{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T03:59:04Z","timestamp":1777348744806,"version":"3.51.4"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,9,23]],"date-time":"2019-09-23T00:00:00Z","timestamp":1569196800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["beva.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Equine Veterinary Journal"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Dynamic laryngeal collapse (DLC) associated with poll flexion is the most common disorder of the upper respiratory tract (URT) in the Norwegian\u2010Swedish Coldblooded Trotter (NSCT). The disorder, which has also been diagnosed in other breeds of trotters and gaited horses, appears to be related to anatomic phenotypes and only occurs during poll flexion when the horse is exercised \u2018on the bit\u2019.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Identify genomic regions associated with DLC in the NSCT by combining a rigorous phenotyping protocol with genomic data from a high\u2010density equine genotyping array.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study design<\/jats:title>\n                    <jats:p>Prospective case\/control study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      High\u2010speed treadmill endoscopy was used to phenotype horses (n\u00a0=\u00a061) for DLC, distinguishing between cases and controls. Genome\u2010wide association (GWA) analysis of DLC status was then performed using a principal component approach (PCA) with haplotype analyses subsequently performed for regions containing single\u2010nucleotide polymorphisms (SNPs) above the suggestive genome\u2010wide significance (GWS) threshold (P&lt;1.0\u00a0\u00d7\u00a010\n                      <jats:sup>\u22125<\/jats:sup>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      One region containing 10 SNPs (\n                      <jats:italic>Equus caballus<\/jats:italic>\n                      chromosome [ECA] 7: 89,601,935\u201394,647,192) was above the suggestive GWS threshold. Two inferred haplotypes in this region demonstrated significant differences (P&lt;0.001) between cases and controls, with the most frequent haplotype resulting in a significantly increased risk of DLC.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main limitations<\/jats:title>\n                    <jats:p>Small sample size as a result of stringent phenotyping protocols.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The current study highlights a candidate genomic region on ECA7 as potentially important with regard to the manifestation of DLC. Further exploration of this region and the genes included within it will bring veterinarians and researchers closer to fully understanding the biological mechanisms underlying DLC in horses.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/evj.13171","type":"journal-article","created":{"date-parts":[[2019,8,28]],"date-time":"2019-08-28T18:22:34Z","timestamp":1567016554000},"page":"174-180","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Exploring the genetics underpinning dynamic laryngeal collapse associated with poll flexion in Norwegian\u2010Swedish Coldblooded Trotter racehorses"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9359-6138","authenticated-orcid":false,"given":"B. D.","family":"Velie","sequence":"first","affiliation":[{"name":"Faculty of Science School of Life and Environmental Sciences University of Sydney Sydney Australia"},{"name":"Department of Animal Breeding and Genetics Swedish University of Agricultural Sciences Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. M.","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Companion Animal Clinical Sciences Norwegian University of Life Sciences Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. T.","family":"Fjordbakk","sequence":"additional","affiliation":[{"name":"Department of Companion Animal Clinical Sciences Norwegian University of Life Sciences Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Sol\u00e9","sequence":"additional","affiliation":[{"name":"Department of Animal Breeding and Genetics Swedish University of Agricultural Sciences Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"J\u00e4derkvist Fegraeus","sequence":"additional","affiliation":[{"name":"Department of Animal Breeding and Genetics Swedish University of Agricultural Sciences Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. K.","family":"Rosengren","sequence":"additional","affiliation":[{"name":"Department of Animal Breeding and Genetics Swedish University of Agricultural Sciences Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. H.","family":"R\u00f8ed","sequence":"additional","affiliation":[{"name":"Department of Basic Sciences and Aquatic Medicine Norwegian University of Life Sciences Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. F.","family":"Ihler","sequence":"additional","affiliation":[{"name":"Department of Companion Animal Clinical Sciences Norwegian University of Life Sciences Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Lindgren","sequence":"additional","affiliation":[{"name":"Department of Animal Breeding and Genetics Swedish University of Agricultural Sciences Uppsala Sweden"},{"name":"Livestock Genetics Department of Biosystems KU Leuven Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Strand","sequence":"additional","affiliation":[{"name":"Department of Companion Animal Clinical Sciences Norwegian University of Life Sciences Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,9,23]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3292.2004.tb00306.x"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3306.2011.00517.x"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.21836\/PEM20100607"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cveq.2014.11.009"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.2746\/042516408X330392"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3306.2011.00516.x"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/evj.12066"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-950X.2008.00396.x"},{"key":"e_1_2_13_10_1","volume-title":"R: A Language and Environment for Statistical Computing","author":"Development Core Team R.","year":"2015"},{"key":"e_1_2_13_11_1","volume-title":"A Handbook of Statistical Analyses Using R","author":"Everitt B.S.","year":"2010"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bth457"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1086\/338688"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000071811"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.772403"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv1194"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyr178"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1152\/physiolgenomics.00068.2018"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-15-259"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00335-011-9337-3"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/evj.12357"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11399"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/age.12120"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/age.12610"},{"key":"e_1_2_13_25_1","first-page":"734","article-title":"Different DMRT3 genotypes are best adapted for harness racing and riding in Finnhorses","volume":"106","author":"J\u00e4derkvist Fegraeus K.","year":"2015","journal-title":"J. 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