{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T11:25:41Z","timestamp":1773055541421,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,9,7]],"date-time":"2015-09-07T00:00:00Z","timestamp":1441584000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Sao Paulo Research Foundation (FAPESP)","award":["2011\/21927-0"],"award-info":[{"award-number":["2011\/21927-0"]}]},{"name":"Sao Paulo Research Foundation (FAPESP)","award":["2010\/08967-0"],"award-info":[{"award-number":["2010\/08967-0"]}]}],"content-domain":{"domain":["beva.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Equine Veterinary Journal"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Reasons for performing study<\/jats:title>\n                    <jats:p>To investigate two protocols to provide antinociception in horses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate the antinociceptive effects of intravenous methadone combined with detomidine or acepromazine in adult horses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study design<\/jats:title>\n                    <jats:p>Randomised, blinded, crossover study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Mechanical, thermal and electrical stimuli were applied to the dorsal left and right metacarpus and coronary band of the left thoracic limb, respectively. A thermal stimulus was applied caudal to the withers. The horses were treated with saline (C), a combination of methadone (0.2\u00a0mg\/kg bwt) and detomidine (10\u00a0\u03bcg\/kg bwt) (\n                      <jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content>\n                      ) or methadone (0.2\u00a0mg\/kg bwt) and acepromazine (0.05\u00a0mg\/kg bwt) (\n                      <jats:styled-content style=\"fixed-case\">MA<\/jats:styled-content>\n                      ) at 1\u00a0week intervals. Nociceptive thresholds were measured before and at 15\u00a0min intervals until 150\u00a0min after treatment. Wilcoxon rank\u2010sum and Wilcoxon signed rank tests were used to compare data between groups at each time point and over time within each group, followed by the Bonferroni method to adjust the P value.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The mechanical stimulus was the most sensitive test to differentiate the antinociceptive effects of the treatments. Mechanical thresholds were greater after\n                      <jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content>\n                      than\n                      <jats:styled-content style=\"fixed-case\">MA<\/jats:styled-content>\n                      between 15 and 30\u00a0min and with both\n                      <jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content>\n                      and\n                      <jats:styled-content style=\"fixed-case\">MA<\/jats:styled-content>\n                      these thresholds were greater than C from 15 to 60\u00a0min. Electrical and thermal limb thresholds were greater after\n                      <jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content>\n                      than C at 15 and 45\u00a0min and at 15, 30, 45, 75 and 105\u00a0min, respectively. Thermal limb thresholds were greater with\n                      <jats:styled-content style=\"fixed-case\">MA<\/jats:styled-content>\n                      than C at 30\u00a0min. Thoracic thermal threshold in\n                      <jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content>\n                      and\n                      <jats:styled-content style=\"fixed-case\">MA<\/jats:styled-content>\n                      were higher than C at 45, 75, 90 and 120\u00a0min and from 30 to 75\u00a0min, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Methadone and acepromazine produced less pronounced mechanical antinociception than\n                      <jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/evj.12483","type":"journal-article","created":{"date-parts":[[2015,7,14]],"date-time":"2015-07-14T19:40:04Z","timestamp":1436902804000},"page":"613-618","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Antinociceptive effects of methadone combined with detomidine or acepromazine in horses"],"prefix":"10.1111","volume":"48","author":[{"given":"C.","family":"Lopes","sequence":"first","affiliation":[{"name":"Department of Anaesthesiology Faculty of Medicine Universidade Estadual Paulista, UNESP Botucatu Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. P. L.","family":"Luna","sequence":"additional","affiliation":[{"name":"Department of Veterinary Surgery and Anaesthesiology Faculty of Veterinary Medicine and Animal Science Universidade Estadual Paulista UNESP, Botucatu Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. 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