{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T20:34:38Z","timestamp":1785270878959,"version":"3.55.0"},"reference-count":38,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,1,9]],"date-time":"2023-01-09T00:00:00Z","timestamp":1673222400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["beva.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Equine Veterinary Journal"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Liposomal local anaesthetic solutions may provide extended\u2010duration analgesia postoperatively but have not been assessed following intra\u2010peritoneal local infiltration in any species.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate two doses of 1.33% liposomal bupivacaine (LB) versus 0.75% bupivacaine HCL (BHCl) for analgesia following laparoscopic ovariectomy in mares.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study design<\/jats:title>\n                    <jats:p>Prospective cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Fifteen healthy Quarter Horse mares (age 2\u201320\u2009years) with normal bilateral ovarian palpation and appearance were enrolled. Horses were restrained in standing stocks and administered an \u03b1\u20102 agonist, butorphanol, and flunixin meglumine, followed by a variable rate infusion of sedation with \u03b1\u20102 agonists. Bilateral paralumbar fossa ovariectomies were performed. Treatment with either 30\u2009ml 0.75% BHCl followed by 20 or 40\u2009ml LB 13.3% (LB20 and LB40) volume expanded with saline to 80\u2009ml total (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a06\/group) or 80\u2009ml BHCl alone (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a03, BCHL) was infused around incision sites and each mesovarium (LB or BHCl) prior to ovariectomy. Horses were monitored for 72\u2009h by physical examination, algometry, and pain scoring (composite pain scale by Bussieres et al., Horse Grimace Scale). Abdominocentesis with peritoneal fluid analysis was performed at 72\u2009h.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Analgesia achieved with all treatment protocols allowed completion of ovariectomy procedures. Pressure algometry scores were lower in BHCl\u2010treated horses versus both LB groups overall. Pain scores were improved with LB\u2010treated horses in a dose\u2010dependent fashion (Horse Grimace Scale scores LB40\u2009&lt;\u2009LB20\u2009&lt;\u2009BHCL; composite pain scale scores LB40\u2009&lt;\u2009BHCL, LB20\u2009&lt;\u2009BHCL, BHCL, and LB20 did not differ). Peritoneal fluid total protein was lower in LB40 versus LB20 and BHCL horses. No complications from LB administration were appreciated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main limitations<\/jats:title>\n                    <jats:p>Small patient sample size, lack of follow\u2010up past 72\u2009h or histopathology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Analgesia duration was extended and pain scores improved postoperatively with LB versus BHCl in a dose\u2010dependent fashion. Further clinical evaluation of extended\u2010duration local anaesthetics in horses for improved postoperative pain management is warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/evj.13915","type":"journal-article","created":{"date-parts":[[2022,12,26]],"date-time":"2022-12-26T23:16:47Z","timestamp":1672096607000},"page":"755-764","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Liposomal bupivacaine is both safe and effective when administered via local infiltration at surgical site and mesovarium for laparoscopic ovariectomy in mares"],"prefix":"10.1111","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4990-5006","authenticated-orcid":false,"given":"Lynn M.","family":"Pezzanite","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences Colorado State University  Fort Collins Colorado 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