{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T12:23:52Z","timestamp":1771331032374,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100014737","name":"Szent Istv\u00e1n University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100014737","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["beva.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Equine Veterinary Journal"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Gastrointestinal and other systemic diseases of Equidae are often characterised by partial or complete inappetence. The catabolic processes may lead to lipid mobilisation and other metabolic disturbances. Evidence from earlier studies has revealed that during feed deprivation\/inappetence, the conjugation of bilirubin is reduced causing a substantial rise of the total bilirubin and its unconjugated fraction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      We hypothesised that during feed deprivation, the serum concentration of free fatty acids (\n                      <jats:styled-content style=\"fixed-case\">FFA<\/jats:styled-content>\n                      ), triglycerides (\n                      <jats:styled-content style=\"fixed-case\">TG<\/jats:styled-content>\n                      ), blood urea nitrogen (\n                      <jats:styled-content style=\"fixed-case\">BUN<\/jats:styled-content>\n                      ), total bilirubin (\n                      <jats:styled-content style=\"fixed-case\">tBIL<\/jats:styled-content>\n                      ), total bile acids (\n                      <jats:styled-content style=\"fixed-case\">tBA<\/jats:styled-content>\n                      ) and activity of\n                      <jats:styled-content style=\"fixed-case\">GGT<\/jats:styled-content>\n                      and\n                      <jats:styled-content style=\"fixed-case\">GLDH<\/jats:styled-content>\n                      increases, while the concentration of insulin and direct bilirubin (\n                      <jats:styled-content style=\"fixed-case\">dBIL<\/jats:styled-content>\n                      ) decreases.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study design<\/jats:title>\n                    <jats:p>Observational experiment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Eleven horses were feed deprived for 96 h. Animals were closely monitored while blood samples were taken at the beginning, and then at 72, 84 and 96 h later. Variables of interest included serum\n                      <jats:styled-content style=\"fixed-case\">FFA<\/jats:styled-content>\n                      ,\n                      <jats:styled-content style=\"fixed-case\">TG<\/jats:styled-content>\n                      , insulin,\n                      <jats:styled-content style=\"fixed-case\">GGT<\/jats:styled-content>\n                      ,\n                      <jats:styled-content style=\"fixed-case\">GLDH<\/jats:styled-content>\n                      , total and direct BIL (t&amp;d\n                      <jats:styled-content style=\"fixed-case\">BIL<\/jats:styled-content>\n                      ),\n                      <jats:styled-content style=\"fixed-case\">tBA<\/jats:styled-content>\n                      and\n                      <jats:styled-content style=\"fixed-case\">BUN<\/jats:styled-content>\n                      . The data were analysed by descriptive statistics, paired\n                      <jats:italic>t<\/jats:italic>\n                      \u2010test and one\u2010way repeated measures\n                      <jats:styled-content style=\"fixed-case\">ANOVA<\/jats:styled-content>\n                      with post\u2010hoc\n                      <jats:styled-content style=\"fixed-case\">HSD<\/jats:styled-content>\n                      test, and P\u22640.05 was considered significant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Horses tolerated feed restriction without complications. During this time, the concentration of\n                      <jats:styled-content style=\"fixed-case\">TG<\/jats:styled-content>\n                      ,\n                      <jats:styled-content style=\"fixed-case\">FFA<\/jats:styled-content>\n                      ,\n                      <jats:styled-content style=\"fixed-case\">BUN<\/jats:styled-content>\n                      ,\n                      <jats:styled-content style=\"fixed-case\">dBIL<\/jats:styled-content>\n                      and insulin significantly increased (P\u22640.05), as well as the activity of serum\n                      <jats:styled-content style=\"fixed-case\">GGT<\/jats:styled-content>\n                      , while the concentration of\n                      <jats:styled-content style=\"fixed-case\">tBIL<\/jats:styled-content>\n                      ,\n                      <jats:styled-content style=\"fixed-case\">tBA<\/jats:styled-content>\n                      and the activity of\n                      <jats:styled-content style=\"fixed-case\">GLDH<\/jats:styled-content>\n                      did not change significantly (P&gt;0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main limitations<\/jats:title>\n                    <jats:p>Sample size, lack of serum volatile fatty acid, cortisol and blood glucose measurements may have limited the value of the study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Healthy Akhal Teke horses did not develop a catabolic crisis following 4 days of feed restriction and hyperlipaemia did not occur. Total\n                      <jats:styled-content style=\"fixed-case\">BIL<\/jats:styled-content>\n                      and\n                      <jats:styled-content style=\"fixed-case\">tBA<\/jats:styled-content>\n                      did not increase, thus were not useful indicators of inappetence in this group of horses.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/evj.12730","type":"journal-article","created":{"date-parts":[[2017,8,4]],"date-time":"2017-08-04T07:13:58Z","timestamp":1501830838000},"page":"98-103","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Effect of feed deprivation on selected parameters of lipid mobilisation and hepatic function in healthy Akhal Teke horses"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8509-8822","authenticated-orcid":false,"given":"B.","family":"T\u00f3th","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Auth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Rompos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z.","family":"Bakos","sequence":"additional","affiliation":[{"name":"Department and Clinic of Equine Medicine University of Veterinary Medicine \u00dcll\u0151 Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,9]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0737-0806(07)80253-X"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cveq.2008.12.002"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0396.2007.00798.x"},{"key":"e_1_2_11_5_1","first-page":"12","article-title":"Nutritional support of the sick adult horse","volume":"5","author":"Geor R.J.","year":"2000","journal-title":"World Equine Vet. 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