{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T16:24:45Z","timestamp":1784046285204,"version":"3.55.0"},"reference-count":48,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,7,12]],"date-time":"2017-07-12T00:00:00Z","timestamp":1499817600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"The American Holistic Veterinary Medicine Association"}],"content-domain":{"domain":["beva.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Equine Veterinary Journal"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Anecdotally, aloe vera is used to treat gastric ulceration, although no studies have yet investigated its efficacy in horses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To test the hypothesis that aloe vera would be noninferior to omeprazole in the treatment of equine gastric ulcer syndrome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study design<\/jats:title>\n                    <jats:p>Randomised, blinded clinical trial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Forty horses with grade \u22652 lesions of the squamous and\/or glandular mucosa were randomly assigned to one of two groups. Horses received either aloe vera inner leaf gel (17.6 mg\/kg bwt) b.i.d. or omeprazole (4 mg\/kg bwt) s.i.d. for approximately 28 days, after which a repeat gastroscopic examination was performed to determine disease resolution. Horses with persistent lesions were offered a further 28 days of treatment with omeprazole (4 mg\/kg bwt s.i.d.) and were re\u2010examined on completion of treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Efficacy analyses were based on 39 horses that completed the trial. Equine squamous gastric disease (\n                      <jats:styled-content style=\"fixed-case\">ESGD<\/jats:styled-content>\n                      ) was observed in 38 horses; improvement and healing rates in these horses were 56% and 17%, respectively, in the aloe vera group, and 85% and 75%, respectively, in the omeprazole group. Healing was less likely to occur in horses with prolonged gastric emptying. Equine glandular gastric disease (\n                      <jats:styled-content style=\"fixed-case\">EGGD<\/jats:styled-content>\n                      ) was less common than\n                      <jats:styled-content style=\"fixed-case\">ESGD<\/jats:styled-content>\n                      (n = 14) and numbers were too small to perform meaningful statistical analyses. The hypothesis that aloe vera would be noninferior to omeprazole was not supported.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main limitations<\/jats:title>\n                    <jats:p>\n                      No placebo control group was included. Limited numbers preclude any comment on the efficacy of aloe vera in the treatment of\n                      <jats:styled-content style=\"fixed-case\">EGGD<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Treatment with aloe vera was inferior to treatment with omeprazole.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/evj.12706","type":"journal-article","created":{"date-parts":[[2017,5,28]],"date-time":"2017-05-28T09:13:01Z","timestamp":1495962781000},"page":"34-40","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Comparison of aloe vera and omeprazole in the treatment of equine gastric ulcer syndrome"],"prefix":"10.1111","volume":"50","author":[{"given":"J.","family":"Bush","sequence":"first","affiliation":[{"name":"School of Animal and Veterinary Science Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"van den Boom","sequence":"additional","affiliation":[{"name":"School of Animal and Veterinary Science Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6761-5371","authenticated-orcid":false,"given":"S.","family":"Franklin","sequence":"additional","affiliation":[{"name":"School of Animal and Veterinary Science Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,7,12]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.2460\/javma.1999.215.08.1130","article-title":"Prevalence of gastric ulcers in show horses","volume":"215","author":"McClure S.R.","year":"1999","journal-title":"J. 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