{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T09:41:17Z","timestamp":1785577277025,"version":"3.56.0"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,3,12]],"date-time":"2015-03-12T00:00:00Z","timestamp":1426118400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Virbac Animal Health"}],"content-domain":{"domain":["beva.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Equine Veterinary Journal"],"published-print":{"date-parts":[[2016,5]]},"abstract":"Summary<\/jats:title>\n \n Reasons for performing study<\/jats:title>\n \n \n S<\/jats:styled-content>\n trongylus vulgaris\n <\/jats:italic>\n is a pathogenic helminth parasite infecting horses and was once considered to be the primary cause of colic. Migrating larvae cause ischaemia and infarction of intestinal segments. This knowledge is derived from case reports and experimental inoculations of parasite\u2010na\u00efve foals, and it remains unknown to what extent the parasite is associated with different types of colic.\n <\/jats:p>\n <\/jats:sec>\n \n Objectives<\/jats:title>\n \n To evaluate the role of\n \n S<\/jats:styled-content>\n .\u2009vulgaris\n <\/jats:italic>\n as a risk factor for different types of colic in horses.\n <\/jats:p>\n <\/jats:sec>\n \n Study design<\/jats:title>\n \n A retrospective case\u2013control study among horses referred with abdominal pain to the\n U<\/jats:styled-content>\n niversity of\n C<\/jats:styled-content>\n openhagen\n L<\/jats:styled-content>\n arge\n A<\/jats:styled-content>\n nimal\n T<\/jats:styled-content>\n eaching\n H<\/jats:styled-content>\n ospital during 2009\u20132011.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Each colic case was matched with an equid of the same type (pony, Warmblooded or Coldblooded), age, sex and admitted in the same month and year but for problems unrelated to the gastrointestinal tract. Serum samples were analysed for antibodies to migrating\n \n S<\/jats:styled-content>\n .\u2009vulgaris\n <\/jats:italic>\n larvae using a recently developed enzyme\u2010linked immunosorbent assay (\n ELISA<\/jats:styled-content>\n ). The following 4 case definitions were used: colic\n sensu lato<\/jats:italic>\n , i.e. all horses presenting with colic (n = 274), with further subgroups, i.e. undiagnosed colics (n = 48), strangulating obstructions (n = 76) and nonstrangulating infarctions (n = 20).\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n \n S<\/jats:styled-content>\n trongylus vulgaris\n <\/jats:italic>\n antibody levels were similar to control values in colics\n sensu lato<\/jats:italic>\n and horses with undiagnosed colic. In contrast, nonstrangulating intestinal infarctions were significantly associated with positive\n \n S<\/jats:styled-content>\n .\u2009vulgaris\n <\/jats:italic>\n \u2005\n ELISAs<\/jats:styled-content>\n (odds ratio 5.33, 95% confidence interval 1.03\u201327.76, P = 0.05). Also, horses with nonstrangulating infarctions had a significantly higher occurrence of positive\n ELISAs<\/jats:styled-content>\n than horses with strangulating obstructions (odds ratio 3.79, 95% confidence interval 1.34\u201310.68, P = 0.01) and the colic\n sensu lato<\/jats:italic>\n group (odds ratio 3.09, 95% confidence interval 1.20\u20138.01, P = 0.02).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Nonstrangulating intestinal infarction was strongly associated with\n \n S<\/jats:styled-content>\n .\u2009vulgaris\u2010\n <\/jats:italic>\n specific antibodies, whereas the more broadly defined colic categories were not associated with positive\n ELISA<\/jats:styled-content>\n results. Thus, the\n ELISA<\/jats:styled-content>\n holds potential to become a helpful adjunct in diagnosis and management of horses with colic.\n <\/jats:p>\n \n The Summary is available in Chinese \u2013 see Supporting information.<\/jats:bold>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/evj.12422","type":"journal-article","created":{"date-parts":[[2015,1,21]],"date-time":"2015-01-21T09:11:10Z","timestamp":1421831470000},"page":"376-379","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Nonstrangulating intestinal infarction associated with\n \n S<\/scp>\n <\/i>\n trongylus vulgaris<\/i>\n in referred\n D<\/scp>\n anish equine cases"],"prefix":"10.1111","volume":"48","author":[{"given":"M. K.","family":"Nielsen","sequence":"first","affiliation":[{"name":"Department of Veterinary Science M.H. Gluck Equine Research Center University of Kentucky Lexington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Jacobsen","sequence":"additional","affiliation":[{"name":"Department of Large Animal Sciences University of Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. N.","family":"Olsen","sequence":"additional","affiliation":[{"name":"Department of Large Animal Sciences University of Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Bousquet","sequence":"additional","affiliation":[{"name":"Virbac Carros France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Pihl","sequence":"additional","affiliation":[{"name":"Department of Large Animal Sciences University of Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,3,12]]},"reference":[{"key":"e_1_2_11_2_1","first-page":"569","article-title":"Strongylus vulgaris \u2013 the horse killer","volume":"56","author":"Kester W.O.","year":"1975","journal-title":"Modern Vet. 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