\n osteochondral lesions in equine centrodistal joints using microscopy as the reference standard.\n <\/jats:p>\n <\/jats:sec>\n \n Study design<\/jats:title>\n Prospective imaging of live horses and imaging and microscopy of cadaver tarsal joints.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Centrodistal (distal intertarsal) joints of 38 Icelandic research horses aged 27\u201329 months were radiographed. Horses were subjected to euthanasia approximately 2 months later and cadaver joints examined with low\u2010field\n MRI<\/jats:styled-content>\n . Osteochondral joint specimens were classified as negative or positive for\n OA<\/jats:styled-content>\n using light microscopy histology or scanning electron microscopy. Radiographs and\n MRIs<\/jats:styled-content>\n were evaluated for osteochondral lesions and results compared with microscopy.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Forty\u2010two joints were classified\n OA<\/jats:styled-content>\n positive with microscopy. Associations were detected between microscopic\n OA<\/jats:styled-content>\n and the radiography lesion categories; mineralisation front defect (P<0.0001), joint margin lesion (P<0.0001), central osteophyte (P = 0.03) and the low\u2010field\n MRI<\/jats:styled-content>\n lesion categories; mineralisation front defect (P = 0.01), joint margin lesion (P = 0.02) and articular cartilage lesion (P = 0.0003). The most frequent lesion category detected in microscopic\n OA<\/jats:styled-content>\n positive joints was the mineralisation front defect in radiographs (28\/42\n OA<\/jats:styled-content>\n positive joints, specificity 97%, sensitivity 67%). No significant differences were detected between the sensitivity and specificity of radiography and low\u2010field\n MRI<\/jats:styled-content>\n pooled lesion categories, but radiography was often superior when individual lesion categories were compared.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Early stage centrodistal joint\n OA<\/jats:styled-content>\n changes may be detected with radiography and low\u2010field\n MRI<\/jats:styled-content>\n . Detection of mineralisation front defects in radiographs may be a useful screening method for detection of early\n OA<\/jats:styled-content>\n in centrodistal joints of young Icelandic horses.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/evj.12370","type":"journal-article","created":{"date-parts":[[2014,10,7]],"date-time":"2014-10-07T05:52:14Z","timestamp":1412661134000},"page":"57-64","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Detection of early osteoarthritis in the centrodistal joints of\n I<\/scp>\n celandic horses: Evaluation of radiography and low\u2010field magnetic resonance imaging"],"prefix":"10.1111","volume":"48","author":[{"given":"C. J.","family":"Ley","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences Swedish University of Agricultural Sciences Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Bj\u00f6rnsd\u00f3ttir","sequence":"additional","affiliation":[{"name":"Icelandic Food and Veterinary Authority Selfoss Iceland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Ekman","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences and Veterinary Public Health Swedish University of Agricultural Sciences Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Boyde","sequence":"additional","affiliation":[{"name":"Biophysics, Oral Growth and Development Dental Institute Barts and The London School of Medicine and Dentistry Queen Mary University of London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Hansson","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Swedish University of Agricultural Sciences Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,1,30]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00167-011-1743-2"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.11101359"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.H.01385"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-6226(02)00174-4"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/1751-0147-44-161"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.22203\/eCM.v027a16"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.2746\/0425164044864679"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.74.6.874"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.2011.01908.x"},{"key":"e_1_2_11_11_1","first-page":"84","article-title":"Joint histology by iodine staining","volume":"223","author":"Boyde A.","year":"2013","journal-title":"J. Anat."},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0021-8782.2004.00354.x"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3306.1991.tb03753.x"},{"issue":"31","key":"e_1_2_11_14_1","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1111\/j.2042-3306.1999.tb05316.x","article-title":"Early changes in the distal intertarsal joint of Dutch Warmblood foals and the influence of exercise on bone density in the third tarsal bone","volume":"31","author":"Barneveld A.","year":"1999","journal-title":"Equine Vet. J."},{"key":"e_1_2_11_15_1","doi-asserted-by":"crossref","first-page":"607","DOI":"10.2460\/ajvr.1991.52.04.607","article-title":"Osteochondrosis and juvenile spavin in equids","volume":"52","author":"Watrous B.J.","year":"1991","journal-title":"Am. J. Vet. Res."},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ctep.2006.11.009"},{"key":"e_1_2_11_17_1","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1186\/BF03547782","article-title":"Prevalence and risk factors of bone spavin in Icelandic horses in Sweden: a radiographic field study","volume":"39","author":"Eksell P.","year":"1998","journal-title":"Acta Vet. Scand."},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.2746\/042516400776563590"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.2007.00226.x"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.2007.00230.x"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.2746\/042516407X166756"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.240.9.1109"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3292.2011.00288.x"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3306.1996.tb03114.x"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ctep.2006.11.002"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.2009.01663.x"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.2010.01761.x"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.2004.04087.x"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.1999.tb00353.x"}],"container-title":["Equine Veterinary Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fevj.12370","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/beva.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/evj.12370","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T12:24:14Z","timestamp":1762086254000},"score":1,"resource":{"primary":{"URL":"https:\/\/beva.onlinelibrary.wiley.com\/doi\/10.1111\/evj.12370"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1,30]]},"references-count":28,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["10.1111\/evj.12370"],"URL":"https:\/\/doi.org\/10.1111\/evj.12370","archive":["Portico"],"relation":{},"ISSN":["0425-1644","2042-3306"],"issn-type":[{"type":"print","value":"0425-1644"},{"type":"electronic","value":"2042-3306"}],"subject":[],"published":{"date-parts":[[2015,1,30]]},"assertion":[{"value":"2014-03-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-09-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-01-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}