{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T03:57:29Z","timestamp":1790395049032,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,6,19]],"date-time":"2017-06-19T00:00:00Z","timestamp":1497830400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007612","name":"Animal Health Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007612","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["beva.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Equine Veterinary Journal"],"published-print":{"date-parts":[[2017,11]]},"abstract":"Summary<\/jats:title>\n \n Background<\/jats:title>\n \n Equine atypical myopathy (\n AM<\/jats:styled-content>\n ) is a toxic rhabdomyolysis associated with ingestion of hypoglycin A, derived typically in Europe, from\n Acer pseudoplatanus<\/jats:italic>\n tree. Despite the wide distribution of this tree species in the\n UK<\/jats:styled-content>\n , the number of cases reported annually varies, and there has been an apparent increase in prevalence in recent years. Although\n AM<\/jats:styled-content>\n was first recognised in the\n UK<\/jats:styled-content>\n , epidemiological studies have never been conducted focused solely on this country.\n <\/jats:p>\n <\/jats:sec>\n \n Objectives<\/jats:title>\n \n To describe the spatiotemporal distribution, presentation, treatment and outcome of\n AM<\/jats:styled-content>\n cases reported in the\n UK<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Study design<\/jats:title>\n Retrospective case series.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n British\n AM<\/jats:styled-content>\n cases reported to the atypical myopathy alert website, between 2011 and 2015 were included (n = 224). Data were obtained via standardised epidemiological questionnaires from owners and veterinarians. Factors associated with survival were assessed using logistic regression.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Most cases reported were from England (87.9%). Survival was 38.6% (n = 73\/189). Clinical factors associated with reduced odds of survival included, hypothermia (odds ratio [\n OR<\/jats:styled-content>\n ] 0.18; 95% confidence interval [\n CI<\/jats:styled-content>\n ] 0.06\u20130.57; P = 0.01), bladder distension (\n OR<\/jats:styled-content>\n 0.11;\n CI<\/jats:styled-content>\n 0.02\u20130.59; P = 0.01), tachycardia (\n OR<\/jats:styled-content>\n 0.97;\n CI<\/jats:styled-content>\n 0.94\u20130.99; P = 0.04) and serum creatine kinase activity >100,000 IU\/L (\n OR<\/jats:styled-content>\n 0.17;\n CI<\/jats:styled-content>\n 0.04\u20130.68; P = 0.01) in the univariable analysis as well as recumbency. The latter was the only sign retained in multivariable analysis (\n OR<\/jats:styled-content>\n = 0.19;\n CI<\/jats:styled-content>\n 0.06\u20130.62; P = 0.006). Administration of vitamins during the disease was associated with survival (\n OR<\/jats:styled-content>\n 3.75;\n CI<\/jats:styled-content>\n 1.21\u201311.57; P = 0.02).\n <\/jats:p>\n <\/jats:sec>\n \n Main limitations<\/jats:title>\n \n Reporting cases to the Atypical Myopathy Alert Group is voluntary; therefore, under\u2010reporting will result in underestimation of\n AM<\/jats:styled-content>\n cases; furthermore, direct owner\u2010reporting could have introduced misdiagnosis bias.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Some areas of the\n UK<\/jats:styled-content>\n reported\n AM<\/jats:styled-content>\n cases more commonly. Clinical signs such as recumbency, rectal temperature, distended bladder and serum creatine kinase activity might be useful prognostic indicators though should be considered in the context of the clinical picture. Treatment with vitamins increases odds of survival.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/evj.12694","type":"journal-article","created":{"date-parts":[[2017,4,26]],"date-time":"2017-04-26T10:53:13Z","timestamp":1493203993000},"page":"746-752","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Equine atypical myopathy in the\n UK<\/scp>\n : Epidemiological characteristics of cases reported from 2011 to 2015 and factors associated with survival"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6854-7879","authenticated-orcid":false,"given":"S.","family":"Gonz\u00e1lez\u2010Medina","sequence":"first","affiliation":[{"name":"Comparative Neuromuscular Diseases Laboratory The Royal Veterinary College London UK"},{"name":"Epidemiology and Disease Surveillance Animal Health Trust Newmarket Suffolk, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. L.","family":"Ireland","sequence":"additional","affiliation":[{"name":"Epidemiology and Disease Surveillance Animal Health Trust Newmarket Suffolk, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. J.","family":"Piercy","sequence":"additional","affiliation":[{"name":"Comparative Neuromuscular Diseases Laboratory The Royal Veterinary College London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. R.","family":"Newton","sequence":"additional","affiliation":[{"name":"Epidemiology and Disease Surveillance Animal Health Trust Newmarket Suffolk, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. M.","family":"Votion","sequence":"additional","affiliation":[{"name":"Equine Medicine Department Pole Equine Faculty of Veterinary Medicine University of Li\u00e8ge Li\u00e8ge Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,6,19]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/evj.12499"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0136785"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.12367"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3306.2012.00684.x"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.13927"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3292.2012.00441.x"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3292.2012.00439.x"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-4431.2010.00574.x"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3306.2012.00556.x"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2008.01.016"},{"key":"e_1_2_12_12_1","first-page":"354","article-title":"Myoglobinuria in horses","volume":"54","author":"Bowen J.N.","year":"1942","journal-title":"Vet. Rec."},{"key":"e_1_2_12_13_1","unstructured":"University of Liege B.(2016). Available at:http:\/\/labos.ulg.ac.be\/myopathie-atypique Atypical myopathy alert group (Accessed February 17 2016)."},{"key":"e_1_2_12_14_1","volume-title":"Arboles y arbustos de la Espa\u00f1a peninsular","author":"Ceballos y Fern\u00e1ndez de C\u00f3rdoba L.","year":"1971"},{"key":"e_1_2_12_15_1","doi-asserted-by":"crossref","unstructured":"Herrera C.M. Jordano P. Guiti\u00e1n J.andTraveset A.(1998)Annual variability in seed production by woody plants and the masting concept: reassessment of principles and relationship to pollination and seed dispersal.The University of Chicago Press Chicago IL. p 576.","DOI":"10.2307\/2463358"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3306.2012.00555.x"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2008.03.023"},{"key":"e_1_2_12_18_1","unstructured":"Network N.B.(2016). Available at:https:\/\/data.nbn.org.uk\/Taxa\/NBNSYS0000003191\/Grid_Map(Accessed February 11 2016)."},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/1746-6148-8-43"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.21836\/PEM19970104"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2007.tb01962.x"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2012.00957.x"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2008.02.007"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-013-9611-5"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2015.06.072"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20881"},{"key":"e_1_2_12_27_1","volume-title":"Comprehensive Physiology","author":"Saltin B.","year":"2010"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.2174\/092986710793205462"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)50710-9"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2016.07.015"},{"key":"e_1_2_12_31_1","first-page":"E359","article-title":"Carnitine effects on coenzyme A profiles in rat liver with hypoglycin inhibition of multiple dehydrogenases","volume":"272","author":"Lieu Y.K.","year":"1997","journal-title":"Am. J. Physiol."},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(73)90284-0"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mito.2016.06.005"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI111387"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.35.7.1041"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4165(64)90242-9"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(76)90139-8"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)68697-7"}],"container-title":["Equine Veterinary Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fevj.12694","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/beva.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/evj.12694","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T09:14:13Z","timestamp":1762074853000},"score":1,"resource":{"primary":{"URL":"https:\/\/beva.onlinelibrary.wiley.com\/doi\/10.1111\/evj.12694"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,19]]},"references-count":37,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["10.1111\/evj.12694"],"URL":"https:\/\/doi.org\/10.1111\/evj.12694","archive":["Portico"],"relation":{},"ISSN":["0425-1644","2042-3306"],"issn-type":[{"value":"0425-1644","type":"print"},{"value":"2042-3306","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,19]]},"assertion":[{"value":"2016-08-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-04-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-06-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}