{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T03:46:03Z","timestamp":1780544763639,"version":"3.54.1"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,2,2]],"date-time":"2015-02-02T00:00:00Z","timestamp":1422835200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["beva.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Equine Veterinary Journal"],"published-print":{"date-parts":[[2015,5]]},"abstract":"Summary<\/jats:title>\n \n Reasons for performing study<\/jats:title>\n \n Furosemide is the most commonly used medication for exercise\u2010induced pulmonary haemorrhage (\n EIPH<\/jats:styled-content>\n ); however, critical evaluation of the strength of evidence for efficacy of furosemide is lacking and is warranted so that evidence\u2010based treatment decisions can be made.\n <\/jats:p>\n <\/jats:sec>\n \n Objectives<\/jats:title>\n \n To evaluate the efficacy of furosemide to reduce the severity or frequency of detection of\n EIPH<\/jats:styled-content>\n in Thoroughbred and Standardbred racehorses.\n <\/jats:p>\n <\/jats:sec>\n \n Study design<\/jats:title>\n Systematic review with meta\u2010analyses.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Primary studies were identified via searches of electronic databases, relevant texts and reference lists of published articles. Studies were not restricted by date or publication status. Only studies published in English were eligible for inclusion. Searches were performed using a predetermined search string. Randomised controlled trials, nonrandomised trials and observational studies were included. Three authors independently assessed each study using the\n C<\/jats:styled-content>\n ochrane collaboration guidelines and\n G<\/jats:styled-content>\n rading of\n R<\/jats:styled-content>\n ecommendations\n A<\/jats:styled-content>\n ssessment,\n D<\/jats:styled-content>\n evelopment and\n E<\/jats:styled-content>\n valuation recommendations for rating quality of evidence. Meta\u2010analysis of studies was performed with pooled data to determine whether furosemide reduced the frequency of detection of\n EIPH<\/jats:styled-content>\n (yes or no) as evaluated by tracheobronchoscopy or bronchoalveolar lavage fluid red blood cell number, or if furosemide reduced the severity of\n EIPH<\/jats:styled-content>\n by at least one tracheobronchoscopic grade.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Seventeen studies fulfilled the inclusion criteria. The relative risk of detecting any\n EIPH<\/jats:styled-content>\n by tracheobronchoscopy after administration of furosemide was 0.88 (pooled data from 11 studies, n = 5780; 95% confidence interval 0.79\u20130.97, P\u2009=\u20090.01). When data from only high\u2010quality randomised controlled trials (2 studies, n = 405) were used, the relative risk of detecting endoscopically evident\n EIPH<\/jats:styled-content>\n was 0.68 (95% confidence interval 0.58\u20130.79, P<0.001). The proportion of horses previously diagnosed with\n EIPH<\/jats:styled-content>\n having a reduction of at least one\n EIPH<\/jats:styled-content>\n grade after furosemide was 68% (2 studies, n = 405; 95% confidence interval 61\u201378%).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n There is high\u2010quality evidence, albeit limited, that administration of furosemide reduces the incidence and severity of\n EIPH<\/jats:styled-content>\n in Thoroughbred or Standardbred racehorses.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/evj.12373","type":"journal-article","created":{"date-parts":[[2014,10,7]],"date-time":"2014-10-07T05:52:26Z","timestamp":1412661146000},"page":"341-349","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["A systematic review and meta\u2010analysis of the efficacy of furosemide for exercise\u2010induced pulmonary haemorrhage in\n T<\/scp>\n horoughbred and\n S<\/scp>\n tandardbred racehorses"],"prefix":"10.1111","volume":"47","author":[{"given":"S. L.","family":"Sullivan","sequence":"first","affiliation":[{"name":"University of Melbourne Werribee Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Whittem","sequence":"additional","affiliation":[{"name":"University of Melbourne Werribee Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. S.","family":"Morley","sequence":"additional","affiliation":[{"name":"Colorado State University Fort Collins USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. W.","family":"Hinchcliff","sequence":"additional","affiliation":[{"name":"University of Melbourne Werribee Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,2,2]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3306.2002.tb05451.x"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.235.1.76"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.2005.66.596"},{"key":"e_1_2_11_5_1","first-page":"743","article-title":"Prevalence, recurrence, risk factors and effects on performance of epistaxis in racing Thoroughbreds in the UK: 914,849 starts (2001\u20132010)","volume":"26","author":"Thomas A.D.","year":"2012","journal-title":"J. Vet. Int. 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