{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T08:58:00Z","timestamp":1789721880737,"version":"4.0.1"},"reference-count":44,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,4,16]],"date-time":"2019-04-16T00:00:00Z","timestamp":1555372800000},"content-version":"am","delay-in-days":340,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#am"},{"start":{"date-parts":[[2018,5,11]],"date-time":"2018-05-11T00:00:00Z","timestamp":1525996800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000199","name":"U.S. Department of Agriculture","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000199","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001655","name":"Grayson-Jockey Club Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001655","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005166","name":"Ohio State University Press","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["beva.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Equine Veterinary Journal"],"published-print":{"date-parts":[[2018,11]]},"abstract":"Summary<\/jats:title>\n \n Background<\/jats:title>\n \n Fibroblast growth factor\u201023 (\n FGF<\/jats:styled-content>\n \u201023) and klotho are key regulators of vitamin D and parathyroid hormone (\n PTH<\/jats:styled-content>\n ) synthesis as well as phosphorus and calcium homeostasis; however, information on the\n FGF<\/jats:styled-content>\n \u201023\/klotho axis in healthy and hospitalised foals is lacking.\n <\/jats:p>\n <\/jats:sec>\n \n Objectives<\/jats:title>\n \n The aims of this study were to measure serum\n FGF<\/jats:styled-content>\n \u201023 and klotho concentrations and determine their association with serum phosphorus, total calcium (\n TC<\/jats:styled-content>\n a), vitamin D metabolite [25(\n OH<\/jats:styled-content>\n )D, 1,25(\n OH<\/jats:styled-content>\n )\n 2<\/jats:sub>\n D],\n PTH<\/jats:styled-content>\n , and aldosterone concentrations, disease severity, and mortality in hospitalised foals.\n <\/jats:p>\n <\/jats:sec>\n \n Study design<\/jats:title>\n Prospective, multicentre, cross\u2010sectional study.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n A total of 91 foals \u226472 h old were classified as hospitalised (n = 81; 58 septic; 23 sick non\u2010septic [\n SNS<\/jats:styled-content>\n ]) and healthy (n = 10). Blood samples were collected on admission. Hormone concentrations were determined by immunoassays.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Serum\n FGF<\/jats:styled-content>\n \u201023,\n PTH<\/jats:styled-content>\n , phosphorus, and aldosterone concentrations were higher while klotho, 25(\n OH<\/jats:styled-content>\n )D, 1,25(\n OH<\/jats:styled-content>\n )\n 2<\/jats:sub>\n D, and\n TC<\/jats:styled-content>\n a concentrations were lower in septic and\n SNS<\/jats:styled-content>\n compared to healthy foals (P<0.05). In hospitalised and septic foals, increased\n FGF<\/jats:styled-content>\n \u201023 and aldosterone concentrations were associated with high phosphorus and\n PTH<\/jats:styled-content>\n but not with\n TC<\/jats:styled-content>\n a and vitamin D metabolite concentrations. Hospitalised foals with the highest\n FGF<\/jats:styled-content>\n \u201023 and lowest klotho concentrations were more likely to die (odds ratio (\n OR<\/jats:styled-content>\n ): 3.3; 95% confidence interval (\n CI<\/jats:styled-content>\n ): 1.1\u201310.3 and\n OR<\/jats:styled-content>\n : 3.1;\n CI<\/jats:styled-content>\n : 1.1\u20138.0, respectively).\n <\/jats:p>\n <\/jats:sec>\n \n Main limitations<\/jats:title>\n Blood gas, ionised calcium, blood culture information not being available for many foals, and use of the sepsis score to classify hospitalised foals.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Imbalances in the\n FGF<\/jats:styled-content>\n \u201023\/klotho axis may contribute to mineral dyshomeostasis and disease progression in critically ill foals. Elevated\n FGF<\/jats:styled-content>\n \u201023 and reduced klotho, together with high phosphorus and\n PTH<\/jats:styled-content>\n concentrations suggests\n FGF<\/jats:styled-content>\n \u201023 resistance.\n FGF<\/jats:styled-content>\n \u201023 and klotho are good markers of disease severity and likelihood of mortality in hospitalised foals. Aldosterone may influence phosphorus and\n PTH<\/jats:styled-content>\n dynamics in hospitalised foals. Routine measurement of phosphorus concentrations in sick foals is recommended.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/evj.12946","type":"journal-article","created":{"date-parts":[[2018,4,16]],"date-time":"2018-04-16T12:16:02Z","timestamp":1523880962000},"page":"739-746","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["The\n FGF<\/scp>\n \u201023\/klotho axis and its relationship with phosphorus, calcium, vitamin D,\n PTH<\/scp>\n , aldosterone, severity of disease, and outcome in hospitalised foals"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7409-0227","authenticated-orcid":false,"given":"A. M.","family":"Kamr","sequence":"first","affiliation":[{"name":"College of Veterinary Medicine The Ohio State University Columbus Ohio USA"},{"name":"Faculty of Veterinary Medicine University of Sadat City Sadat City Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. A.","family":"Dembek","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine The Ohio State University Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"B. E.","family":"Hildreth","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine The Ohio State University Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. R.","family":"Morresey","sequence":"additional","affiliation":[{"name":"Rood and Riddle Equine Hospital Lexington Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. A.","family":"Rathgeber","sequence":"additional","affiliation":[{"name":"Hagyard Equine Medical Institute Lexington Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. A.","family":"Burns","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine The Ohio State University Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. A.","family":"Zaghawa","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine University of Sadat City Sadat City Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. 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