{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T09:41:16Z","timestamp":1785577276835,"version":"3.56.0"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,2,22]],"date-time":"2017-02-22T00:00:00Z","timestamp":1487721600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Bova Compounding"}],"content-domain":{"domain":["beva.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Equine Veterinary Journal"],"published-print":{"date-parts":[[2017,9]]},"abstract":"Summary<\/jats:title>\n \n Background<\/jats:title>\n Esomeprazole warrants further investigation as a treatment for equine gastric ulcer syndrome.<\/jats:p>\n <\/jats:sec>\n \n Objectives<\/jats:title>\n To investigate the duration of intraday acid suppression achieved with two doses of esomeprazole under two dietary conditions.<\/jats:p>\n <\/jats:sec>\n \n Study design<\/jats:title>\n A four way crossover design.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Six adult Thoroughbreds instrumented with percutaneous gastrotomy tubes were used. Intragastric pH was measured for continuous 23 h periods (08.00\u201307.00 h) for 6 consecutive days (Days 0\u20135). Baseline data was recorded on Day 0 and esomeprazole was administered on Days 1\u20135. Two doses (0.5 and 2.0 mg\/kg bwt\/day per os once daily) and two diets (a high grain\/low fibre (\n HG<\/jats:styled-content>\n \/\n LF<\/jats:styled-content>\n ) and ad libitum hay (\n HAY<\/jats:styled-content>\n ) diet) were studied. Data for the percentage of time pH was above 4 (%tpH>4) and median intraday pH was reported for two measurement points and analysed using generalised estimating equations.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n An inconsistent effect of both diet and dose was evident with mean %tpH>4 and mean of the median intraday\n pH<\/jats:styled-content>\n s typically higher at the 2.0 mg\/kg bwt dose and in\n HG<\/jats:styled-content>\n \/\n LF<\/jats:styled-content>\n diet. A cumulative effect of dosing was present with the magnitude of acid suppression observed on Day 5 consistently higher than that observed on Day 1. The magnitude of acid suppression, at measurement point 1, compared favourably with previous reports on omeprazole and exceeded human therapeutic breakpoints for the 0.5 mg\/kg bwt dose in the\n HG<\/jats:styled-content>\n \/\n LF<\/jats:styled-content>\n diet and 2.0 mg\/kg bwt dose in the\n HAY<\/jats:styled-content>\n diet.\n <\/jats:p>\n <\/jats:sec>\n \n Main limitations<\/jats:title>\n Instrumentation may have modified gastric function and horses were not fasted or exercised.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n The findings of the present study suggested that both dose and diet affect the response to esomeprazole in the horse and that a cumulative effect is present over the first 5 days of treatment. Further investigation into the clinical efficacy of esomeprazole and trials directly comparing esomeprazole and omeprazole appear to be warranted.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/evj.12670","type":"journal-article","created":{"date-parts":[[2017,1,24]],"date-time":"2017-01-24T07:25:46Z","timestamp":1485242746000},"page":"637-642","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["The effects of dose and diet on the pharmacodynamics of esomeprazole in the horse"],"prefix":"10.1111","volume":"49","author":[{"given":"B. W.","family":"Sykes","sequence":"first","affiliation":[{"name":"School of Veterinary Science The University of Queensland Gatton Queensland Australia"},{"name":"Bova Compounding Caringbah New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Underwood","sequence":"additional","affiliation":[{"name":"School of Veterinary Science The University of Queensland Gatton Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. C.","family":"Mills","sequence":"additional","affiliation":[{"name":"School of Veterinary Science The University of Queensland Gatton Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,2,22]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3292.1999.tb00961.x"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.13578"},{"key":"e_1_2_11_4_1","first-page":"401","article-title":"Endoscopic findings of the gastric antrum and pylorus in horses: 162 cases (1996\u20102000)","volume":"15","author":"Murray M.J.","year":"2001","journal-title":"J. Vet. Int. Med."},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.2746\/042516409X441910"},{"key":"e_1_2_11_6_1","first-page":"731","article-title":"Prevalence and risk factors for ulceration of the gastric glandular mucosa in Thoroughbred racehorses in training in the UK and Australia","volume":"26","author":"Habershon\u2010Butcher J.L.","year":"2012","journal-title":"J. Vet. Int. Med."},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/evj.12287"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/evj.12083"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/evj.12191"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000200917"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/evj.12630"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2006.03074.x"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2006.09.013"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11894-008-0098-4"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.4.2.253"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2011.0716.x"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jevs.2009.10.006"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/eve.12395"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-0813.2006.00059.x"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvp.12345"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.24.4.270"},{"key":"e_1_2_11_22_1","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/S0022-3565(24)38953-0","article-title":"A turnover model of irreversible inhibition of gastric acid secretion by omeprazole in the dog","volume":"295","author":"Abel\u00f6 A.","year":"2000","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"e_1_2_11_23_1","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1186\/BF03547798","article-title":"Effects of differently composed feeds and physical stress on plasma gastrin concentration in horses","volume":"39","author":"Sandin A.","year":"1998","journal-title":"Acta Vet. Scand."},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1990.tb03679.x"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.2746\/042516403775696339"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3306.1999.tb05171.x"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvp.12169"}],"container-title":["Equine Veterinary Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fevj.12670","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/evj.12670","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/evj.12670","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/beva.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/evj.12670","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T10:01:03Z","timestamp":1762077663000},"score":1,"resource":{"primary":{"URL":"https:\/\/beva.onlinelibrary.wiley.com\/doi\/10.1111\/evj.12670"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,22]]},"references-count":26,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,9]]}},"alternative-id":["10.1111\/evj.12670"],"URL":"https:\/\/doi.org\/10.1111\/evj.12670","archive":["Portico"],"relation":{},"ISSN":["0425-1644","2042-3306"],"issn-type":[{"value":"0425-1644","type":"print"},{"value":"2042-3306","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,22]]},"assertion":[{"value":"2016-09-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-01-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-02-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}