{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T22:13:47Z","timestamp":1790979227652,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,5,4]],"date-time":"2015-05-04T00:00:00Z","timestamp":1430697600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100001003","name":"Boehringer Ingelheim","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001003","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007699","name":"University of Georgia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007699","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["beva.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Equine Veterinary Journal"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Reasons for performing study<\/jats:title>\n                    <jats:p>Pimobendan is an inodilator used in dogs for the management of heart failure due to myxomatous valve disease or dilated cardiomyopathy. The lack of data regarding the effects of pimobendan in horses prevents the rational use of this drug.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To determine the cardiovascular effects of pimobendan in healthy mature horses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study design<\/jats:title>\n                    <jats:p>Randomised experimental study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Five horses were fasted overnight prior to receiving i.v. pimobendan (0.25\u00a0mg\/kg bwt), intragastric (i.g.) pimobendan (0.25\u00a0mg\/kg bwt) or i.g. placebo with a washout period of one week between each administration. Horses were instrumented for the measurement of right ventricular (\n                      <jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content>\n                      ) minimum pressure,\n                      <jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content>\n                      maximum pressure,\n                      <jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content>\n                      end diastolic pressure, and maximum rate of increase and decrease in\n                      <jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content>\n                      pressure before and 0.5, 1, 2, 4, and 8\u00a0h after drug administration. Arterial blood pressure, central venous pressure, cardiac output and heart rate were measured at the same time points. Data were expressed as a maximum percentage of change over baseline values.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      There were no adverse effects associated with administration of pimobendan. The percentage increase in heart rate was significantly greater for horses given pimobendan i.g. (33\u00a0\u00b1\u00a04%) and i.v. (36\u00a0\u00b1\u00a014%) than for those given a placebo (\u22122\u00a0\u00b1\u00a07%). The percentage increase in maximum rate of increase in\n                      <jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content>\n                      pressure (35\u00a0\u00b1\u00a036%) and the percentage decrease in minimum pressure (47\u00a0\u00b1\u00a024%) and end diastolic pressure (34\u00a0\u00b1\u00a013%) were significantly greater in horses given pimobendan i.v. than in those given placebo. Other variables measured were not significantly different between treatment groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Pimobendan administered i.v. has positive chronotropic and inotropic effects in healthy mature horses and warrants further investigation for the treatment of heart failure in horses.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/evj.12432","type":"journal-article","created":{"date-parts":[[2015,3,10]],"date-time":"2015-03-10T03:39:12Z","timestamp":1425958752000},"page":"352-356","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Cardiovascular effects of pimobendan in healthy mature horses"],"prefix":"10.1111","volume":"48","author":[{"given":"T.","family":"Afonso","sequence":"first","affiliation":[{"name":"Department of Large Animal Medicine College of Veterinary Medicine University of Georgia Athens USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Gigu\u00e8re","sequence":"additional","affiliation":[{"name":"Department of Large Animal Medicine College of Veterinary Medicine University of Georgia Athens USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Rapoport","sequence":"additional","affiliation":[{"name":"Department of Small Animal Medicine and Surgery College of Veterinary Medicine University of Georgia Athens USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. H.","family":"Barton","sequence":"additional","affiliation":[{"name":"Department of Large Animal Medicine College of Veterinary Medicine University of Georgia Athens USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. E.","family":"Coleman","sequence":"additional","affiliation":[{"name":"Department of Small Animal Medicine and Surgery College of Veterinary Medicine University of Georgia Athens USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,5,4]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-198900142-00003"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.63.5.911"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00167264"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(86)90733-8"},{"key":"e_1_2_12_6_1","first-page":"S1","article-title":"Hemodynamic profile of the cardiotonic agent pimobendan","volume":"14","author":"Meel J.C.","year":"1989","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2002.tb02366.x"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.2005.tb00302.x"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.5326\/0420249"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2008.0150.x"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2008.0116.x"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2012.01026.x"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2009.0392.x"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-4431.2012.00768.x"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2002.220.1512"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-7020-2817-5.00021-3"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.12197"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.310.6977.446"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3306.2002.tb05468.x"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(69)90005-8"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.1996.tb02087.x"},{"key":"e_1_2_12_22_1","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.2460\/ajvr.1999.60.12.1508","article-title":"Use of right ventricular pressure increase rate to evaluate cardiac contractility in horses","volume":"60","author":"Nollet H.","year":"1999","journal-title":"Am. J. Vet. Res."},{"key":"e_1_2_12_23_1","first-page":"315","volume-title":"Grossman's Cardiac Catheterization, Angiography and Intervention","author":"Grossman W.","year":"2006"},{"key":"e_1_2_12_24_1","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1152\/ajplegacy.1963.205.1.30","article-title":"Hemodynamic determinants of the maximal rate of rise of left ventricular pressure","volume":"205","author":"Wallace A.G.","year":"1963","journal-title":"Am. J. Physiol."},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI104469"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-1-4377-0398-6.00024-X"},{"key":"e_1_2_12_27_1","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0022-3565(24)36774-6","article-title":"The cardiac effects of pimobendan (but not amrinone) are preserved at rest and during exercise in conscious dogs with pacing\u2010induced heart failure","volume":"282","author":"Ohte N.","year":"1997","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"e_1_2_12_28_1","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1097\/00005344-199402000-00014","article-title":"Disparate inotropic and lusitropic responses to pimobendan in conscious dogs with tachycardia\u2010induced heart failure","volume":"23","author":"Asanoi H.","year":"1994","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.67.2.310"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2885.1992.tb01010.x"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2004.tb00166.x"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-198900142-00012"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-198908000-00018"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.1999.tb02158.x"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI108522"},{"key":"e_1_2_12_36_1","doi-asserted-by":"crossref","first-page":"872","DOI":"10.2460\/ajvr.1999.60.07.872","article-title":"Techniques for evaluation of right ventricular relaxation rate in horses and effects of inhalant anesthetics with and without intravenous administration of calcium gluconate","volume":"60","author":"Grubb T.L.","year":"1999","journal-title":"Am. J. Vet. Res."}],"container-title":["Equine Veterinary Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fevj.12432","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fevj.12432","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/beva.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/evj.12432","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T13:55:44Z","timestamp":1762091744000},"score":1,"resource":{"primary":{"URL":"https:\/\/beva.onlinelibrary.wiley.com\/doi\/10.1111\/evj.12432"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5,4]]},"references-count":35,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,5]]}},"alternative-id":["10.1111\/evj.12432"],"URL":"https:\/\/doi.org\/10.1111\/evj.12432","archive":["Portico"],"relation":{},"ISSN":["0425-1644","2042-3306"],"issn-type":[{"value":"0425-1644","type":"print"},{"value":"2042-3306","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,5,4]]},"assertion":[{"value":"2014-12-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-02-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-05-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}