{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T01:12:07Z","timestamp":1790125927776,"version":"4.0.1"},"reference-count":17,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,8,3]],"date-time":"2022-08-03T00:00:00Z","timestamp":1659484800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100015103","name":"Japan Racing Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015103","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["beva.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Equine Veterinary Journal"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Equine coronavirus (ECoV) causes fever, lethargy, anorexia and gastrointestinal signs in horses. There has been limited information about the prevalence and seasonality of ECoV among Thoroughbreds in Japan.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To understand the epidemiology and to evaluate the potential risk of ECoV infection to the horse industry in Japan.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study design<\/jats:title>\n                    <jats:p>Longitudinal.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The virus\u2010neutralisation (VN) test was performed using sera collected three times a year at 4\u00a0months intervals from 161 yearlings and at 6\u20137\u00a0months intervals from 181 active racehorses in Japan in 2017\u20132018, 2018\u20132019 and 2019\u20132020. VN titre\u2009\u22651:8 was defined as seropositive, and \u22654\u2010fold increase in titres between paired sera was regarded as indicative of infection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The VN test showed that 44.1% (71\/161) of yearlings were seropositive in August, when they first entered the yearling farm. The infection rate was significantly higher between August and December (60.9%, 98\/161) than between December and the following April (5.6%, 9\/161;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.002). Among the racehorses, it was significantly higher between November and the following May (15.5%, 28\/181) than between the preceding April\/May and November (0%;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.02). The morbidity rates during the estimated periods of viral exposure were 39.2% in the yearlings and 4% in the racehorses. No horses showed any severe clinical signs.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main limitations<\/jats:title>\n                    <jats:p>Clinical records did not cover the period during horses' absence from the training centre.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>ECoV was substantially prevalent in Thoroughbred yearlings and racehorses in Japan, and there was a difference in epizootic pattern between these populations in terms of predominant periods of infection. ECoV infection was considered to be responsible for some of the pyretic cases in the yearlings. However, no diseased horses were severely affected in either population, suggesting that the potential risk of ECoV infection to the horse industry in Japan is low.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/evj.13857","type":"journal-article","created":{"date-parts":[[2022,7,13]],"date-time":"2022-07-13T09:28:42Z","timestamp":1657704522000},"page":"481-486","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Serosurveillance of equine coronavirus infection among Thoroughbreds in Japan"],"prefix":"10.1111","volume":"55","author":[{"given":"Yoshinori","family":"Kambayashi","sequence":"first","affiliation":[{"name":"Equine Research Institute, Japan Racing Association  Shimotsuke Tochigi 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