{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T00:11:22Z","timestamp":1771632682980,"version":"3.50.1"},"reference-count":14,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,9,23]],"date-time":"2019-09-23T00:00:00Z","timestamp":1569196800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000691","name":"Academy of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["beva.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Equine Veterinary Journal"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Early results from the use of neuromodulation by percutaneous electrical nerve stimulation for the management of trigeminal\u2010mediated headshaking in horses were promising but lacked sufficient case numbers and long\u2010term follow\u2010up. The neuromodulatory procedure has since been established as EquiPENS\u2122.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The aim of this study was to report long\u2010term results from a larger number of cases and to investigate for predictors of outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study design<\/jats:title>\n                    <jats:p>Prospective case series using international, multi\u2010centre data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Eligible cases were horses with a veterinary diagnosis of trigeminal\u2010mediated headshaking, which received EquiPENS\u2122 neuromodulation at trained centres between August 2013 and November 2017. The standard protocol was an initial three\u2010procedure course, with additional procedures should a horse go into remission but then relapse. Data collected included signalment, history, diagnostic tests performed, details of any complications, whether horses had gone into remission and the length of remission.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Results were obtained from 168 horses, with 530 procedures. The complication rate was 8.8% of procedures. In all but one case, complications were mild and transient, without self\u2010trauma. Remission of headshaking following the initial course occurred in 53% (72\/136) of horses. Median length of time recorded in remission was 9.5\u00a0weeks (range 2\u00a0days to 156\u00a0weeks ongoing). Where signs recurred, most horses went back into remission following additional procedures, usually for longer than from the previous procedure. No predictors for outcome were determined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main limitations<\/jats:title>\n                    <jats:p>No placebo or control group, owner\u2010assessed results.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>EquiPENS\u2122 neuromodulation can be an effective and safe treatment for the management of trigeminal\u2010mediated headshaking in some horses. An increased understanding of neuromodulation could help optimise the technique. Advances in treatment for trigeminal\u2010mediated headshaking will remain limited until there is a greater understanding of the aetiopathogenesis of the condition.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/evj.13174","type":"journal-article","created":{"date-parts":[[2019,8,28]],"date-time":"2019-08-28T18:43:59Z","timestamp":1567017839000},"page":"238-243","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["The safety and efficacy of neuromodulation using percutaneous electrical nerve stimulation for the management of trigeminal\u2010mediated headshaking in 168 horses"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5354-7160","authenticated-orcid":false,"given":"V. L. H.","family":"Roberts","sequence":"first","affiliation":[{"name":"Bristol Veterinary School University of Bristol Somerset UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Bailey","sequence":"additional","affiliation":[{"name":"Bristol Veterinary School University of Bristol Somerset UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"The Equipens\u2122 group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. K.","family":"Patel","sequence":"additional","affiliation":[{"name":"Institute of Neurosciences Southmead Hospital Bristol Westbury\u2010on\u2010Trym, Bristol UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,9,23]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2014.03.031"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.2746\/042516400776563617"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2001.219.334"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3306.1999.tb03184.x"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3306.2012.00553.x"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.152.2.41"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3306.1998.tb05141.x"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.12191"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2017.00072"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/evj.12394"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/eve.12776"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.c5992"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3306.2012.00618.x"},{"key":"e_1_2_12_15_1","unstructured":"Neuropathic pain in adults: pharmacological management in non\u2010specialist settings Clinical guideline [CG173]Published date: November 2013 Last updated: April 2018. Available at:https:\/\/www.nice.org.uk\/guidance\/cg173\/chapter\/1-Recommendations."}],"container-title":["Equine Veterinary Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fevj.13174","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/evj.13174","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/evj.13174","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/beva.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/evj.13174","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T13:13:13Z","timestamp":1762089193000},"score":1,"resource":{"primary":{"URL":"https:\/\/beva.onlinelibrary.wiley.com\/doi\/10.1111\/evj.13174"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,23]]},"references-count":14,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["10.1111\/evj.13174"],"URL":"https:\/\/doi.org\/10.1111\/evj.13174","archive":["Portico"],"relation":{},"ISSN":["0425-1644","2042-3306"],"issn-type":[{"value":"0425-1644","type":"print"},{"value":"2042-3306","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,23]]},"assertion":[{"value":"2018-09-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-07-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}