{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T22:41:15Z","timestamp":1781736075524,"version":"3.54.5"},"reference-count":78,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,3,30]],"date-time":"2018-03-30T00:00:00Z","timestamp":1522368000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["beva.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Equine Veterinary Journal"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Osteochondrosis (\n                    <jats:styled-content style=\"fixed-case\">OC<\/jats:styled-content>\n                    ) is an injury to cartilage canals with a following necrosis in the growth cartilage, from there it can develop to osteochondrosis dissecans (\n                    <jats:styled-content style=\"fixed-case\">OCD<\/jats:styled-content>\n                    ). Due to its high impact in the equine industry, new insights into predisposing factors and potential high\u2010risk genetic variants are warranted. This article reviews advancements in quantitative and molecular genetics in refining estimation of genetic parameters and identifying predisposing genetic loci. Heritabilities were highest for hock\n                    <jats:styled-content style=\"fixed-case\">OC<\/jats:styled-content>\n                    with estimates at 0.29\u20130.46 in Hanoverian warmblood and Norwegian trotters, whereas in Thoroughbreds only very low genetic variation seemed to be present in hock\n                    <jats:styled-content style=\"fixed-case\">OC<\/jats:styled-content>\n                    lesions. Whole genome scans using the Illumina Equine\n                    <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>\n                    50 or\n                    <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>\n                    70 Beadchip were performed in Thoroughbred, Standardbred, French and Norwegian trotter, Hanoverian and Dutch warmblood. Validation studies in Spanish Purebred and Hanoverian warmblood horses corroborated\n                    <jats:styled-content style=\"fixed-case\">OC<\/jats:styled-content>\n                    risk loci on\n                    <jats:styled-content style=\"fixed-case\">ECA<\/jats:styled-content>\n                    3, 14, 27 and 29. Particularly, a strong association with hock\u2010\n                    <jats:styled-content style=\"fixed-case\">OCD<\/jats:styled-content>\n                    was found for a single nucleotide polymorphism (\n                    <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>\n                    ) on horse chromosome (\n                    <jats:styled-content style=\"fixed-case\">ECA<\/jats:styled-content>\n                    ) 3 upstream to the\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">LCORL<\/jats:styled-content>\n                    <\/jats:italic>\n                    gene. Gene expression and micro\n                    <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\n                    analyses may be helpful to understand pathophysiological processes in equine\n                    <jats:styled-content style=\"fixed-case\">OC<\/jats:styled-content>\n                    and to connect\n                    <jats:styled-content style=\"fixed-case\">OCD<\/jats:styled-content>\n                    \u2010associated genomic regions with potential candidate genes. Furthermore progress in elucidating the underlying genetic variants and pathophysiological changes in\n                    <jats:styled-content style=\"fixed-case\">OC<\/jats:styled-content>\n                    may be expected from whole genome\n                    <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content>\n                    and\n                    <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\n                    next\u2010generation sequencing studies.\n                  <\/jats:p>","DOI":"10.1111\/evj.12824","type":"journal-article","created":{"date-parts":[[2018,3,2]],"date-time":"2018-03-02T11:46:49Z","timestamp":1519991209000},"page":"556-563","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Genetic risk factors for osteochondrosis in various horse breeds"],"prefix":"10.1111","volume":"50","author":[{"given":"F.","family":"Naccache","sequence":"first","affiliation":[{"name":"University of Veterinary Medicine Hannover, Foundation Institute for Animal Breeding and Genetics Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2089-8933","authenticated-orcid":false,"given":"J.","family":"Metzger","sequence":"additional","affiliation":[{"name":"University of Veterinary Medicine Hannover, Foundation Institute for Animal Breeding and Genetics Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3516-836X","authenticated-orcid":false,"given":"O.","family":"Distl","sequence":"additional","affiliation":[{"name":"University of Veterinary Medicine Hannover, Foundation Institute for Animal Breeding and Genetics Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,3,30]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2013.03.035"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2013.03.036"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ctep.2006.08.002"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2013.03.043"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.101034"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/00480169.2005.36591"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prevetmed.2009.02.018"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1354\/vp.44-4-429"},{"key":"e_1_2_14_10_1","first-page":"128","article-title":"Review: Genetische Aspekte der Osteochondrosis (dissecans), palmare\/plantare osteochondrale Fragmente, r\u00f6ntgenologische Ver\u00e4nderungen der Strahlbeine und degenerativen Gelenkerkrankungen des Pferdes","volume":"13","author":"Hilla D.","year":"2013","journal-title":"Prakt. 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