{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T07:27:09Z","timestamp":1767857229452,"version":"3.49.0"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,9,7]],"date-time":"2015-09-07T00:00:00Z","timestamp":1441584000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"University of Florida 2013 Fall Faculty Research Competition"},{"name":"Merial Summer Scholars Program"}],"content-domain":{"domain":["beva.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Equine Veterinary Journal"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Reasons for performing study<\/jats:title>\n                    <jats:p>The mechanism of hyperthermia, a potentially fatal adverse effect of erythromycin treatment of foals, is unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To determine the cause of erythromycin\u2010associated hyperthermia. It was hypothesised that the normal sweat response of foals is impaired by treatment with erythromycin.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study design<\/jats:title>\n                    <jats:p>Blinded, crossover study in 10 healthy pony foals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Foals kept in stalls were given either erythromycin (25\u00a0mg\/kg bwt orally, 3 times daily) or control for 10\u00a0days then turned out for a further 10\u00a0days. Quantitative intradermal terbutaline sweat tests were performed on Days 1 (baseline), 3, 10 and 20. The effects on terbutaline\u2010induced sweating of erythromycin, terbutaline concentration and treatment day were analysed by repeated\u2010measures ANOVA with Bonferroni\u2010corrected pairwise\n                      <jats:italic>post hoc<\/jats:italic>\n                      comparisons. Peak temperatures were compared by Wilcoxon's signed rank test and proportions by McNemar's related samples test. Significance was set at P&lt;0.05.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>There were significant 2\u2010factor interactions for treatment \u00d7 terbutaline after baseline, treatment \u00d7 day at every terbutaline concentration, and day \u00d7 terbutaline for erythromycin (P&lt;0.001) but not control (P\u00a0=\u00a00.9) treatment. Sweating was significantly reduced from baseline in erythromycin\u2010treated foals at all subsequent days. Erythromycin\u2010treated foals produced less sweat at all time\u2010points than did control\u2010treated foals (P&lt;0.05). Peak rectal temperatures of erythromycin\u2010treated foals were significantly higher (P\u00a0=\u00a00.02) than those of controls. During the first 3\u00a0days outside more erythromycin\u2010treated than control\u2010treated foals required treatment for hyperthermia (6 vs. 0; P\u00a0=\u00a00.03).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We believe drug\u2010induced anhidrosis is the likely cause of hyperthermia in some foals treated with erythromycin.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/evj.12481","type":"journal-article","created":{"date-parts":[[2015,7,14]],"date-time":"2015-07-14T19:39:37Z","timestamp":1436902777000},"page":"590-594","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Macrolide\u2010induced hyperthermia in foals: Role of impaired sweat responses"],"prefix":"10.1111","volume":"48","author":[{"given":"A. L.","family":"Stieler","sequence":"first","affiliation":[{"name":"Department of Large Animal Clinical Sciences College of Veterinary Medicine University of Florida Gainesville USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. C.","family":"Sanchez","sequence":"additional","affiliation":[{"name":"Department of Large Animal Clinical Sciences College of Veterinary Medicine University of Florida Gainesville USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. F.","family":"Mallicote","sequence":"additional","affiliation":[{"name":"Department of Large Animal Clinical Sciences College of Veterinary Medicine University of Florida Gainesville USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B. B.","family":"Martabano","sequence":"additional","affiliation":[{"name":"Department of Large Animal Clinical Sciences College of Veterinary Medicine University of Florida Gainesville USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. A.","family":"Burrow","sequence":"additional","affiliation":[{"name":"Department of Large Animal Clinical Sciences College of Veterinary Medicine University of Florida Gainesville USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. J.","family":"MacKay","sequence":"additional","affiliation":[{"name":"Department of Large Animal Clinical Sciences College of Veterinary Medicine University of Florida Gainesville USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,9,7]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2011.00835.x"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-1135(87)90121-0"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvp.12010"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2000.217.68"},{"key":"e_1_2_10_6_1","first-page":"243","article-title":"Hyperthermia in foals treated with erythromycin alone or in combination with rifampicin for respiratory disease during hot environmental conditions","volume":"42","author":"Traub\u2010Dargatz J.","year":"1996","journal-title":"Proc. Am. Ass. 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