{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:10:05Z","timestamp":1787166605325,"version":"build-2736575974"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,4,5]],"date-time":"2019-04-05T00:00:00Z","timestamp":1554422400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["beva.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Equine Veterinary Journal"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Ulcerative keratitis with peripheral furrow formation is a poorly\u2010described condition which has been associated with a grave prognosis due to rapid necrosis of the cornea.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To describe the infectious aetiologies associated with furrow\u2010forming ulcerative keratitis, its overall clinical course and the efficacy of medical and surgical intervention in horses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study design<\/jats:title>\n                    <jats:p>Retrospective clinical case series.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Medical records of 72 horses which presented with furrow\u2010forming ulcerative keratitis at the University of Florida between 1987 and 2015 were reviewed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Seventy\u2010two horses (72 eyes) with furrow\u2010forming ulcerative keratitis were treated at the University of Florida between 1987 and 2015. Of these, a definitive aetiologic diagnosis was available for 37 eyes. Ten of 37 eyes (27%) were diagnosed with fungal keratitis based on cytology of corneal scraping, culture, histopathology and\/or fungal\n                      <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>\n                      . Fourteen of 37 eyes (38%) were diagnosed with a mixed fungal and bacterial keratitis. Thirteen of 37 eyes (35%) were diagnosed with bacterial keratitis. Overall, 26 of 72 total eyes were treated with medical therapy alone (36%). Forty\u2010six of 72 eyes were treated medically and surgically (64%). Of the 26 eyes which received medical therapy, 20 healed with a positive visual outcome (77%) and 6 eyes were non\u2010visual (23%). Of the 46 eyes which received surgical intervention, 40 healed with a positive visual outcome (87%), while six eyes were non\u2010visual (13%). Altogether, 60 of 72 eyes healed with a positive visual outcome following medical or surgical treatment of furrow\u2010forming ulcerative keratitis (83%). Twelve of 72 eyes failed treatment (17%), with six eyes requiring enucleation and six globes becoming phthisical after treatment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main limitations<\/jats:title>\n                    <jats:p>Inconsistencies in available medical record data due to the large span of time (1987\u20132015) are inherent in this retrospective study, along with gradual evolution of corneal surgical techniques and medical therapies over the decades.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Furrow\u2010forming ulcerative keratitis was associated with a positive visual outcome in 83% of horses treated at the University of Florida between the years 1987 and 2015. Furrow formation may be associated with either fungal or bacterial infection.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/evj.13101","type":"journal-article","created":{"date-parts":[[2019,3,19]],"date-time":"2019-03-19T01:08:23Z","timestamp":1552957703000},"page":"749-755","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Equine ulcerative keratitis with furrow: A review of the outcomes of 72 cases from 1987 to 2015"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9291-8027","authenticated-orcid":false,"suffix":"Jr","given":"W. M.","family":"Berkowski","sequence":"first","affiliation":[{"name":"Comparative Ophthalmology Department of Large Animal Clinical Sciences College of Veterinary Medicine University of Florida Gainesville Florida USA"},{"name":"Department of Small Animal Clinical Sciences College of Veterinary Medicine University of Florida Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. F.","family":"Craft","sequence":"additional","affiliation":[{"name":"Department of Anatomic Pathology College of Veterinary Medicine University of Florida Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. 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E.","family":"Plummer","sequence":"additional","affiliation":[{"name":"Comparative Ophthalmology Department of Large Animal Clinical Sciences College of Veterinary Medicine University of Florida Gainesville Florida USA"},{"name":"Department of Small Animal Clinical Sciences College of Veterinary Medicine University of Florida Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,4,5]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.2746\/095777309X409929"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ctep.2005.03.008"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-5224.2012.01031.x"},{"key":"e_1_2_11_5_1","volume-title":"Diseases of the Cornea and Sclera","author":"Andrew S.E.","year":"2017"},{"key":"e_1_2_11_6_1","doi-asserted-by":"crossref","first-page":"105","DOI":"10.2460\/javma.1998.213.01.105","article-title":"Clinical appearances, healing patterns, risk factors, and outcomes of horses with fungal keratitis: 53 cases (1978\u20101996)","volume":"213","author":"Gaarder J.E.","year":"1998","journal-title":"J. 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