{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T16:17:03Z","timestamp":1770221823071,"version":"3.49.0"},"reference-count":36,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,3,4]],"date-time":"2019-03-04T00:00:00Z","timestamp":1551657600000},"content-version":"am","delay-in-days":343,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#am"},{"start":{"date-parts":[[2018,3,26]],"date-time":"2018-03-26T00:00:00Z","timestamp":1522022400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","award":["DE140100135"],"award-info":[{"award-number":["DE140100135"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","award":["DP180102418"],"award-info":[{"award-number":["DP180102418"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["beva.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Equine Veterinary Journal"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Equine insulin dysregulation (ID) is a common and poorly understood disorder that increases the risk of laminitis. Recent data show that the condition may be associated with alteration of the enteroinsular axis and enhanced glucose bioavailability. Upregulation of glucagon\u2010like peptide\u20102 (GLP\u20102), an intestinotrophic peptide, leads to enhanced nutrient uptake and metabolic dysfunction in other species.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The study aimed to 1) determine whether GLP\u20102 is differentially expressed in insulin\u2010dysregulated ponies, compared with healthy ponies, and 2) confirm intestinal expression of the GLP\u20102 receptor in horses (eGLP\u20102R).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study design<\/jats:title>\n                    <jats:p>Cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Fasting and post\u2010prandial GLP\u20102 concentrations were measured in archived plasma samples obtained from 25 mixed\u2010breed ponies during two feeding studies. Measurements were undertaken with an ELISA that was validated for equine use as part of the current study. Ponies were designated as healthy or insulin\u2010dysregulated based on an oral glucose test, and the results were compared between groups. The gene expression of the eGLP\u20102R was determined with polymerase chain reaction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Basal, fasted plasma GLP\u20102 concentrations were higher in ponies with ID, compared with healthy ponies. Grazing increased GLP\u20102 in healthy, but not in insulin\u2010dysregulated, ponies. The eGLP\u20102R gene was expressed in the small intestine and pancreas.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main limitations<\/jats:title>\n                    <jats:p>The study was performed with a relatively small sample size. The specificity of the GLP\u20102 assay could not be determined due to the lack of equine\u2010specific assay standards.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study has demonstrated that GLP\u20102 may be important in the pathogenesis of equine ID and suggests that the eGLP\u20102R may be a novel therapeutic target for the treatment of equine ID.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/evj.12825","type":"journal-article","created":{"date-parts":[[2018,3,4]],"date-time":"2018-03-04T07:56:36Z","timestamp":1520150196000},"page":"842-847","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Glucagon\u2010like peptide\u20102: A potential role in equine insulin dysregulation"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7922-3642","authenticated-orcid":false,"given":"M. A.","family":"de Laat","sequence":"first","affiliation":[{"name":"Science and Engineering Faculty Queensland University of Technology (QUT) Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5801-4427","authenticated-orcid":false,"given":"D. M.","family":"Fitzgerald","sequence":"additional","affiliation":[{"name":"Science and Engineering Faculty Queensland University of Technology (QUT) Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2837-5456","authenticated-orcid":false,"given":"M. N.","family":"Sillence","sequence":"additional","affiliation":[{"name":"Science and Engineering Faculty Queensland University of Technology (QUT) Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5731-6602","authenticated-orcid":false,"given":"R. 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