{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T12:20:29Z","timestamp":1762086029305,"version":"build-2065373602"},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,8,5]],"date-time":"2016-08-05T00:00:00Z","timestamp":1470355200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"CEVA Animal Health and the School of Animal and Veterinary Sciences, Charles Sturt University"}],"content-domain":{"domain":["beva.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Equine Veterinary Journal"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      In human subjects, arytenoid chondritis can be caused by chemical trauma of mucosa attributable to gastro\u2010oesophageal reflux. Although a similar process may be involved in the aetiopathogenesis of arytenoid chondritis in horses, the oesophageal lumen\n                      <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content>\n                      in this species is poorly understood.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      To determine if gastro\u2010oesophageal reflux occurs in horses by characterising oesophageal lumen\n                      <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study design<\/jats:title>\n                    <jats:p>Blinded, randomised, placebo\u2010controlled, crossover, experimental study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Luminal oesophageal\n                      <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content>\n                      in six yearling horses was recorded over four 24 h periods using an ambulatory\n                      <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content>\n                      recorder attached to a catheter with two electrodes (proximal and distal) inserted into the oesophagus. Recordings of\n                      <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content>\n                      were made during three management protocols. Initially, horses grazed in a paddock (Protocol A). Horses were then moved to stables to simulate sale preparation of Thoroughbred yearlings, and were given either omeprazole (Protocol B) or placebo paste (Protocol C) orally once per day. Protocol A was repeated for each horse (after a 13 day washout period) between Protocols B and C. Summary statistics described\n                      <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content>\n                      range and frequency of\n                      <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content>\n                      changes. Associations with predictor variables were investigated using linear mixed\u2010effects models. Data are presented as the mean \u00b1 s.d.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Oesophageal lumen\n                      <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content>\n                      ranged from 4.90 to 9.70 (7.36 \u00b1 0.27 and 7.18 \u00b1 0.24 for the proximal and distal electrodes, respectively) and varied frequently (1.2 \u00b1 0.9 changes\/min and 0.8 \u00b1 0.8 changes\/min for the proximal and distal electrodes, respectively). Oesophageal lumen\n                      <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content>\n                      was associated with time since concentrate feeding, activity and time of day, but not with treatment of omeprazole.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main limitations<\/jats:title>\n                    <jats:p>A small number of horses were used and measurement periods were limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Gastro\u2010oesophageal reflux occurs in clinically normal yearling horses. Although omeprazole had no detectable effect, oesophageal lumen\n                      <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content>\n                      recorded during this study did not fall within the therapeutic range of omeprazole.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/evj.12608","type":"journal-article","created":{"date-parts":[[2016,7,6]],"date-time":"2016-07-06T09:33:47Z","timestamp":1467797627000},"page":"389-394","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Oesophageal lumen\n                    <scp>pH<\/scp>\n                    in yearling horses and effects of management and administration of omeprazole"],"prefix":"10.1111","volume":"49","author":[{"given":"C. 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