{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T16:48:01Z","timestamp":1762102081050,"version":"build-2065373602"},"reference-count":17,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,9,13]],"date-time":"2017-09-13T00:00:00Z","timestamp":1505260800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["beva.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Equine Veterinary Journal"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      There have been no previous studies correlating high\u2010field magnetic resonance imaging (\n                      <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>\n                      ) findings with gross and histological post\u2010mortem examination in horses with hindlimb proximal suspensory desmopathy (\n                      <jats:styled-content style=\"fixed-case\">PSD<\/jats:styled-content>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      To determine if adhesions between the suspensory ligament (\n                      <jats:styled-content style=\"fixed-case\">SL<\/jats:styled-content>\n                      ) and adjacent tissues could be detected using high\u2010field\n                      <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>\n                      and if collagen, adipose tissue and muscle pathology could be differentiated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study design<\/jats:title>\n                    <jats:p>Retrospective study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Nineteen horses with hindlimb\n                      <jats:styled-content style=\"fixed-case\">PSD<\/jats:styled-content>\n                      were humanely destroyed; 12 limbs of 11 horses with\n                      <jats:styled-content style=\"fixed-case\">PSD<\/jats:styled-content>\n                      underwent high\u2010field\n                      <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>\n                      . All lame limbs were examined grossly and all\n                      <jats:styled-content style=\"fixed-case\">SL<\/jats:styled-content>\n                      s were examined histologically. The\n                      <jats:styled-content style=\"fixed-case\">MR<\/jats:styled-content>\n                      and histological images were graded blindly. Statistical analysis used a numerical Bayesian approach to simultaneously determine a pathology rating and the contribution of each\n                      <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>\n                      , gross post\u2010mortem and histological observation to this measure.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Signal intensity (\n                      <jats:styled-content style=\"fixed-case\">SI<\/jats:styled-content>\n                      ) in the collagenous tissue was abnormal in 2\/12 limbs. Abnormalities of\n                      <jats:styled-content style=\"fixed-case\">SI<\/jats:styled-content>\n                      in the adipose tissue and muscle were identified in 6 and 11 limbs, respectively. Adhesions between the\n                      <jats:styled-content style=\"fixed-case\">SL<\/jats:styled-content>\n                      and adjacent tissues were suspected in eight limbs, but only confirmed in six limbs. Histopathological observations of abnormal muscle tissue were associated most closely with the measure of disease used in the study and were abnormal in every limb. Gross adhesions were also a sensitive indicator, along with changes to nerves which were observed in 10 limbs. Assessments of adipose tissue signal intensity and muscle tissue signal homogeneity in both lobes of the suspensory ligament were the\n                      <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>\n                      indicators most closely associated with the measure of disease.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main limitations<\/jats:title>\n                    <jats:p>Small sample size. Model assumption that all abnormalities reflected degrees of a single disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Adhesion formation between the\n                      <jats:styled-content style=\"fixed-case\">SL<\/jats:styled-content>\n                      and adjacent structures was detected by high\u2010field\n                      <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>\n                      with reasonable accuracy. Muscle and adipose tissue pathology was identified either alone or in association with collagenous tissue pathology.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/evj.12756","type":"journal-article","created":{"date-parts":[[2017,8,31]],"date-time":"2017-08-31T07:35:27Z","timestamp":1504164927000},"page":"159-165","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Proximal suspensory desmopathy in hindlimbs: Magnetic resonance imaging, gross post\u2010mortem and histological study"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4774-7497","authenticated-orcid":false,"given":"S.","family":"Dyson","sequence":"first","affiliation":[{"name":"Centre for Equine Studies Animal Health Trust Newmarket, Suffolk UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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