{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:49:46Z","timestamp":1787014186811,"version":"build-2736575974"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,5,30]],"date-time":"2019-05-30T00:00:00Z","timestamp":1559174400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100010443","name":"University of Illinois","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010443","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["beva.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Equine Veterinary Journal"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>A recent study demonstrated that enrofloxacin and ciprofloxacin cross the equine placenta without causing gross cartilage or tendon lesions in the 9\u2010month fetus; however, long\u2010term effects of in utero fluoroquinolone exposure remain unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To assess effects of fetal exposure to enrofloxacin on the resulting foal's cartilage and tendon strength.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study design and methods<\/jats:title>\n                    <jats:p>\n                      Healthy mares at 280\u00a0days\u2019 gestation were allocated into four groups: untreated (n\u00a0=\u00a05), therapeutic treatment (7.5\u00a0mg\/kg enrofloxacin,\n                      <jats:styled-content style=\"fixed-case\">PO<\/jats:styled-content>\n                      \u00a0\u00d7\u00a014\u00a0days, n\u00a0=\u00a06), supratherapeutic treatment (15\u00a0mg\/kg,\n                      <jats:styled-content style=\"fixed-case\">PO<\/jats:styled-content>\n                      \u00a0\u00d7\u00a014\u00a0days, n\u00a0=\u00a06) and no mare treatment with treatment of the foals post\u2010partum (n\u00a0=\u00a02). Mares were allowed to carry pregnancy to term, and foals were maintained on pasture for 5\u00a0weeks. After that foals were euthanized, and their articular cartilage and extensor and flexor tendons were examined macroscopically and histologically for lesions. Tendon strength was tested by loading until failure.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Administration of enrofloxacin at recommended doses in late gestation did not result in cartilaginous lesions or clinical lameness in any foal by 5\u00a0weeks old. Tensile strength was greater in hind tendons than front tendons, but no difference was found between foals born from treated and control mares. Expectedly, osteochondral changes were present both in foals born from enrofloxacin\u2010treated mares and in negative control foals with no apparent association with fluoroquinolone treatment during pregnancy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main limitations<\/jats:title>\n                    <jats:p>Only one time point in gestation was evaluated, and mares treated in the study were healthy at time of treatment. Additionally, it is possible that the assessments performed herein were not sensitive enough to detect subtle or functional changes in the articular cartilage. Further studies are needed to determine if enrofloxacin administration during late pregnancy potentiates osteochondral alterations in the first year of life.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>While this study did not assess other stages of gestation or long\u2010term foal outcomes, short\u2010term administration of enrofloxacin to late gestation mares did not result in macroscopic or microscopic lesions in the resulting foals by 5\u00a0weeks of age.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/evj.13131","type":"journal-article","created":{"date-parts":[[2019,4,22]],"date-time":"2019-04-22T10:05:30Z","timestamp":1555927530000},"page":"136-143","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Administration of enrofloxacin during late pregnancy failed to induce lesions in the resulting newborn foals"],"prefix":"10.1111","volume":"52","author":[{"given":"R. E.","family":"Ellerbrock","sequence":"first","affiliation":[{"name":"Department of Veterinary Clinical Medicine University of Illinois Urbana\u2010Champaign Urbana Illinois USA"},{"name":"Department of Comparative Biosciences University of Illinois Urbana\u2010Champaign Urbana Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3799-6641","authenticated-orcid":false,"given":"I. F.","family":"Canisso","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Medicine University of Illinois Urbana\u2010Champaign Urbana Illinois USA"},{"name":"Department of Comparative Biosciences University of Illinois Urbana\u2010Champaign Urbana Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. J.","family":"Roady","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Medicine University of Illinois Urbana\u2010Champaign Urbana Illinois USA"},{"name":"Veterinary Diagnostic Laboratory College of Veterinary Medicine University of Illinois Urbana\u2010Champaign Urbana Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Litsky","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics College of Medicine Ohio State University Columbus Ohio USA"},{"name":"Department of Biomedical Engineering College of Engineering Ohio State University Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Durgam","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences College of Veterinary Medicine Ohio State University Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Podico","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Medicine University of Illinois Urbana\u2010Champaign Urbana Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.","family":"Li","sequence":"additional","affiliation":[{"name":"Roy J. Carver Biotechnology Center University of Illinois Urbana\u2010Champaign Urbana Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.\u00a0S.","family":"Lima","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Medicine University of Illinois Urbana\u2010Champaign Urbana Illinois USA"},{"name":"Department of Comparative Biosciences University of Illinois Urbana\u2010Champaign Urbana Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,5,30]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781118675014.ch18"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2000.217.1514"},{"key":"e_1_2_11_4_1","first-page":"376","article-title":"Quinolone\u2010induced arthropathy in neonatal foals","volume":"47","author":"Vivrette S.","year":"2001","journal-title":"AAEP Proc."},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/evj.13044"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2007.01.077"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cps.2005.05.004"},{"key":"e_1_2_11_8_1","first-page":"466","article-title":"Pharmacokinetics of enrofloxacin and its active metabolite (ciprofloxacin) in late\u2010term pregnant and post\u2010parturient mares","volume":"9","author":"Curcio B.","year":"2017","journal-title":"Clin. 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