{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T14:11:56Z","timestamp":1790863916332,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,10,6]],"date-time":"2015-10-06T00:00:00Z","timestamp":1444089600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"ID.Vet Innovative Diagnostics, Montpellier, France"}],"content-domain":{"domain":["beva.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Equine Veterinary Journal"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Reasons for performing study<\/jats:title>\n                    <jats:p>\n                      Equine viral arteritis (\n                      <jats:styled-content style=\"fixed-case\">EVA<\/jats:styled-content>\n                      ), a disease caused by infection with the equine arteritis virus (\n                      <jats:styled-content style=\"fixed-case\">EAV<\/jats:styled-content>\n                      ), is present in many European countries. In Spain, the last confirmed outbreak was reported in 1992 and there is a paucity of seroprevalence studies. The disease has a major impact on the equine breeding industry, which is mainly represented by Spanish Purebred (\n                      <jats:styled-content style=\"fixed-case\">SP<\/jats:styled-content>\n                      ) horses in Spain.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      To estimate the seroprevalence of\n                      <jats:styled-content style=\"fixed-case\">EAV<\/jats:styled-content>\n                      in the breeding\n                      <jats:styled-content style=\"fixed-case\">SP<\/jats:styled-content>\n                      horse population in central Spain and identify potential horse and studfarm level factors associated with seropositivity to\n                      <jats:styled-content style=\"fixed-case\">EAV<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study design<\/jats:title>\n                    <jats:p>Cross\u2010sectional study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Individual serum samples from 555\n                      <jats:styled-content style=\"fixed-case\">SP<\/jats:styled-content>\n                      horses, collected between September 2011 and November 2013 at 35 studfarms, were tested using a commercially available\n                      <jats:styled-content style=\"fixed-case\">EAV<\/jats:styled-content>\n                      antibody\n                      <jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content>\n                      and seroneutralisation as the World Organisation for Animal Health reference confirmation test for samples with positive and equivocal results. Data on factors putatively associated with seropositivity to\n                      <jats:styled-content style=\"fixed-case\">EAV<\/jats:styled-content>\n                      were collected via a questionnaire and examined using random effects logistic regression for analysis of clustered data.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Equine arteritis virus seroprevalence in the\n                      <jats:styled-content style=\"fixed-case\">SP<\/jats:styled-content>\n                      breeding population in central Spain standardised for the sex distribution of the reference horse population, was estimated to be 16.8% (95% confidence interval 5.2\u201328.5%). Increasing numbers of breeding mares on the studfarm and increasing percentage of mares with reproductive problems during the last 12 months were identified as being positively associated with\n                      <jats:styled-content style=\"fixed-case\">EAV<\/jats:styled-content>\n                      seropositivity. Mares vaccinated against Equine herpesvirus\u20101 (\n                      <jats:styled-content style=\"fixed-case\">EHV<\/jats:styled-content>\n                      \u20101) and\/or \u20104 (\n                      <jats:styled-content style=\"fixed-case\">EHV<\/jats:styled-content>\n                      \u20104) were also positively associated with\n                      <jats:styled-content style=\"fixed-case\">EAV<\/jats:styled-content>\n                      seropositivity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      These findings are of importance to ensure appropriate biosecurity measures for studfarms are carried out and may help facilitate the development of an\n                      <jats:styled-content style=\"fixed-case\">EVA<\/jats:styled-content>\n                      surveillance programme in the\n                      <jats:styled-content style=\"fixed-case\">SP<\/jats:styled-content>\n                      breeding horse population.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/evj.12500","type":"journal-article","created":{"date-parts":[[2015,8,17]],"date-time":"2015-08-17T03:56:46Z","timestamp":1439783806000},"page":"573-577","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Seroprevalence and factors associated with seropositivity to equine arteritis virus in Spanish Purebred horses in Spain"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1142-3944","authenticated-orcid":false,"given":"F.","family":"Cruz","sequence":"first","affiliation":[{"name":"VISAVET Health Surveillance Centre Universidad Complutense Madrid Spain"},{"name":"Departamento de Medicina y Cirug\u00eda Animal Facultad de Veterinaria Universidad Complutense Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Fores","sequence":"additional","affiliation":[{"name":"Departamento de Medicina y Cirug\u00eda Animal Facultad de Veterinaria Universidad Complutense Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Mughini\u2010Gras","sequence":"additional","affiliation":[{"name":"National Institute for Public Health and the Environment (RIVM) Centre for Infectious Disease Control (CIb) Bilthoven The Netherlands"},{"name":"Utrecht University Faculty of Veterinary Medicine Department of Infectious Diseases and Immunology Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Ireland","sequence":"additional","affiliation":[{"name":"Centre for Preventive Medicine Animal Health Trust  Suffolk UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. A.","family":"Moreno","sequence":"additional","affiliation":[{"name":"VISAVET Health Surveillance Centre Universidad Complutense Madrid Spain"},{"name":"Departamento de Sanidad Animal Facultad de Veterinaria Universidad Complutense Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Newton","sequence":"additional","affiliation":[{"name":"Centre for Preventive Medicine Animal Health Trust  Suffolk UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,10,6]]},"reference":[{"key":"e_1_2_12_2_1","first-page":"3","article-title":"Isolation of a filterable agent causing arteritis of horses and abortion by mares; its differentiation from the equine abortion (influenza) virus","volume":"47","author":"Bryans J.T.","year":"1957","journal-title":"Cornell. Vet."},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0749-0739(17)30397-8"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cveq.2014.08.011"},{"key":"e_1_2_12_5_1","first-page":"314","volume-title":"Proceedings of 6th International Conference on Equine Infectious Diseases","author":"Golnik W.","year":"1992"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3306.1992.tb02803.x"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.2746\/042516403775467162"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3306.1997.tb01666.x"},{"key":"e_1_2_12_9_1","first-page":"523","article-title":"Natural equine viral arteritis in foals","volume":"123","author":"Golnik W.","year":"1981","journal-title":"Schweiz. Arch. Tierheilkd."},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/030098588402100311"},{"key":"e_1_2_12_11_1","doi-asserted-by":"crossref","first-page":"769","DOI":"10.2460\/javma.1986.189.07.769","article-title":"Transmissibility and abortogenic effect of equine viral arteritis in mares","volume":"189","author":"Cole J.R.","year":"1986","journal-title":"J. Am. Vet. Med. Ass."},{"key":"e_1_2_12_12_1","first-page":"3","article-title":"Equine viral arteritis: further characterization of the carrier state in stallions","volume":"56","author":"Timoney P.J.","year":"2000","journal-title":"J. Reprod. Fertil. Suppl."},{"key":"e_1_2_12_13_1","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.2460\/ajvr.1981.42.07.1218","article-title":"Pathologic features of horses given a virulent equine arteritis virus intramuscularly","volume":"42","author":"McCollum W.H.","year":"1981","journal-title":"Am. J. Vet. Res."},{"key":"e_1_2_12_14_1","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.2460\/ajvr.1981.42.09.1501","article-title":"Stability of viability and immunizing potency of lyophilized, modified equine arteritis live\u2010virus vaccine","volume":"42","author":"Harry T.O.","year":"1981","journal-title":"Am. J. Vet. Res."},{"key":"e_1_2_12_15_1","first-page":"43","article-title":"Results of an epidemiological investigation on viral arteritis in France and some other European and African countries","volume":"9","author":"Moraillon A.","year":"1978","journal-title":"Ann. Rech. Vet."},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3306.1995.tb03081.x"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2001.219.946"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/00480169.2012.755664"},{"key":"e_1_2_12_19_1","first-page":"5","article-title":"Rhinopneumonia and equine viral arteritis: seroepidemiological study in the northeast of Tunisia","volume":"71","author":"Ghram A.","year":"1994","journal-title":"Arch. Inst. Pasteur Tunis"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2010.09.008"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.145.18.511"},{"key":"e_1_2_12_22_1","first-page":"49","article-title":"Virologico\u2010serologic studies in horses with respiratory tract diseases","volume":"105","author":"Herbst W.","year":"1992","journal-title":"Berl. Munch. Tierarztl. Wochenschr."},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.20506\/rst.33.3.2334"},{"key":"e_1_2_12_24_1","first-page":"20","article-title":"Estudio preliminar de la seroprevalencia de arteritis viral equina en caballos pura raza espa\u00f1ola de la comunidad valenciana [Preliminary study on the seroprevalence of equine viral arteritis in Spanish Purebred horses in the Community of Valencia]","volume":"97","author":"Gimeno Suarep S.","year":"2011","journal-title":"Actualidad Veterinaria"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1080\/09712119.1992.9705906"},{"key":"e_1_2_12_26_1","first-page":"293","article-title":"Studies of an epizootic of equine viral arteritis in racehorses","volume":"2","author":"McCollum W.","year":"1978","journal-title":"J. Equine Med. Surg."},{"key":"e_1_2_12_27_1","unstructured":"Anon(2012)Ministerio de Agricultura Alimentaci\u00f3n y Medio Ambiente. Programa ARCA[Online]. Available at:https:\/\/aplicaciones.magrama.es\/arca-webapp(Accessed 31 December 2013)."},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1127\/0941-2948\/2010\/0430"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1136\/vetreco-2014-000074"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.164.14.437-a"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.161.17.599-a"},{"key":"e_1_2_12_32_1","unstructured":"Senne D.A. Pearson J.E.andCabrey E.A.(1985)Equine viral arteritis: A standard procedure for the virus neutralisation test and comparison of results of a proficiency test performed at five laboratories. Proceedings of the 89th Annual Meeting of the United States Animal Health Association United States Animal Health Association Milwaukee Wisconsin pp.29\u201034."},{"key":"e_1_2_12_33_1","volume-title":"Veterinary Epidemiologic Research","author":"Dohoo I.","year":"2010"},{"key":"e_1_2_12_34_1","unstructured":"Anon(2013a)Daemon Quest by Deloitte: Estudio del Impacto del Sector Ecuestre en Espa\u00f1a[Study on the impact of the Equestrian Sector in Spain]. Real Federacion Hipica Espa\u00f1ola (RFHE) [Online]. Available at:http:\/\/www.rfhe.com\/estudio-global-de-impacto-econo\/(Accessed 20 January 2014)."},{"key":"e_1_2_12_35_1","first-page":"2","article-title":"Equine arteritis virus: clinical symptoms and prevention","volume":"122","author":"Glaser A.L.","year":"1997","journal-title":"Tijdschr. Diergeneeskd."},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1080\/01652176.1979.9693724"},{"key":"e_1_2_12_37_1","unstructured":"Anon(2013)Equine Viral Arteritis. OIE Manual of Diagnostic Tests and Vaccines for Terrestrial Animals 2013. Chapter 2.5.10. [Online]. Available at:http:\/\/www.oie.int\/fileadmin\/Home\/eng\/Health_standards\/tahm\/2.05.10_EVA.pdf(Accessed 20 January 2014)."},{"key":"e_1_2_12_38_1","doi-asserted-by":"crossref","first-page":"839","DOI":"10.2460\/javma.1998.213.06.839","article-title":"Passive transfer, rate of decay, and protein specificity of antibodies against equine arteritis virus in horses from a Standardbred herd with high seroprevalence","volume":"213","author":"Hullinger P.J.","year":"1998","journal-title":"J. Am. Vet. Med. Ass."},{"key":"e_1_2_12_39_1","volume-title":"Equine Respiratory Diseases","author":"Timoney P.","year":"2003"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0023066"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tpb.2013.02.002"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1354\/vp.37-4-287"}],"container-title":["Equine Veterinary Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fevj.12500","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fevj.12500","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/beva.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/evj.12500","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T12:48:51Z","timestamp":1762087731000},"score":1,"resource":{"primary":{"URL":"https:\/\/beva.onlinelibrary.wiley.com\/doi\/10.1111\/evj.12500"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10,6]]},"references-count":41,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,9]]}},"alternative-id":["10.1111\/evj.12500"],"URL":"https:\/\/doi.org\/10.1111\/evj.12500","archive":["Portico"],"relation":{},"ISSN":["0425-1644","2042-3306"],"issn-type":[{"value":"0425-1644","type":"print"},{"value":"2042-3306","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10,6]]},"assertion":[{"value":"2015-01-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-07-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-10-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}