{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T21:36:30Z","timestamp":1792704990869,"version":"4.5.0"},"reference-count":58,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,11,19]],"date-time":"2021-11-19T00:00:00Z","timestamp":1637280000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["beva.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Equine Veterinary Journal"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>A 10\u2010year\u2010old 466\u00a0kg mustang gelding presented to an equine referral hospital for surgical repair of nasal, frontal and lacrimal bone fractures from an unknown trauma. Surgical repair was performed under general anaesthesia, including a right\u2010sided maxillary regional anaesthetic block with mepivacaine hydrochloride. Progressive hyperkalaemia was documented perianaesthetically (T\u20103\u00a0mins; 134\u00a0mins after induction; potassium 6.4\u00a0mmol\/L (ref 3.5\u20105.1\u00a0mmol\/L). Perianaesthetic bradycardia was attributed to alpha \u22122 agonist infusion administration, and other characteristic ECG changes (flattened P waves, narrow T waves of increased amplitude, prolonged QRS complex) were not documented. Asystole occurred 137\u00a0min after induction of anaesthesia; however, a review of the available literature suggests the degree of hyperkalaemia documented was unlikely to be the primary cause of asystole but may have been a contributing factor. It is hypothesised that a trigeminocardiac reflex was the primary contributory factor to asystole in the described case, and may represent a maxillomandibulocardiac reflex that has not been previously described in the horse.<\/jats:p>","DOI":"10.1111\/evj.13535","type":"journal-article","created":{"date-parts":[[2021,11,5]],"date-time":"2021-11-05T02:15:31Z","timestamp":1636078531000},"page":"927-933","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Suspected vagal reflex and\u00a0hyperkalaemia\u00a0inducing asystole in an anaesthetised horse"],"prefix":"10.1111","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1134-7638","authenticated-orcid":false,"given":"Aoife","family":"Ryan","sequence":"first","affiliation":[{"name":"University of Veterinary Medicine  Vienna Austria"},{"name":"Anderson Moores Veterinary Specialists  Winchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Gurney","sequence":"additional","affiliation":[{"name":"Anderson Moores Veterinary Specialists  Winchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roswitha","family":"Steinbacher","sequence":"additional","affiliation":[{"name":"University of Veterinary Medicine  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,11,19]]},"reference":[{"issue":"7","key":"e_1_2_12_2_1","doi-asserted-by":"crossref","first-page":"630","DOI":"10.2460\/javma.1980.176.07.630","article-title":"Complications caused by the oculocardiac reflex during anaesthesia in a foal","volume":"176","author":"Short CE","year":"1980","journal-title":"J Am Vet"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.2746\/042516400777584659"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2018.10.186"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13028\u2010018\u20100421\u20105"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.res.17.1.39"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplegacy.1944.142.4.627"},{"key":"e_1_2_12_8_1","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1002\/9780470753248.ch18","volume-title":"Manual of Equine anaesthesia and analgesia","author":"Schumacher J","year":"2006"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12663\u2010016\u20100959\u20106"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-800421-0.00005-9"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/ANA.0000000000000065"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1201\/9783842683686"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000000484"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/ANA.0000000000000065"},{"key":"e_1_2_12_15_1","first-page":"1529","article-title":"Ueber einen bisher noch nicht heschriebenen reflex vom auge auf kreislauf und atmung: Verschwinden des Radialispulses bei Druck auf das Auge","volume":"21","author":"Aschner B","year":"1908","journal-title":"Wien Klin Wochenscr"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/vop.12077"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030\u20104220(87)90110\u20101"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplegacy.1929.88.4.581"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/eve.12001"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/vsu.12469"},{"key":"e_1_2_12_21_1","first-page":"703","article-title":"Determination of the acid\u2010base status in 50 horses admitted with colic between December 1998 and May 1999","volume":"42","author":"Nappert G","year":"2018","journal-title":"Can Vet J"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.emc.2005.03.016"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-1-4377-0654-3.00012-3"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/inp.i1849"},{"issue":"11","key":"e_1_2_12_25_1","doi-asserted-by":"crossref","first-page":"934","DOI":"10.2460\/ajvr.1982.43.11.1934","article-title":"Electrocardiographic changes in induced hyperkalaemia in ponies","volume":"43","author":"Glazier DB","year":"1982","journal-title":"Am J Vet Res"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042\u20103306.1984.tb01978.x"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476\u20104431.2007.00268.x"},{"key":"e_1_2_12_28_1","first-page":"27","volume-title":"Equine fluid therapy first edition","author":"Fielding CL"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.239.4.442"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467\u20102995.2010.00592.x"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042\u20103306.1994.tb04061.x"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939\u20101676.2008.0167.x"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/0034\u20105288(93)90104\u2010N"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.144.3.73"},{"key":"e_1_2_12_35_1","unstructured":"SteeilJ RamsayEC SchumacherJ MarinM MosleyC ReillyS SeddighiMR. 2013 Proceedings Annual Conference AAZV. Hyperkalaemia in exotic felids anaesthetized with an alpha\u20102 adrenoceptor agonist ketamine and isoflurane. 2013; 13."},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1136\/vetreccr\u20102018\u2010000755"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1638\/2017\u20100147.1"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/63.6.702"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aat.2015.07.002"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003\u20104819\u201084\u20104\u2010426"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.118.3.65"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.15747"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2013.09.063"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cveq.2012.11.011"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0001-2092(06)62180-7"},{"issue":"2","key":"e_1_2_12_46_1","doi-asserted-by":"crossref","first-page":"365","DOI":"10.2460\/ajvr.1985.46.02.365","article-title":"Hemodynamic responses in halothane\u2010anaesthetized horses given infusions of dopamine or dobutamine\u2019","volume":"46","author":"Swanson CR","year":"1985","journal-title":"Am J Vet Res"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467\u20102995.2006.00304.x"},{"issue":"11","key":"e_1_2_12_48_1","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.2460\/ajvr.1998.59.11.1463","article-title":"Effects of dopamine, dobutamine, dopexamine, phenylephrine, and saline solution on intramuscular blood flow and other cardiopulmonary variables in halothane\u2010anaesthetized ponies","volume":"59","author":"Lee YHL","year":"1998","journal-title":"Am J Veterinary Res"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/9780470753248"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-1-4160-2326-5.00023-7"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781119421375.ch9"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1472\u20108206.1993.tb00228.x"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jemermed.2018.04.004"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939\u20101676.1998.tb02114.x"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11259\u2010010\u20109439\u20105"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.229.7.1134"},{"issue":"2","key":"e_1_2_12_57_1","first-page":"99","article-title":"Effects of high\u2010volume, rapid\u2010fluid therapy on cardiovascular functions and hematological values during isoflurane induced hypotension in healthy dogs","volume":"76","author":"Valverde A","year":"2012","journal-title":"Can J Vet"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.71.7.840"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1080\/08860220802064770"}],"container-title":["Equine Veterinary Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/evj.13535","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/evj.13535","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/beva.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/evj.13535","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T09:02:10Z","timestamp":1762074130000},"score":1,"resource":{"primary":{"URL":"https:\/\/beva.onlinelibrary.wiley.com\/doi\/10.1111\/evj.13535"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,19]]},"references-count":58,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["10.1111\/evj.13535"],"URL":"https:\/\/doi.org\/10.1111\/evj.13535","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/EVJ.13535\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EVJ.13535\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EVJ.13535\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EVJ.13535\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EVJ.13535\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EVJ.13535\/v3\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EVJ.13535\/v3\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EVJ.13535\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EVJ.13535\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EVJ.13535\/v1\/review2","asserted-by":"object"}]},"ISSN":["0425-1644","2042-3306"],"issn-type":[{"value":"0425-1644","type":"print"},{"value":"2042-3306","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,19]]},"assertion":[{"value":"2021-03-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}