{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T06:26:08Z","timestamp":1762323968061,"version":"build-2065373602"},"reference-count":48,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,7,28]],"date-time":"2016-07-28T00:00:00Z","timestamp":1469664000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["beva.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Equine Veterinary Journal"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Reason for performing the study<\/jats:title>\n                    <jats:p>\n                      Investigation of toxicosis caused by\n                      <jats:italic>Malva parviflora<\/jats:italic>\n                      was required after 4 horses from the same farm developed severe muscle fasciculations, tachycardia, sweating and periods of recumbency leading to death or euthanasia after ingesting the plant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      To describe historical, clinical, clinicopathological and pathological findings of 4 horses with suspected\n                      <jats:italic>M. parviflora<\/jats:italic>\n                      toxicosis. The role of cyclopropene fatty acids (found in\n                      <jats:italic>M. parviflora<\/jats:italic>\n                      ) and mechanism for toxicosis are proposed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study design<\/jats:title>\n                    <jats:p>Case series.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Historical, physical examination, clinicopathological and pathological findings are reported. Due to similarities with atypical myopathy or seasonal pasture myopathy acyl carnitine profiles were performed on sera from 2 cases and equine controls. Presence of cyclopropene fatty acids was also examined in sera of 2 cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      <jats:italic>M. parviflora<\/jats:italic>\n                      had been heavily grazed by the horses with little other feed available. Horse 1 deteriorated rapidly and was subjected to euthanasia. Horse 2 was referred to hospital where severe myocardial disease and generalised myopathy was determined; this horse was subjected to euthanasia 36 h after admission. Horse 3 died rapidly and Horse 4 was subjected to euthanasia at onset of clinical signs.\n                      <jats:italic>Post\u2010mortem<\/jats:italic>\n                      examinations performed on 3 horses revealed acute, multifocal cardiac and skeletal myonecrosis. Myocyte glycogen accumulation was absent when examined in Horse 2. Acyl carnitine profiles revealed increased C14\u2013C18 acyl carnitine concentrations in cases relative to controls. Cyclopropene fatty acids were detected in sera of cases but not controls.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      These findings suggest aetiology different to that of atypical myopathy or seasonal pasture myopathy. We hypothesise that cyclopropene fatty acids in\n                      <jats:italic>M. parviflora<\/jats:italic>\n                      interfere with fatty acid \u03b2\u2010oxidation in horses in negative energy balance, causing the clinical signs and abnormal acyl carnitine profiles. These equine cases suggest a pathophysiological course that closely mimics the human genetic condition very long chain acyl CoA dehydrogenase deficiency.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/evj.12604","type":"journal-article","created":{"date-parts":[[2016,6,24]],"date-time":"2016-06-24T11:06:44Z","timestamp":1466766404000},"page":"307-313","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Evidence for marsh mallow (\n                    <i>Malva parviflora<\/i>\n                    ) toxicosis causing myocardial disease and myopathy in four horses"],"prefix":"10.1111","volume":"49","author":[{"given":"J.","family":"Bauquier","sequence":"first","affiliation":[{"name":"Faculty of Veterinary and Agricultural Sciences University of Melbourne Werribee Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Stent","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary and Agricultural Sciences University of Melbourne Werribee Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Gibney","sequence":"additional","affiliation":[{"name":"Victorian Department of Environment and Primary Industries Bundoora Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Jerrett","sequence":"additional","affiliation":[{"name":"Victorian Department of Environment and Primary Industries Bundoora Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"White","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary and Agricultural Sciences University of Melbourne Parkville Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Tennent\u2010Brown","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary and Agricultural Sciences University of Melbourne Werribee Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Pearce","sequence":"additional","affiliation":[{"name":"Golden Plains Equine Bannockburn Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Pitt","sequence":"additional","affiliation":[{"name":"Victorian Clinical Genetics Services Royal Children's Hospital Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,7,28]]},"reference":[{"key":"e_1_2_11_2_1","first-page":"2","article-title":"The biology of Australian weeds 52. Malva Parviflora L","volume":"24","author":"Michael P.J.","year":"2009","journal-title":"Plant Prot. Q."},{"volume-title":"Australia's Poisonous Plants Fungi and Cyanobacteria \u2013 A Guide to Species of Medical and Veterinary Importance","year":"2012","author":"McKenzie R.A.","key":"e_1_2_11_3_1"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0368-1742(22)80005-9"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-0813.2006.tb13396.x"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02533669"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.2298\/ABS1201221T"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02531266"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/179830a0"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1039\/jr9520000313"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3306.2012.00684.x"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/evj.12460"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2005.227.1800"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-540-76698-8_10"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0278-6915(94)00151-D"},{"key":"e_1_2_11_16_1","first-page":"667","volume-title":"Lehninger Principles of Biochemistry","author":"Nelson D.L.","year":"2013"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02666783"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0955-2863(93)90006-I"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1071\/BI9700657"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02532891"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02533184"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/2141244a0"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/53.5.1285"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02540137"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1993.1368"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2013.05.012"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/0925-4439(93)90058-9"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03261931"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.2004.01308.x"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-010-9121-7"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2013.02.002"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0b013e32830dd5a6"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.100.22.2248"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2012.00945.x"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.229.7.1134"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2010.06.018"},{"key":"e_1_2_11_37_1","first-page":"1","volume-title":"Four Range Species not Poisonous to Livestock","author":"Marsh C.D.","year":"1928"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3306.2012.00555.x"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2012.00957.x"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2008.02.007"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.2746\/042516407X157765"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2009.02.007"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmg.2015.01.005"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-012-9542-6"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.5692\/clinicalneurol.50.172"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.4103\/0971-6866.82190"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-010-9105-7"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2010.05.005"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2005.09.003"}],"container-title":["Equine Veterinary Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fevj.12604","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fevj.12604","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/beva.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/evj.12604","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T12:15:52Z","timestamp":1762085752000},"score":1,"resource":{"primary":{"URL":"https:\/\/beva.onlinelibrary.wiley.com\/doi\/10.1111\/evj.12604"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,28]]},"references-count":48,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,5]]}},"alternative-id":["10.1111\/evj.12604"],"URL":"https:\/\/doi.org\/10.1111\/evj.12604","archive":["Portico"],"relation":{},"ISSN":["0425-1644","2042-3306"],"issn-type":[{"type":"print","value":"0425-1644"},{"type":"electronic","value":"2042-3306"}],"subject":[],"published":{"date-parts":[[2016,7,28]]},"assertion":[{"value":"2016-01-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-06-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-07-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}