{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:49:46Z","timestamp":1787014186883,"version":"build-2736575974"},"reference-count":44,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,8,18]],"date-time":"2020-08-18T00:00:00Z","timestamp":1597708800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["beva.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Equine Veterinary Journal"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Phenylbutazone is commonly prescribed for treatment of various painful or inflammatory disorders in horses, but is associated with gastrointestinal (GI) adverse effects. Anecdotally, many practitioners prescribe omeprazole concurrently with phenylbutazone to reduce development of equine gastric ulcer syndrome (EGUS), but the efficacy and safety of this practice remains unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate the effect of omeprazole on phenylbutazone\u2010induced equine glandular gastric disease (EGGD) and equine squamous gastric disease (ESGD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study design<\/jats:title>\n                    <jats:p>Randomised block experimental design.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Twenty\u2010two horses with EGGD and ESGD scores \u22642 were included. Horses were assigned to treatment groups: phenylbutazone (4.4\u00a0mg\/kg PO q 12 h; PBZ), phenylbutazone plus omeprazole (4\u00a0mg\/kg PO q. 24 h; PBZ\/OME) or placebo (CON) in a randomised block design based upon initial EGGD score. Horses were treated for up to 14\u00a0days. Gastroscopy was performed weekly; CBC and biochemistry were performed at Day 0 and study end. Horses were monitored for signs of colic and\/or diarrhoea.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      EGGD score increased in PBZ (median change 1, inter\u2010quartile range, [IQR], 0\u20102) compared to PBZ\/OME (median change 0, IQR \u22121 to 0;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.05). PBZ\/OME (6\/8) had more intestinal complications than CON (0\/6; difference between proportions\u00a0=\u00a075%; 95% CI, 23%\u201093%;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.03). Plasma protein concentrations decreased in PBZ, compared to CON (mean difference between groups, 14\u00a0g\/L; 95% CI, 1.04\u201027;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.03). Five horses were withdrawn from the study due to intestinal complications (n\u00a0=\u00a03 PBZ\/OME and n\u00a0=\u00a02 PBZ); one horse (PBZ) was withdrawn due to severe grade 4 EGGD.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main limitations<\/jats:title>\n                    <jats:p>Small sample size and changes in management for the 2\u20103\u00a0days prior to study initiation; variable treatment duration among groups due to development of complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Administration of omeprazole ameliorated PBZ\u2010induced EGGD, but was associated with an increase in intestinal complications. Caution should be exercised when co\u2010prescribing NSAIDs and omeprazole in horses, particularly in association with change in management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/evj.13323","type":"journal-article","created":{"date-parts":[[2020,7,22]],"date-time":"2020-07-22T16:31:30Z","timestamp":1595435490000},"page":"356-363","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Impact of concurrent treatment with omeprazole on phenylbutazone\u2010induced equine gastric ulcer syndrome (EGUS)"],"prefix":"10.1111","volume":"53","author":[{"given":"Megan","family":"Ricord","sequence":"first","affiliation":[{"name":"Equine Health Studies Program Department of Veterinary Clinical Sciences School of Veterinary Medicine Louisiana State University Baton Rouge LA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7930-6237","authenticated-orcid":false,"given":"Frank M.","family":"Andrews","sequence":"additional","affiliation":[{"name":"Equine Health Studies Program Department of Veterinary Clinical Sciences School of Veterinary Medicine Louisiana State University Baton Rouge LA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco J. 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