{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T12:18:32Z","timestamp":1762085912073,"version":"build-2065373602"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,10,20]],"date-time":"2016-10-20T00:00:00Z","timestamp":1476921600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002341","name":"Suomen Akatemia","doi-asserted-by":"publisher","award":["267551"],"award-info":[{"award-number":["267551"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004092","name":"Kuopion Yliopistollinen Sairaala","doi-asserted-by":"publisher","award":["5041750","5041744"],"award-info":[{"award-number":["5041750","5041744"]}],"id":[{"id":"10.13039\/501100004092","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001829","name":"Universiteit Utrecht","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001829","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["beva.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Equine Veterinary Journal"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Arthroscopic optical coherence tomography (\n                      <jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content>\n                      ) is a promising tool for the detailed evaluation of articular cartilage injuries. However,\n                      <jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content>\n                      \u2010based articular cartilage scoring still relies on the operator's visual estimation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      To test the hypothesis that semi\u2010automated International Cartilage Repair Society (\n                      <jats:styled-content style=\"fixed-case\">ICRS<\/jats:styled-content>\n                      ) scoring of chondral lesions seen in\n                      <jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content>\n                      images could enhance intra\u2010 and interobserver agreement of scoring and its accuracy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study design<\/jats:title>\n                    <jats:p>Validation study using equine cadaver tissue.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Osteochondral samples (n = 99) were prepared from 18 equine metacarpophalangeal joints and imaged using\n                      <jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content>\n                      . Custom\u2010made software was developed for semi\u2010automated\n                      <jats:styled-content style=\"fixed-case\">ICRS<\/jats:styled-content>\n                      scoring of cartilage lesions on\n                      <jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content>\n                      images. Scoring was performed visually and semi\u2010automatically by five observers, and levels of inter\u2010 and intraobserver agreement were calculated. Subsequently,\n                      <jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content>\n                      \u2010based scores were compared with\n                      <jats:styled-content style=\"fixed-case\">ICRS<\/jats:styled-content>\n                      scores based on light microscopy images of the histological sections of matching locations (n = 82).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      When semi\u2010automated scoring of the\n                      <jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content>\n                      images was performed by multiple observers, mean levels of intraobserver and interobserver agreement were higher than those achieved with visual\n                      <jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content>\n                      scoring (83% vs. 77% and 74% vs. 33%, respectively). Histology\u2010based scores from matching regions of interest agreed better with visual\n                      <jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content>\n                      \u2010based scoring than with semi\u2010automated\n                      <jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content>\n                      scoring; however, the accuracy of the software was improved by optimising the threshold combinations used to determine the\n                      <jats:styled-content style=\"fixed-case\">ICRS<\/jats:styled-content>\n                      score.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main limitations<\/jats:title>\n                    <jats:p>Images were obtained from cadavers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Semi\u2010automated scoring software improved the reproducibility of\n                      <jats:styled-content style=\"fixed-case\">ICRS<\/jats:styled-content>\n                      scoring of chondral lesions in\n                      <jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content>\n                      images and made scoring less observer\u2010dependent. The image analysis and segmentation techniques adopted in this study warrant further optimisation to achieve better accuracy with semi\u2010automated\n                      <jats:styled-content style=\"fixed-case\">ICRS<\/jats:styled-content>\n                      scoring. In addition, studies on in vivo applications are required.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/evj.12637","type":"journal-article","created":{"date-parts":[[2016,9,4]],"date-time":"2016-09-04T23:53:23Z","timestamp":1473033203000},"page":"552-555","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Semi\u2010automated International Cartilage Repair Society scoring of equine articular cartilage lesions in optical coherence tomography images"],"prefix":"10.1111","volume":"49","author":[{"given":"N. C. R.","family":"te Moller","sequence":"first","affiliation":[{"name":"Department of Equine Sciences Utrecht University Utrecht the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Pitk\u00e4nen","sequence":"additional","affiliation":[{"name":"Department of Applied Physics University of Eastern Finland Kuopio Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. K.","family":"Sarin","sequence":"additional","affiliation":[{"name":"Department of Applied Physics University of Eastern Finland Kuopio Finland"},{"name":"Diagnostic Imaging Centre Kuopio University Hospital Kuopio Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"V\u00e4\u00e4n\u00e4nen","sequence":"additional","affiliation":[{"name":"Department of Applied Physics University of Eastern Finland Kuopio Finland"},{"name":"Diagnostic Imaging Centre Kuopio University Hospital Kuopio Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Liukkonen","sequence":"additional","affiliation":[{"name":"Department of Applied Physics University of Eastern Finland Kuopio Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I. O.","family":"Afara","sequence":"additional","affiliation":[{"name":"Department of Electrical and Computer Engineering Elizade University Ondo Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. H.","family":"Puhakka","sequence":"additional","affiliation":[{"name":"Department of Applied Physics University of Eastern Finland Kuopio Finland"},{"name":"Diagnostic Imaging Centre Kuopio University Hospital Kuopio Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Brommer","sequence":"additional","affiliation":[{"name":"Department of Equine Sciences Utrecht University Utrecht the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Niemel\u00e4","sequence":"additional","affiliation":[{"name":"Department of Equine and Small Animal Medicine University of Helsinki Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.\u2010M.","family":"Tulamo","sequence":"additional","affiliation":[{"name":"Department of Equine and Small Animal Medicine University of Helsinki Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Arg\u00fcelles Capilla","sequence":"additional","affiliation":[{"name":"Department of Equine and Small Animal Medicine University of Helsinki Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"T\u00f6yr\u00e4s","sequence":"additional","affiliation":[{"name":"Department of Applied Physics University of Eastern Finland Kuopio Finland"},{"name":"Diagnostic Imaging Centre Kuopio University Hospital Kuopio Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,10,20]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_12_2_1","DOI":"10.1016\/B978-1-4160-6069-7.00084-5"},{"doi-asserted-by":"publisher","key":"e_1_2_12_3_1","DOI":"10.1016\/j.knee.2007.02.001"},{"key":"e_1_2_12_4_1","first-page":"285","article-title":"Pathogenetic mechanisms of posttraumatic osteoarthritis: opportunities for early intervention","volume":"4","author":"Kramer W.C.","year":"2011","journal-title":"Int. J. Clin. Exp. Med."},{"doi-asserted-by":"publisher","key":"e_1_2_12_5_1","DOI":"10.1016\/j.tvjl.2016.02.005"},{"doi-asserted-by":"publisher","key":"e_1_2_12_6_1","DOI":"10.1177\/0363546509351143"},{"doi-asserted-by":"publisher","key":"e_1_2_12_7_1","DOI":"10.1007\/s11999-010-1764-z"},{"doi-asserted-by":"publisher","key":"e_1_2_12_8_1","DOI":"10.1302\/0301-620X.43B4.752"},{"doi-asserted-by":"publisher","key":"e_1_2_12_9_1","DOI":"10.1016\/S0749-8063(05)80295-6"},{"doi-asserted-by":"publisher","key":"e_1_2_12_10_1","DOI":"10.2106\/00004623-200300002-00008"},{"doi-asserted-by":"publisher","key":"e_1_2_12_11_1","DOI":"10.1007\/s00402-011-1259-8"},{"doi-asserted-by":"publisher","key":"e_1_2_12_12_1","DOI":"10.1016\/j.tvjl.2013.05.031"},{"doi-asserted-by":"publisher","key":"e_1_2_12_13_1","DOI":"10.3109\/17453674.2014.979312"},{"doi-asserted-by":"publisher","key":"e_1_2_12_14_1","DOI":"10.1186\/1751-0147-56-3"},{"doi-asserted-by":"publisher","key":"e_1_2_12_15_1","DOI":"10.1088\/0031-9155\/54\/22\/006"},{"doi-asserted-by":"publisher","key":"e_1_2_12_16_1","DOI":"10.1177\/001316447303300309"},{"doi-asserted-by":"publisher","key":"e_1_2_12_17_1","DOI":"10.1037\/0033-2909.86.2.420"},{"doi-asserted-by":"publisher","key":"e_1_2_12_18_1","DOI":"10.1080\/02664763.2013.788617"},{"doi-asserted-by":"publisher","key":"e_1_2_12_19_1","DOI":"10.1037\/h0026256"},{"doi-asserted-by":"publisher","key":"e_1_2_12_20_1","DOI":"10.1002\/jor.22828"},{"doi-asserted-by":"publisher","key":"e_1_2_12_21_1","DOI":"10.1016\/j.mri.2008.10.003"},{"doi-asserted-by":"publisher","key":"e_1_2_12_22_1","DOI":"10.1177\/1947603513515998"},{"doi-asserted-by":"publisher","key":"e_1_2_12_23_1","DOI":"10.1186\/1471-2474-11-231"},{"doi-asserted-by":"publisher","key":"e_1_2_12_24_1","DOI":"10.1115\/1.4000991"},{"doi-asserted-by":"publisher","key":"e_1_2_12_25_1","DOI":"10.1177\/1947603510397534"},{"doi-asserted-by":"publisher","key":"e_1_2_12_26_1","DOI":"10.1177\/0363546512472044"},{"doi-asserted-by":"publisher","key":"e_1_2_12_27_1","DOI":"10.1016\/j.joca.2007.05.005"},{"doi-asserted-by":"publisher","key":"e_1_2_12_28_1","DOI":"10.1002\/jor.22673"},{"doi-asserted-by":"publisher","key":"e_1_2_12_29_1","DOI":"10.1016\/j.joca.2015.05.034"},{"doi-asserted-by":"publisher","key":"e_1_2_12_30_1","DOI":"10.1088\/0031-9155\/60\/19\/7747"},{"doi-asserted-by":"publisher","key":"e_1_2_12_31_1","DOI":"10.3109\/03091902.2012.663054"},{"doi-asserted-by":"publisher","key":"e_1_2_12_32_1","DOI":"10.1002\/jbio.201500130"},{"doi-asserted-by":"publisher","key":"e_1_2_12_33_1","DOI":"10.1002\/lpor.201200056"}],"container-title":["Equine Veterinary Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fevj.12637","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fevj.12637","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/beva.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/evj.12637","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T12:14:47Z","timestamp":1762085687000},"score":1,"resource":{"primary":{"URL":"https:\/\/beva.onlinelibrary.wiley.com\/doi\/10.1111\/evj.12637"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,20]]},"references-count":32,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,7]]}},"alternative-id":["10.1111\/evj.12637"],"URL":"https:\/\/doi.org\/10.1111\/evj.12637","archive":["Portico"],"relation":{},"ISSN":["0425-1644","2042-3306"],"issn-type":[{"type":"print","value":"0425-1644"},{"type":"electronic","value":"2042-3306"}],"subject":[],"published":{"date-parts":[[2016,10,20]]},"assertion":[{"value":"2016-03-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-08-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-10-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}