{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T02:33:33Z","timestamp":1778121213991,"version":"3.51.4"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,7,27]],"date-time":"2021-07-27T00:00:00Z","timestamp":1627344000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["beva.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Equine Veterinary Journal"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The aetiology of equine medial femoral condyle (MFC) subchondral bone radiolucencies (SR) is unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Characterise the microstructural structural features of MFC SR in juvenile Thoroughbreds with microcomputed tomography (\u03bcCT) and histology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study design<\/jats:title>\n                    <jats:p>Cross\u2010sectional post\u2010mortem study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Distal femurs were collected at post\u2010mortem. Conventional tomodensitometry was employed to scout for MFCs with and without SR lesions (SR+ and SR\u2212, respectively). Group 1 were CT MFC SR+ and Group 2 age\u2010matched SR\u2212 controls. Both underwent \u03bcCT and histological analysis. Group 3 CT MFC SR\u2212 foals, &lt;6\u00a0months, were selected to search for chondronecrosis. Histological sections, processed from the lesion (Group 1) and a corresponding site in Groups 2 and 3, were assessed for chondronecrosis, fibrin, fibroplasia and osteochondral separation. Group 3 sections were surveyed for chondronecrosis alone.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 178 femurs from 89 Thoroughbreds were harvested. Of these horses 19.1% (95% CI: 10.9%\u201027.3%) were CT MFC SR+ (17\/23; 7.46\u00a0\u00b1\u00a04.36\u00a0months) and met the inclusion criteria for Group 1. Group 2 included 30 CT MFC SR\u2212 specimens (5.00\u00a0\u00b1\u00a02.73\u00a0months) and Group 3 had 44 CT MFC SR\u2212 s (2.68\u00a0\u00b1\u00a01.74\u00a0months). SR were located axially in foals &lt;7\u00a0months of age, and centrally thereafter. All SRs had areas of thickened cartilage on histology and separation at the osteochondral junction containing fibrin (acute event) and fibroplasia (chronicity) in 73.9% (17\/23; 95% CI: 56%\u201091.9%). In Group 1 specimens, chondronecrosis was present in 82.6% (19\/23; 95% CI: 67.1%\u201098.1%) but four MFC SR+ had no evidence of chondronecrosis. Chondronecrosis was not detected in the Group 3 foal MFCs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main limitations<\/jats:title>\n                    <jats:p>No longitudinal follow\u2010up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The absence of chondronecrosis, pathognomic of osteochondrosis, in four MFC SR+s and in all of the CT MFC SR\u2212 foals suggests that osteochondrosis is not the cause, or the only cause, of these lesions and favours trauma as an alternate aetiological hypothesis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/evj.13486","type":"journal-article","created":{"date-parts":[[2021,6,12]],"date-time":"2021-06-12T03:49:47Z","timestamp":1623469787000},"page":"601-613","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Microstructural features of subchondral radiolucent lesions in the medial femoral condyle of juvenile Thoroughbreds: A microcomputed tomography and histological analysis"],"prefix":"10.1111","volume":"54","author":[{"given":"Thibeaut","family":"Lemirre","sequence":"first","affiliation":[{"name":"Comparative Orthopaedic Research Laboratory D\u00e9partement de Sciences Cliniques Facult\u00e9 de M\u00e9decine V\u00e9t\u00e9rinaire Universit\u00e9 de Montr\u00e9al  St\u2010Hyacinthe QC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6864-4302","authenticated-orcid":false,"given":"Elizabeth M.","family":"Santschi","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine Kansas State University  Manhattan KS USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christiane A.","family":"Girard","sequence":"additional","affiliation":[{"name":"Comparative Orthopaedic Research Laboratory D\u00e9partement de Sciences Cliniques Facult\u00e9 de M\u00e9decine V\u00e9t\u00e9rinaire Universit\u00e9 de Montr\u00e9al  St\u2010Hyacinthe QC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ursula","family":"Fogarty","sequence":"additional","affiliation":[{"name":"Irish Equine Centre  Johnstown Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer G.","family":"Janes","sequence":"additional","affiliation":[{"name":"Department of Veterinary Science University of Kentucky  Lexington KY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0892-5799","authenticated-orcid":false,"given":"Helene","family":"Richard","sequence":"additional","affiliation":[{"name":"Comparative Orthopaedic Research Laboratory D\u00e9partement de Sciences Cliniques Facult\u00e9 de M\u00e9decine V\u00e9t\u00e9rinaire Universit\u00e9 de Montr\u00e9al  St\u2010Hyacinthe QC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3300-6620","authenticated-orcid":false,"given":"Sheila","family":"Laverty","sequence":"additional","affiliation":[{"name":"Comparative Orthopaedic Research Laboratory D\u00e9partement de Sciences Cliniques Facult\u00e9 de M\u00e9decine V\u00e9t\u00e9rinaire Universit\u00e9 de Montr\u00e9al  St\u2010Hyacinthe QC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,7,27]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300985815588778"},{"key":"e_1_2_13_3_1","first-page":"153","article-title":"Osteochondrosis in the horse. 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