{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T23:31:53Z","timestamp":1782430313018,"version":"3.54.5"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,12,18]],"date-time":"2018-12-18T00:00:00Z","timestamp":1545091200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2014\/00474\u20105"],"award-info":[{"award-number":["2014\/00474\u20105"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2017\/01425\u20106"],"award-info":[{"award-number":["2017\/01425\u20106"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["beva.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Equine Veterinary Journal"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Standing surgery avoids the risks of general anaesthesia in horses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To assess sedation, antinociception and gastrointestinal motility in standing horses after a detomidine loading dose and 2\u2010h constant rate intravenous (i.v.) infusion, with or without methadone.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study design<\/jats:title>\n                    <jats:p>Blinded, randomised, crossover with seven healthy adult cross\u2010bred horses, three geldings and four females (404\u00a0\u00b1\u00a022\u00a0kg).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Five i.v. treatments were administered to all horses with 1\u2010week washout period: saline (\n                      <jats:styled-content style=\"fixed-case\">SAL<\/jats:styled-content>\n                      ), detomidine low (2.5\u00a0\u03bcg\/kg bwt\u00a0+\u00a06.25\u00a0\u03bcg\/kg bwt\/h) (\n                      <jats:styled-content style=\"fixed-case\">DL<\/jats:styled-content>\n                      ) and high doses (5\u00a0\u03bcg\/kg bwt\u00a0+\u00a012.5\u00a0\u03bcg\/kg bwt\/h) (\n                      <jats:styled-content style=\"fixed-case\">DH<\/jats:styled-content>\n                      ) alone or combined with methadone (0.2\u00a0mg\/kg bwt\u00a0+\u00a00.05\u00a0mg\/kg bwt\/h), (\n                      <jats:styled-content style=\"fixed-case\">DLM<\/jats:styled-content>\n                      ) and (\n                      <jats:styled-content style=\"fixed-case\">DHM<\/jats:styled-content>\n                      ), respectively. Height of head above the ground (\n                      <jats:styled-content style=\"fixed-case\">HHAG<\/jats:styled-content>\n                      ), electrical (\n                      <jats:styled-content style=\"fixed-case\">ET<\/jats:styled-content>\n                      ), thermal (\n                      <jats:styled-content style=\"fixed-case\">TT<\/jats:styled-content>\n                      ) and mechanical (\n                      <jats:styled-content style=\"fixed-case\">MT<\/jats:styled-content>\n                      ) nociceptive thresholds and gastrointestinal motility were evaluated at predetermined times between 5 and 240\u00a0min. A mixed effect model and Kruskal\u2013Wallis test were used to analyse normally and non\u2010normally distributed data, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Sedation (&lt;50% basal\n                      <jats:styled-content style=\"fixed-case\">HHAG<\/jats:styled-content>\n                      ) was achieved for the duration of the infusion, and for an additional 15\u00a0min in\n                      <jats:styled-content style=\"fixed-case\">DH<\/jats:styled-content>\n                      and\n                      <jats:styled-content style=\"fixed-case\">DHM<\/jats:styled-content>\n                      groups. Nociceptive thresholds were higher than baseline, to the greatest degree and the longest duration, with\n                      <jats:styled-content style=\"fixed-case\">DHM<\/jats:styled-content>\n                      (\n                      <jats:styled-content style=\"fixed-case\">ET<\/jats:styled-content>\n                      and\n                      <jats:styled-content style=\"fixed-case\">TT<\/jats:styled-content>\n                      for 135\u00a0min and\n                      <jats:styled-content style=\"fixed-case\">MT<\/jats:styled-content>\n                      for 150\u00a0min). After\n                      <jats:styled-content style=\"fixed-case\">DH<\/jats:styled-content>\n                      ,\n                      <jats:styled-content style=\"fixed-case\">TT<\/jats:styled-content>\n                      was significantly higher than baseline from 30 to 120\u00a0min and\n                      <jats:styled-content style=\"fixed-case\">MT<\/jats:styled-content>\n                      from 15 to 135\u00a0min. After\n                      <jats:styled-content style=\"fixed-case\">DLM<\/jats:styled-content>\n                      ,\n                      <jats:styled-content style=\"fixed-case\">ET<\/jats:styled-content>\n                      was increased at 90\u00a0min,\n                      <jats:styled-content style=\"fixed-case\">TT<\/jats:styled-content>\n                      at 30\u00a0min and\n                      <jats:styled-content style=\"fixed-case\">MT<\/jats:styled-content>\n                      for 120\u00a0min. Gastrointestinal motility was reduced for up to 135\u00a0min after\n                      <jats:styled-content style=\"fixed-case\">DL<\/jats:styled-content>\n                      , 150\u00a0min after\n                      <jats:styled-content style=\"fixed-case\">DLM<\/jats:styled-content>\n                      and 210\u00a0min after\n                      <jats:styled-content style=\"fixed-case\">DH<\/jats:styled-content>\n                      and\n                      <jats:styled-content style=\"fixed-case\">DHM<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main limitations<\/jats:title>\n                    <jats:p>Nociceptive thresholds are not equivalent to surgical stimuli.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Methadone with the highest detomidine dose (\n                      <jats:styled-content style=\"fixed-case\">DHM<\/jats:styled-content>\n                      ) may provide sufficient sedation and analgesia for standing surgical procedures and warrants further investigation.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/evj.13054","type":"journal-article","created":{"date-parts":[[2018,11,28]],"date-time":"2018-11-28T13:26:26Z","timestamp":1543411586000},"page":"530-536","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Sedative and antinociceptive effects of different detomidine constant rate infusions, with or without methadone in standing horses"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1391-0989","authenticated-orcid":false,"given":"M.","family":"Gozalo\u2010Marcilla","sequence":"first","affiliation":[{"name":"S\u00e3o Paulo State University (UNESP), School of Veterinary Medicine and Animal Science Botucatu S\u00e3o Paulo Brazil"},{"name":"The Royal (Dick) School of Veterinary Studies and the Roslin Institute The University of Edinburgh Midlothian UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. R.","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"S\u00e3o Paulo State University (UNESP), School of Veterinary Medicine and Animal Science Botucatu S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. W.","family":"Fonseca","sequence":"additional","affiliation":[{"name":"S\u00e3o Paulo State University (UNESP), School of Veterinary Medicine and Animal Science Botucatu S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0118-6164","authenticated-orcid":false,"given":"F. S.","family":"Possebon","sequence":"additional","affiliation":[{"name":"S\u00e3o Paulo State University (UNESP), School of Veterinary Medicine and Animal Science Botucatu S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Pelligand","sequence":"additional","affiliation":[{"name":"Royal Veterinary College North Mymms, Hatfield Hertfordshire UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. M.","family":"Taylor","sequence":"additional","affiliation":[{"name":"Taylor Monroe Ely Cambridgeshire UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. P. L.","family":"Luna","sequence":"additional","affiliation":[{"name":"S\u00e3o Paulo State University (UNESP), School of Veterinary Medicine and Animal Science Botucatu S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,12,18]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/inp.e6423"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/inp.e7507"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/rvsc.1998.0274"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-2995.2011.00681.x"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-2995.2011.00653.x"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.104359"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.d5333"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.2004.65.357"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1467-2995.2003.00097.x"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/vaa.12316"},{"key":"e_1_2_12_12_1","unstructured":"Haunhorst F.R. Bienert\u2010Zeit A. Hopster K. Gergeleit H.andK\u00e4stner S.B.(2017)Comparison of the effect of buprenorphine or butorphanol on quality of detomidine sedation for cheek tooth extraction and postoperative pain in horses.Proceedings of the Association of Veterinary Anaesthetists (AVA) Autumn Meeting Berlin Germany 10\u201011 November p.84."},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1467-2987.2001.00047.x"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaa.2017.03.009"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/psp.2012.4"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/evj.13031"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jevs.2013.07.012"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/evj.12483"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/evj.12700"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-2995.2012.00784.x"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/evj.12332"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/0023677215577313"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/vaa.12274"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.67.6.992"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1177\/1049909110373508"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/evj.12442"}],"container-title":["Equine Veterinary Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fevj.13054","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/evj.13054","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/evj.13054","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/beva.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/evj.13054","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T10:29:37Z","timestamp":1762079377000},"score":1,"resource":{"primary":{"URL":"https:\/\/beva.onlinelibrary.wiley.com\/doi\/10.1111\/evj.13054"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,18]]},"references-count":25,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["10.1111\/evj.13054"],"URL":"https:\/\/doi.org\/10.1111\/evj.13054","archive":["Portico"],"relation":{},"ISSN":["0425-1644","2042-3306"],"issn-type":[{"value":"0425-1644","type":"print"},{"value":"2042-3306","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12,18]]},"assertion":[{"value":"2017-12-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-11-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-12-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}