{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T08:40:42Z","timestamp":1780562442312,"version":"3.54.1"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,11,19]],"date-time":"2021-11-19T00:00:00Z","timestamp":1637280000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["beva.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Equine Veterinary Journal"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Peritoneal bile acids concentration (PBAC) has not been previously reported in horses. A case of liver lobe torsion in which increased PBAC was detected prompted us to study PBAC in horses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>(a) To determine a reference range of PBAC in horses; (b) to compare PBAC from horses with either hepatic or gastrointestinal disease and healthy horses and (c) to assess the prognostic and diagnostic values of PBAC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study design<\/jats:title>\n                    <jats:p>Prospective case\u2010control.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Prospective observational clinical study. Bile acids concentrations were measured in both plasma and peritoneal fluid in selected clinical patients with hepatic or gastrointestinal disease (n\u00a0=\u00a0108) and healthy horses (n\u00a0=\u00a011). Sixty\u2010eight of 108 patients survived to hospital discharge, and the remaining 40 were nonsurvivors. Additionally, other haematological and biochemistry analyses were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Sick horses were classified according to diagnosis into hepatic (n\u00a0=\u00a013), gastrointestinal (GI) obstructive (n\u00a0=\u00a048) and GI ischaemic\u2010inflammatory (n\u00a0=\u00a047) groups. The hepatic group had significantly higher PBAC (6.8 [2.3\u20109.4]; median [IQR]) than the control (1.0 [0.6\u20101.5]) and GI obstructive groups (1.2 [0.8\u20101.7] \u00b5mol\/L;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.001). Moreover, the GI ischaemic\u2010inflammatory group (3.3 [1.4\u20105.5]) also had significantly higher values than the control and GI obstructive groups (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.001). Regarding outcome, the nonsurvivor group (n\u00a0=\u00a040) had significantly higher median PBAC value than the survivor group (n\u00a0=\u00a068, 4.1 [1.6\u20106.5] vs 1.3 [0.8\u20103];\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main limitations<\/jats:title>\n                    <jats:p>A higher number of horses with abdominal disease is required to confirm the clinical significance of these findings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>PBAC may have a role in the diagnosis of hepatic and gastrointestinal disease and as a prognostic tool in horses with abdominal pain.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/evj.13538","type":"journal-article","created":{"date-parts":[[2021,11,7]],"date-time":"2021-11-07T08:54:32Z","timestamp":1636275272000},"page":"914-921","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Peritoneal bile acids concentration in adult horses with hepatic and gastrointestinal disorders"],"prefix":"10.1111","volume":"54","author":[{"given":"Maria L.","family":"Rodr\u00edguez\u2010Pozo","sequence":"first","affiliation":[{"name":"Servei de Medicina Interna Equina Fundaci\u00f3 Hospital Cl\u00ednic Veterinari Universitat Aut\u00f2noma de Barcelona  Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4715-7323","authenticated-orcid":false,"given":"Lara","family":"Armengou","sequence":"additional","affiliation":[{"name":"Servei de Medicina Interna Equina Fundaci\u00f3 Hospital Cl\u00ednic Veterinari Universitat Aut\u00f2noma de Barcelona  Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5166-4139","authenticated-orcid":false,"given":"Judit","family":"Viu","sequence":"additional","affiliation":[{"name":"Servei de Medicina Interna Equina Fundaci\u00f3 Hospital Cl\u00ednic Veterinari Universitat Aut\u00f2noma de Barcelona  Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0716-8784","authenticated-orcid":false,"given":"Jose","family":"R\u00edos","sequence":"additional","affiliation":[{"name":"Laboratory of Biostatistics and Epidemiology, Statistics and Methodology Support Unit IDIBAPS, Hospital Clinic  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4536-7717","authenticated-orcid":false,"given":"Eduard","family":"Jose\u2010Cunilleras","sequence":"additional","affiliation":[{"name":"Servei de Medicina Interna Equina Fundaci\u00f3 Hospital 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