{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T02:57:47Z","timestamp":1792292267165,"version":"4.4.0"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,2,2]],"date-time":"2015-02-02T00:00:00Z","timestamp":1422835200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Research Drive BV (Norg, the Netherlands)"}],"content-domain":{"domain":["beva.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Equine Veterinary Journal"],"published-print":{"date-parts":[[2016,3]]},"abstract":"Summary<\/jats:title>\n \n Reasons for performing study<\/jats:title>\n \n Intra\u2010articular (\n IA<\/jats:styled-content>\n ) injection of corticosteroids with or without hyaluronate (\n HA<\/jats:styled-content>\n ) has been used for decades in equine practice for treatment of noninfectious synovitis and osteoarthritis. However, to date, no large\u2010scale randomised equine field trials have been reported that address the supposed superior clinical efficacy of the combination of corticosteroid +\n HA<\/jats:styled-content>\n compared with\n IA<\/jats:styled-content>\n injection of corticosteroid alone.\n <\/jats:p>\n <\/jats:sec>\n \n Objectives<\/jats:title>\n \n To compare the clinical efficacy of\n IA<\/jats:styled-content>\n triamcinolone acetonide (\n TA<\/jats:styled-content>\n , 12\u2009mg) compared with\n IA TA<\/jats:styled-content>\n (12\u2009mg) + high molecular weight\n HA<\/jats:styled-content>\n (20\u2009mg) in horses with clinical joint disease.\n <\/jats:p>\n <\/jats:sec>\n \n Study design<\/jats:title>\n Prospective, randomised, parallel, open label, multicentre clinical trial.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Eighty client\u2010owned horses from 13 clinics were included. Lameness and effusion scores were assessed at baseline and 3 weeks after\n IA<\/jats:styled-content>\n treatment. A standardised telephone questionnaire was completed between the owner and consulting veterinarian at 3 months. The primary outcome parameter was clinical success rate, defined as \u22652 grades lameness reduction (on a 0\u20135 scale) at 3 weeks. Chi\u2010square statistics and binary logistic regression were used to analyse data on an intention\u2010to\u2010treat basis for the 3 week outcome.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The success rate of\n IA TA<\/jats:styled-content>\n 3 weeks after treatment was 87.8%, while that of\n TA<\/jats:styled-content>\n +\n HA<\/jats:styled-content>\n was 64.1% (P = 0.01). Age >13 years was associated with a reduced success rate for the combination treatment (P = 0.004) at 3 weeks. At 3 months, half the horses in each group had returned to their previous level of performance.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n The combination of TA with HA was associated with a lower short\u2010term clinical success rate and a similar medium\u2010term outcome compared with\n IA<\/jats:styled-content>\n TA, with only half of the horses performing at their previous level of exercise after 3 months regardless of treatment group allocation.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/evj.12383","type":"journal-article","created":{"date-parts":[[2014,11,6]],"date-time":"2014-11-06T07:15:00Z","timestamp":1415258100000},"page":"152-158","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Intra\u2010articular treatment with triamcinolone compared with triamcinolone with hyaluronate: A randomised open\u2010label multicentre clinical trial in 80 lame horses"],"prefix":"10.1111","volume":"48","author":[{"given":"J. C.","family":"de Grauw","sequence":"first","affiliation":[{"name":"Department of Equine Sciences Faculty of Veterinary Medicine Utrecht University The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. C.","family":"Visser\u2010Meijer","sequence":"additional","affiliation":[{"name":"Veterinary Center Honselersdijk The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Lashley","sequence":"additional","affiliation":[{"name":"Equine Clinic de Raaphorst Wassenaar The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Meeus","sequence":"additional","affiliation":[{"name":"Veterinary Clinic Ridderkerk The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. 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