{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:10:01Z","timestamp":1787314201205,"version":"build-2736575974"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,3,29]],"date-time":"2017-03-29T00:00:00Z","timestamp":1490745600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100001655","name":"Grayson-Jockey Club Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001655","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["beva.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Equine Veterinary Journal"],"published-print":{"date-parts":[[2017,9]]},"abstract":"Summary<\/jats:title>\n \n Background<\/jats:title>\n \n Erythromycin (\n ERY<\/jats:styled-content>\n ) induces anhidrosis in foals. Azithromycin (\n AZI<\/jats:styled-content>\n ) and clarithromycin (\n CLA<\/jats:styled-content>\n ), often combined with rifampicin (\n RIF<\/jats:styled-content>\n ), are commonly used to treat\n Rhodococcus equi<\/jats:italic>\n infections, but effects on sweating have not been investigated.\n <\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n \n To determine the effects of\n AZI<\/jats:styled-content>\n ,\n CLA<\/jats:styled-content>\n and\n RIF<\/jats:styled-content>\n on sweat responses in normal foals.\n <\/jats:p>\n <\/jats:sec>\n \n Study design<\/jats:title>\n Each experiment was a blinded, duplicated, six foal \u00d7 three period counterbalanced within subjects design (12 foals\/experiment).<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Antimicrobials were given orally for 5 days. In Experiment 1,\n ERY<\/jats:styled-content>\n ,\n AZI<\/jats:styled-content>\n and\n CLA<\/jats:styled-content>\n were given. In Experiment 2,\n ERY<\/jats:styled-content>\n ,\n RIF<\/jats:styled-content>\n and\n ERY<\/jats:styled-content>\n \/\n RIF<\/jats:styled-content>\n combination were used. Quantitative intradermal terbutaline sweat tests were performed daily for 3 days before and 1, 2, 5, 9, 24, and 39 days after treatment. Data were analysed by repeated measures analysis of variance procedures. Significance was P\u22640.05.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n In Experiment 1, all macrolides suppressed sweating although\n CLA<\/jats:styled-content>\n and\n AZI<\/jats:styled-content>\n were less potent than\n ERY<\/jats:styled-content>\n . In Experiment 2, significant sweat suppression occurred in foals given\n ERY<\/jats:styled-content>\n with or without\n RIF<\/jats:styled-content>\n , but there was no effect of\n RIF<\/jats:styled-content>\n alone. Rifampicin reduced sweat suppression by\n ERY<\/jats:styled-content>\n on Day 1 of treatment but not thereafter.\n <\/jats:p>\n <\/jats:sec>\n \n Main limitations<\/jats:title>\n \n Because\n ERY<\/jats:styled-content>\n blood concentrations were not measured, effects of\n RIF<\/jats:styled-content>\n on\n ERY<\/jats:styled-content>\n \u2010induced anhidrosis could not definitively be ascribed to altered\n ERY<\/jats:styled-content>\n bioavailability.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n All macrolides commonly used to treat\n R. equi<\/jats:italic>\n pneumonia, i.e.\n ERY<\/jats:styled-content>\n ,\n AZI<\/jats:styled-content>\n and\n CLA<\/jats:styled-content>\n , induce anhidrosis in foals. The potent anti\u2010sudorific effect of\n ERY<\/jats:styled-content>\n is delayed, but not substantially affected by concurrent\n RIF<\/jats:styled-content>\n administration.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/evj.12677","type":"journal-article","created":{"date-parts":[[2017,2,26]],"date-time":"2017-02-26T20:46:44Z","timestamp":1488142004000},"page":"624-628","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Effects of clarithromycin, azithromycin and rifampicin on terbutaline\u2010induced sweating in foals"],"prefix":"10.1111","volume":"49","author":[{"given":"A. L.","family":"Stieler Stewart","sequence":"first","affiliation":[{"name":"Department of Large Animal Clinical Sciences College of Veterinary Medicine University of Florida Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. C.","family":"Sanchez","sequence":"additional","affiliation":[{"name":"Department of Large Animal Clinical Sciences College of Veterinary Medicine University of Florida Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. F.","family":"Mallicote","sequence":"additional","affiliation":[{"name":"Department of Large Animal Clinical Sciences College of Veterinary Medicine University of Florida Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. L.","family":"Muniz","sequence":"additional","affiliation":[{"name":"Department of Large Animal Clinical Sciences College of Veterinary Medicine University of Florida Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. S.","family":"Westerterp","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine Utrecht University Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. A.","family":"Burrow","sequence":"additional","affiliation":[{"name":"Department of Large Animal Clinical Sciences College of Veterinary Medicine University of Florida Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. J.","family":"MacKAY","sequence":"additional","affiliation":[{"name":"Department of Large Animal Clinical Sciences College of Veterinary Medicine University of Florida Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,3,29]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2011.00835.x"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-1135(87)90121-0"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvp.12010"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2000.217.68"},{"key":"e_1_2_10_6_1","first-page":"243","article-title":"Hyperthermia in foals treated with erythromycin alone or in combination with rifampicin for respiratory disease during hot environmental conditions","volume":"42","author":"Traub\u2010Dargatz J.","year":"1996","journal-title":"Proc. Am. Assoc. 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