{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T10:04:50Z","timestamp":1789639490245,"version":"4.0.0"},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,12,3]],"date-time":"2018-12-03T00:00:00Z","timestamp":1543795200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["beva.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Equine Veterinary Journal"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Pituitary pars intermedia dysfunction (\n                      <jats:styled-content style=\"fixed-case\">PPID<\/jats:styled-content>\n                      ) is a commonly described endocrine disorder in higher latitudes of the Northern hemisphere but the description of the disease at lower latitudes and in the Southern hemisphere is limited.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      Document the clinical features of\n                      <jats:styled-content style=\"fixed-case\">PPID<\/jats:styled-content>\n                      at different Australian latitudes and climates, and investigate factors associated with survival, laminitis and insulin dysregulation (\n                      <jats:styled-content style=\"fixed-case\">ID<\/jats:styled-content>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study design<\/jats:title>\n                    <jats:p>Retrospective study of 274 equids from eight institutions across Australia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A diagnosis of\n                      <jats:styled-content style=\"fixed-case\">PPID<\/jats:styled-content>\n                      was based on endogenous\n                      <jats:styled-content style=\"fixed-case\">ACTH<\/jats:styled-content>\n                      , overnight dexamethasone suppression test, thyrotropin\u2010releasing hormone stimulation test or necropsy. Clinical and clinicopathologic characteristics of\n                      <jats:styled-content style=\"fixed-case\">PPID<\/jats:styled-content>\n                      and therapeutic responses were investigated. Laminitis was diagnosed by radiographic or histologic changes and\n                      <jats:styled-content style=\"fixed-case\">ID<\/jats:styled-content>\n                      was diagnosed based on endogenous insulin, an oral glucose test or a 2\u2010step insulin\u2010response test.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Being a pony, having a higher body condition score and pergolide administration were associated with survival. The clinical presentation of\n                      <jats:styled-content style=\"fixed-case\">PPID<\/jats:styled-content>\n                      changed with latitude and climate, with anhidrosis and polyuria\/polydipsia more commonly recognised at lower latitudes. Laminitis was diagnosed in 89.9% of cases and\n                      <jats:styled-content style=\"fixed-case\">ID<\/jats:styled-content>\n                      was present in 76.5% of cases in which they were investigated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main limitations<\/jats:title>\n                    <jats:p>Despite the sample size, the lack of uniform testing at all locations (primary or referral cases) and the incompleteness of data sets limited the power of the statistical analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      <jats:styled-content style=\"fixed-case\">PPID<\/jats:styled-content>\n                      can present with variable signs at different latitudes and climates, and\n                      <jats:styled-content style=\"fixed-case\">ID<\/jats:styled-content>\n                      should be investigated in equids diagnosed with\n                      <jats:styled-content style=\"fixed-case\">PPID<\/jats:styled-content>\n                      . Adequate body condition and administration of pergolide are fundamental in\n                      <jats:styled-content style=\"fixed-case\">PPID<\/jats:styled-content>\n                      management.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/evj.13041","type":"journal-article","created":{"date-parts":[[2018,11,12]],"date-time":"2018-11-12T03:39:38Z","timestamp":1541993978000},"page":"440-445","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":59,"title":["Factors associated with survival, laminitis and insulin dysregulation in horses diagnosed with equine pituitary pars intermedia dysfunction"],"prefix":"10.1111","volume":"51","author":[{"given":"R.","family":"Horn","sequence":"first","affiliation":[{"name":"School of Veterinary Science The University of Queensland Gatton Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7675-9126","authenticated-orcid":false,"given":"N. J.","family":"Bamford","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary and Agricultural Sciences The University of Melbourne Werribee Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Afonso","sequence":"additional","affiliation":[{"name":"School of Animal and Veterinary Sciences The University of Adelaide Roseworthy South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Sutherland","sequence":"additional","affiliation":[{"name":"Gisborne Veterinary Clinic Gisborne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Buckerfield","sequence":"additional","affiliation":[{"name":"Hobart Equine Practice Hobart Tasmania Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. H. 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