{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:38:43Z","timestamp":1787315923537,"version":"build-2736575974"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,11,28]],"date-time":"2017-11-28T00:00:00Z","timestamp":1511827200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007699","name":"University of Georgia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007699","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["beva.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Equine Veterinary Journal"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Despite the paucity of data available, orally administered angiotensin\u2010converting enzyme (\n                      <jats:styled-content style=\"fixed-case\">ACE<\/jats:styled-content>\n                      ) inhibitors are empirically used in horses with valvular regurgitation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Evaluate the echocardiographic and hormonal changes in response to oral benazepril in horses with left\u2010sided valvular regurgitation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study design<\/jats:title>\n                    <jats:p>Prospective, randomised double\u2010blind, placebo\u2010controlled trial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Horses with mitral valve (\n                      <jats:styled-content style=\"fixed-case\">MR<\/jats:styled-content>\n                      ) and\/or aortic valve regurgitation (\n                      <jats:styled-content style=\"fixed-case\">AR<\/jats:styled-content>\n                      ) received oral benazepril (n = 6) at a dosage of 1 mg\/kg q 12 h or a placebo (n = 5) for 28 days. Echocardiography was performed before drug administration and after 28 days of treatment. Plasma renin activity, serum\n                      <jats:styled-content style=\"fixed-case\">ACE<\/jats:styled-content>\n                      activity, angiotensin\n                      <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>\n                      concentration, aldosterone concentration and biochemical variables were measured before drug administration and after 7 and 28 days of treatment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Relative to baseline, horses treated with benazepril had statistically significant reduction in left ventricular internal diameter in systole (mean difference between groups = \u22120.97 cm; 95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      = \u22121.5 to \u22120.43 cm), aortic sinus diameter (\u22120.31 cm; \u22120.54 to \u22120.07 cm), and percentage of the aortic annulus diameter occupied by the base of the\n                      <jats:styled-content style=\"fixed-case\">AR<\/jats:styled-content>\n                      jet (\u221217.05%; \u221231.17 to \u22122.93%) compared with horses receiving a placebo. In addition, horses treated with benazepril had a significantly greater increase in cardiac output (11.95 L\/min; 1.17\u201322.73 L\/min) and fractional shortening (7.59%; 3.3\u201311.88%) compared with horses receiving a placebo. Despite profound serum\n                      <jats:styled-content style=\"fixed-case\">ACE<\/jats:styled-content>\n                      inhibition, renin activity and concentrations of angiotensin\n                      <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>\n                      and aldosterone were not significantly different between treatment groups or among time points.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main limitations<\/jats:title>\n                    <jats:p>Very small sample size and short treatment period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Treatment with oral benazepril resulted in statistically significant echocardiographic changes that might indicate reduced cardiac afterload in horses with left\u2010sided valvular regurgitation. Additional studies with a larger sample size will be necessary to determine if administration of benazepril is beneficial in horses with valvular regurgitation.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>The Summary is available in Spanish \u2013 see Supporting Information<\/jats:bold>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/evj.12773","type":"journal-article","created":{"date-parts":[[2017,10,17]],"date-time":"2017-10-17T08:24:49Z","timestamp":1508228689000},"page":"446-451","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Preliminary investigation of orally administered benazepril in horses with left\u2010sided valvular regurgitation"],"prefix":"10.1111","volume":"50","author":[{"given":"T.","family":"Afonso","sequence":"first","affiliation":[{"name":"Department of Large Animal Medicine College of Veterinary Medicine University of Georgia Athens Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8182-7146","authenticated-orcid":false,"given":"S.","family":"Gigu\u00e8re","sequence":"additional","affiliation":[{"name":"Department of Large Animal Medicine College of Veterinary Medicine University of Georgia Athens Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. 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