{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:16:17Z","timestamp":1791328577198,"version":"4.3.1"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,2,15]],"date-time":"2016-02-15T00:00:00Z","timestamp":1455494400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001280","name":"Horserace Betting Levy Board","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001280","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["beva.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Equine Veterinary Journal"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Reasons for performing study<\/jats:title>\n                    <jats:p>Synthetic glucocorticoids are used to treat inflammatory conditions in horses. In other pregnant animals, glucocorticoids are given to stimulate fetal maturation with long\u2010term metabolic consequences for the offspring if given preterm. However, their metabolic effects during equine pregnancy remain unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Thus, this study investigated the metabolic effects of dexamethasone administration on pregnant pony mares and their foals after birth.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study design<\/jats:title>\n                    <jats:p>Experimental study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A total of 3 doses of dexamethasone (200\n                      <jats:italic>\u03bc<\/jats:italic>\n                      g\/kg bwt i.m.) were given to 6 pony mares at 48 h intervals beginning at \u2248270 days of pregnancy. Control saline injections were given to 5 mares using the same protocol. After fasting overnight, pancreatic \u03b2 cell responses to exogenous glucose were measured in the mares before, during and after treatment. After birth, pancreatic \u03b2 cell responses to exogenous glucose and arginine were measured in the foals at 2 and 12 weeks.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In mares during treatment, dexamethasone but not saline increased basal insulin concentrations and prolonged the insulin response to exogenous glucose. Basal insulin and glucose concentrations still differed significantly between the 2 groups 72 h post treatment. Dexamethasone treatment significantly reduced placental area but had little effect on foal biometry at birth or subsequently. Foal \u03b2 cell function at 2 weeks was unaffected by maternal treatment. However, by 12 weeks, pancreatic \u03b2 cell sensitivity to arginine, but not glucose, was less in foals delivered by dexamethasone\u2010 than saline\u2010treated mares.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Dexamethasone administration induced changes in maternal insulin\u2010glucose dynamics, indicative of insulin resistance and had subtle longer term effects on post natal \u03b2 cell function of the foals. The programming effects of dexamethasone in horses may be mediated partially by altered maternal metabolism and placental growth.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/evj.12560","type":"journal-article","created":{"date-parts":[[2015,12,28]],"date-time":"2015-12-28T07:17:24Z","timestamp":1451287044000},"page":"99-106","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Effects of maternal dexamethasone treatment on pancreatic \u03b2 cell function in the pregnant mare and post natal foal"],"prefix":"10.1111","volume":"49","author":[{"given":"O. A.","family":"Valenzuela","sequence":"first","affiliation":[{"name":"Department of Physiology, Development and Neuroscience University of Cambridge  CB2 3EG UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. K.","family":"Jellyman","sequence":"additional","affiliation":[{"name":"Department of Physiology, Development and Neuroscience University of Cambridge  CB2 3EG UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V. L.","family":"Allen","sequence":"additional","affiliation":[{"name":"Department of Physiology, Development and Neuroscience University of Cambridge  CB2 3EG UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. B.","family":"Holdstock","sequence":"additional","affiliation":[{"name":"Department of Clinical Veterinary Medicine University of Cambridge  CB2 3EG UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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