{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T16:41:16Z","timestamp":1789749676966,"version":"4.0.1"},"reference-count":34,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,1,18]],"date-time":"2023-01-18T00:00:00Z","timestamp":1674000000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100011119","name":"College of Veterinary Medicine, University of Georgia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011119","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["beva.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Equine Veterinary Journal"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Donkeys with clinical signs of pituitary pars intermedia dysfunction are treated with oral pergolide mesylate despite the lack of species\u2010specific pharmacokinetic data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      To evaluate the pharmacokinetics of intragastric and oral pergolide mesylate in healthy donkeys (\n                      <jats:italic>Equus asinus<\/jats:italic>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study design<\/jats:title>\n                    <jats:p>Pharmacokinetic study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Six healthy donkeys were administered pergolide mesylate (Prascend\u00ae) at 2\u2009\u03bcg\/kg bodyweight (bwt) intragastrically once, then once daily per os (PO) for 5\u2009days. Blood samples were collected at 0, 10, 20, 30 and 45\u2009min and 1, 1.5, 2, 3, 4, 6, 8, 12, 24, 36 and 48\u2009h after the single intragastric dose, once daily immediately before the PO dose, and then again at the above times after Day 5 of once daily oral dosing. Plasma pergolide concentration was quantified via ultra\u2010performance liquid chromatography\u2013tandem mass spectrometry. Pergolide concentration versus time data after the first and last doses were analysed based on noncompartmental pharmacokinetics using commercial software. Paired\n                      <jats:italic>t<\/jats:italic>\n                      \u2010tests were used to compare single and multiple doses (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u20090.05). In a follow\u2010up study, a single oral dose was then administered to two donkeys followed by concurrent blood sampling from the jugular and cephalic veins to evaluate the effect of route of administration on pergolide pharmacokinetics.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      <jats:italic>C<\/jats:italic>\n                      <jats:sub>max<\/jats:sub>\n                      ,\n                      <jats:italic>T<\/jats:italic>\n                      <jats:sub>max<\/jats:sub>\n                      AUC, and\n                      <jats:italic>t<\/jats:italic>\n                      <jats:sub>\u00bd\u03bbz<\/jats:sub>\n                      differed significantly (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0\u2264\u20090.03) after single and multiple doses, with significantly lower\n                      <jats:italic>C<\/jats:italic>\n                      <jats:sub>max<\/jats:sub>\n                      (0.16\u2009\u00b1\u20090.16\u2009ng\/ml) and\n                      <jats:italic>t<\/jats:italic>\n                      <jats:sub>\u00bd\u03bbz<\/jats:sub>\n                      (9.74\u2009\u00b1\u20091.35\u2009h) after intragastric dosing on Day 1 than after 5\u2009days of oral dosing (3.74\u2009\u00b1\u20092.26\u2009ng\/ml and 16.35\u2009\u00b1\u20095.21\u2009h, respectively). Pergolide plasma concentrations were higher in jugular vein samples compared to cephalic vein samples after a single oral dose.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main limitations<\/jats:title>\n                    <jats:p>Small sample size; varied administration routes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Pergolide mesylate (dosed at 2\u00a0\u03bcg\/kg bwt) is bioavailable in donkeys after intragastric and PO administration. Differences in pharmacokinetics were noted after multiple doses, related to different routes of administration and sublingual absorption of pergolide.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/evj.13917","type":"journal-article","created":{"date-parts":[[2022,12,26]],"date-time":"2022-12-26T23:15:58Z","timestamp":1672096558000},"page":"1078-1085","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Pharmacokinetic properties of pergolide mesylate following single and multiple\u2010dose administration in donkeys (\n                    <i>Equus asinus<\/i>\n                    )"],"prefix":"10.1111","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2756-7835","authenticated-orcid":false,"given":"Cynthia","family":"Xue","sequence":"first","affiliation":[{"name":"Department of Large Animal Medicine University of Georgia College of Veterinary Medicine  Athens Georgia 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