{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T02:35:06Z","timestamp":1790217306072,"version":"4.1.0"},"reference-count":46,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,7,4]],"date-time":"2021-07-04T00:00:00Z","timestamp":1625356800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["beva.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Equine Veterinary Journal"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Equine parvovirus hepatitis (EqPV\u2010H) was first described in 2018 in a fatal case of Theiler's disease which followed the administration of an equine\u2010origin biological product. The virus has since been frequently identified in serum and liver tissue of horses affected by Theiler's disease\u2014an acute, severe hepatitis characterised by fulminant hepatic necrosis with a fatal outcome in most cases. EqPV\u2010H is hepatotropic, appears to be associated with subclinical to severe hepatitis in horses, and is a likely cause of Theiler's disease. Although this disease is most frequently reported following the administration of equine\u2010origin biological products, it can also occur among in\u2010contact horses. Horizontal transmission may be iatrogenic, via contaminated equine\u2010origin biological products such as equine serum, botulism or tetanus antitoxin, and mesenchymal stem cells or by means of the oral route of infection. Other horizontal transmission routes, for example, arthropod vectors, warrant further investigation. A worldwide prevalence of EqPV\u2010H antibodies and DNA has been reported in asymptomatic horses. EqPV\u2010H\u2010positive horses suffering from acute, severe hepatitis have reportedly developed clinical signs including icterus, lethargy, inappetence, and neurological abnormalities and have had increased liver\u2010associated biochemistry parameters recorded. The most common histopathological abnormalities of the liver have been hepatocellular necrosis, collapse of the lobular architecture, and lymphocytic infiltration. Most horses infected experimentally with EqPV\u2010H have developed subclinical hepatitis, and close temporal associations between peak viraemia, seroconversion, and the onset of hepatitis have been observed. Based on strong evidence indicating that EqPV\u2010H causes hepatitis in horses, veterinarians should consider this virus an important differential diagnosis in such cases. Potential risks associated with the administration of equine\u2010origin biological products must be emphasised.<\/jats:p>","DOI":"10.1111\/evj.13477","type":"journal-article","created":{"date-parts":[[2021,6,8]],"date-time":"2021-06-08T21:11:03Z","timestamp":1623186663000},"page":"886-894","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Equine parvovirus hepatitis"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4741-3972","authenticated-orcid":false,"given":"Anna Sophie","family":"Ramsauer","sequence":"first","affiliation":[{"name":"Department for Companion Animals and Horses University Equine Clinic \u2013 Internal Medicine University of Veterinary Medicine Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5732-1281","authenticated-orcid":false,"given":"Marcha","family":"Badenhorst","sequence":"additional","affiliation":[{"name":"Department for Companion Animals and Horses University Equine Clinic \u2013 Internal Medicine University of Veterinary Medicine Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8575-7402","authenticated-orcid":false,"given":"Jessika\u2010M. V.","family":"Cavalleri","sequence":"additional","affiliation":[{"name":"Department for Companion Animals and Horses University Equine Clinic \u2013 Internal Medicine University of Veterinary Medicine Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,7,4]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-1-4557-4555-5.00066-2"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cveq.2019.03.001"},{"key":"e_1_2_12_4_1","unstructured":"TheilerAAcute Liver\u2010Atrophy and Parenchymatous Hepatitis in Horses Union of South Africa. Dept. of Agriculture. 5th and 6th Repts. of the Director of Veterinary Research. p.7\u2013164."},{"key":"e_1_2_12_5_1","first-page":"88","article-title":"Losses of undetermined cause following an outbreak of equine encephalomyelitis","volume":"91","author":"Marsh H","year":"1937","journal-title":"J Am Vet Med Assoc"},{"key":"e_1_2_12_6_1","first-page":"734","article-title":"Serum hepatitis in the horse","volume":"144","author":"Hjerpe C","year":"1964","journal-title":"J Am Vet Med Assoc"},{"key":"e_1_2_12_7_1","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.2460\/javma.1994.204.11.1790","article-title":"Serum hepatitis in two brood mares","volume":"204","author":"Johnson P","year":"1994","journal-title":"J Am Vet Med Assoc"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3306.1971.tb04433.x"},{"key":"e_1_2_12_9_1","first-page":"13","article-title":"Penicillin\u2010induced hemolytic anemia and acute hepatic failure following treatment of tetanus in 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