{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T20:00:22Z","timestamp":1774900822109,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,3,26]],"date-time":"2018-03-26T00:00:00Z","timestamp":1522022400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Hagyard Equine Medical Institute"}],"content-domain":{"domain":["beva.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Equine Veterinary Journal"],"published-print":{"date-parts":[[2018,9]]},"abstract":"Summary<\/jats:title>\n \n Background<\/jats:title>\n \n Salmonella enterica<\/jats:italic>\n is an important cause of healthcare\u2010associated infections in veterinary hospitals \u2013 with outbreaks of multi\u2010drug resistant (\n MDR<\/jats:styled-content>\n )\n Salmonella<\/jats:italic>\n among equine cases resulting in high case fatality rates and substantial financial cost.\n <\/jats:p>\n <\/jats:sec>\n \n Objectives<\/jats:title>\n \n Study objectives were to 1) investigate factors associated with shedding of\n MDR<\/jats:styled-content>\n \u2010\n Salmonella enterica<\/jats:italic>\n and 2) evaluate the effect shedding may have on health outcomes of previously hospitalised horses and their stablemates.\n <\/jats:p>\n <\/jats:sec>\n \n Study design<\/jats:title>\n Retrospective case\u2013control study with prospective cohort study.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Analysis of medical records (N\u00a0=\u00a0373; 94 culture positive, 279 culture negative) was undertaken to determine factors associated with shedding of\n MDR<\/jats:styled-content>\n \u2010\n Salmonella<\/jats:italic>\n . Additionally, a follow\u2010up study was conducted to assess long\u2010term outcomes associated with shedding among previously hospitalised horses and their stablemates. Data regarding exposures of interest were collected retrospectively from medical records. Information on long\u2010term outcomes was obtained by phone interview of owners. Multivariable regression techniques were used to investigate factors associated with shedding and subsequent health outcomes.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Horses experiencing diarrhoea during hospitalisation were more likely to shed\n Salmonella<\/jats:italic>\n (\n OR<\/jats:styled-content>\n 1.88; 95%\n CI<\/jats:styled-content>\n 1.02, 3.45) compared with horses without diarrhoea, but isolates tended to be susceptible strains. Antimicrobial therapy during hospitalisation was not associated with shedding or recovery of\n MDR<\/jats:styled-content>\n strains. Shedding did not increase long\u2010term risk for non\u2010survival, colic or abnormal faeces after hospital discharge; nor increase risk for hospitalisation or occurrence of abnormal faeces in stablemates.\n <\/jats:p>\n <\/jats:sec>\n \n Main limitations<\/jats:title>\n Data collection was reliant upon the quality of medical records and owner recall, which may have led to information bias. The study population was derived from central Kentucky and may differ from horse populations in other regions.<\/jats:p>\n <\/jats:sec>\n \n Conclusions and clinical importance<\/jats:title>\n \n In general,\n Salmonella<\/jats:italic>\n shedding was not associated with decreased average survival times or impacts to health of stablemates, perhaps due to owner implemented biosecurity precautions. Regardless, recently hospitalised horses should be segregated after discharge, in addition to employing rigorous hygiene practices.\n <\/jats:p>\n \n The Summary is available in Spanish \u2013 see<\/jats:bold>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/evj.12823","type":"journal-article","created":{"date-parts":[[2018,2,27]],"date-time":"2018-02-27T13:52:54Z","timestamp":1519739574000},"page":"616-623","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Factors associated with equine shedding of multi\u2010drug\u2010resistant\n Salmonella enterica<\/i>\n and its impact on health outcomes"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8580-3395","authenticated-orcid":false,"given":"B. A.","family":"Burgess","sequence":"first","affiliation":[{"name":"Department of Population Health College of Veterinary Medicine University of Georgia Athens Georgia USA"},{"name":"Department of Clinical Sciences College of Veterinary Medicine and Biomedical Sciences Colorado State University Fort Collins Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Bauknecht","sequence":"additional","affiliation":[{"name":"Hagyard Equine Medical Institute Lexington Kentucky USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. M.","family":"Slovis","sequence":"additional","affiliation":[{"name":"Hagyard Equine Medical Institute Lexington Kentucky USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. S.","family":"Morley","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences College of Veterinary Medicine and Biomedical Sciences Colorado State University Fort Collins Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,3,26]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.233.5.767"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2010.0546.x"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.234.1.108"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2010.0484.x"},{"key":"e_1_2_10_6_1","unstructured":"Burgess B.A.andMorley P.S.(2013)Factors associated with large animal inpatient shedding of Salmonella enterica in a veterinary teaching hospital. In94th Annual Conference of Research Workers in Animal Diseases. 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