{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T05:50:47Z","timestamp":1791697847899,"version":"4.3.4"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,4,5]],"date-time":"2019-04-05T00:00:00Z","timestamp":1554422400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["beva.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Equine Veterinary Journal"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      There is little evidence that horses with equine metabolic syndrome (\n                      <jats:styled-content style=\"fixed-case\">EMS<\/jats:styled-content>\n                      ) have higher resting blood pressures than horses with normal insulin sensitivity. However, there are indications that\n                      <jats:styled-content style=\"fixed-case\">EMS<\/jats:styled-content>\n                      horses have an altered dynamic response to the cardiovascular effects of insulin.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      To examine heart rate and the systemic blood pressure response in\n                      <jats:styled-content style=\"fixed-case\">EMS<\/jats:styled-content>\n                      and control horses during insulin infusion.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study design<\/jats:title>\n                    <jats:p>Cross\u2010sectional study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Horses were examined with an oral sugar test (\n                      <jats:styled-content style=\"fixed-case\">OST<\/jats:styled-content>\n                      ) and a euglycaemic hyperinsulinaemic clamp (\n                      <jats:styled-content style=\"fixed-case\">EHC<\/jats:styled-content>\n                      ). Based on the results from the\n                      <jats:styled-content style=\"fixed-case\">OST<\/jats:styled-content>\n                      , the horses were classified as either\n                      <jats:styled-content style=\"fixed-case\">EMS<\/jats:styled-content>\n                      or control. Blood pressure was measured before the start of the\n                      <jats:styled-content style=\"fixed-case\">EHC<\/jats:styled-content>\n                      and at 60, 120 and 180\u00a0min of the\n                      <jats:styled-content style=\"fixed-case\">EHC<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      There were 16\n                      <jats:styled-content style=\"fixed-case\">EMS<\/jats:styled-content>\n                      and 12 control horses. Mean resting heart rate was higher for\n                      <jats:styled-content style=\"fixed-case\">EMS<\/jats:styled-content>\n                      horses compared with control (35.6\u00a0\u00b1\u00a05.1 vs. 30.3\u00a0\u00b1\u00a03.5\u00a0beats\/min). Systolic, diastolic and mean arterial blood pressure did not differ between groups at the start of the\n                      <jats:styled-content style=\"fixed-case\">EHC<\/jats:styled-content>\n                      . Blood pressure decreased gradually during the\n                      <jats:styled-content style=\"fixed-case\">EHC<\/jats:styled-content>\n                      in the control group, whereas the\n                      <jats:styled-content style=\"fixed-case\">EMS<\/jats:styled-content>\n                      group showed no decline in systolic, diastolic or mean arterial pressure.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main limitations<\/jats:title>\n                    <jats:p>Limited number of horses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Horses with\n                      <jats:styled-content style=\"fixed-case\">EMS<\/jats:styled-content>\n                      have cardiovascular changes that affect resting heart rate and systemic blood pressure during insulin infusion.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/evj.13110","type":"journal-article","created":{"date-parts":[[2019,3,19]],"date-time":"2019-03-19T19:57:53Z","timestamp":1553025473000},"page":"733-737","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["The effect of insulin infusion on heart rate and systemic blood pressure in horses with equine metabolic syndrome"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3306-8397","authenticated-orcid":false,"given":"K.","family":"Nostell","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences Swedish University of Agricultural Sciences (SLU) Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6124-4015","authenticated-orcid":false,"given":"S.","family":"Lind\u00e5se","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Swedish University of Agricultural Sciences (SLU) Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Edberg","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Swedish University of Agricultural Sciences (SLU) Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Br\u00f6jer","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Swedish University of Agricultural Sciences (SLU) Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,4,5]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0163815"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.250.9.1027"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118871"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.101.13.1539"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2007-0006"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1210\/me.2005-0266"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI107996"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118709"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI7535"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI115260"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI114644"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.32.2.243"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.30.5.1144"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13028-016-0247-y"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3306.1983.tb01826.x"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2008.02.029"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13028-016-0246-z"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00580-011-1284-6"},{"key":"e_1_2_11_20_1","first-page":"2183","article-title":"Evaluation of an oral sugar test to diagnose insulin dysregulation in horses","volume":"33","author":"Lind\u00e5se S.","year":"2018","journal-title":"J Vet Intern. 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